RESUMEN
Personal experience about a correlative study on ultrasonographic and angiographic methods executed on carotid artery is reported. Usual techniques are described and result discordances are considered. Stenosis level is subdivided in four different types: normal, less than 45, 45-75%, greater than 75%. Authors examine in which stenosis range one technique can be superimposed on the other one and show limits and possibilities. Moreover complementary and interdependence position of these two techniques are stressed with respect to atherosclerotic disease study.
Asunto(s)
Arteriosclerosis/diagnóstico , Enfermedades de las Arterias Carótidas/diagnóstico , Arteria Carótida Externa/patología , Ultrasonografía , Arteria Carótida Externa/diagnóstico por imagen , Estudios de Evaluación como Asunto , Humanos , Radiografía , Ultrasonografía/métodosRESUMEN
An examination of 80 patients with ischaemic cerebrovascular disease, subdivided into 5 groups according to platelet antiaggregant treatment, demonstrated the insufficient effectiveness of acetylsalicylic acid in preventing recurrences. The drug failure can most probably be attributed to its particular action mechanism or to dosage.
Asunto(s)
Aspirina/uso terapéutico , Trastornos Cerebrovasculares/tratamiento farmacológico , Adulto , Aspirina/administración & dosificación , Aspirina/farmacología , Trastornos Cerebrovasculares/sangre , Trastornos Cerebrovasculares/prevención & control , Ensayos Clínicos como Asunto , Femenino , Estudios de Seguimiento , Humanos , Ataque Isquémico Transitorio/sangre , Ataque Isquémico Transitorio/tratamiento farmacológico , Ataque Isquémico Transitorio/prevención & control , Masculino , Persona de Mediana Edad , Agregación Plaquetaria/efectos de los fármacos , Distribución Aleatoria , Factores de TiempoRESUMEN
A sample of 29 patients suffering from ischaemic cerebrovascular disorders was examined. Of these, 15 were treated with Ditazol (1200 mg/day in three administrations) and 14 with ASA (1 g a day in 2 administration). These patients were evaluated using serial Born and Cross tests to check ADP, Adrenaline and Collagen-induced platelet aggregation. The clinical follow-up lasted 22-34 months. As part of the laboratory evaluation, this sample was also compared with a group of 34 healthy volunteers. Ditazol was found to be an inhibitor of ADP, Adrenaline and Collagen-induced platelet aggregation: this effect constitutes clinical protection against recurrence of the complaint. Recurrence was 13.3% with Ditazol treated patients and 35.7% with ASA.
Asunto(s)
Isquemia Encefálica/tratamiento farmacológico , Oxazoles/uso terapéutico , Adenosina Difosfato/farmacología , Adulto , Anciano , Aspirina/uso terapéutico , Colágeno/farmacología , Epinefrina/farmacología , Femenino , Humanos , Ataque Isquémico Transitorio/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Agregación Plaquetaria/efectos de los fármacosRESUMEN
Personal experience in the treatment of Ischaemic Cerebrovascular Disease with platelet suppressant drugs is reported. 80 patients were treated with 5 different protocols: 1) group "A": dipyridamol (14 patients); 2) group "B": acetylsalicylic acid (ASA) (14 patients); 3) group "C": dipyridamol and ASA (22 patients); 4) group "D": ditazol (15 patients); 5) group "E": isoxsuprine resinate (15 patients) and followed-up for 22-34 months. The evolution of the disease is discussed and recurrences evaluated on the basis of initial clinical features and particular treatment given.
Asunto(s)
Isquemia Encefálica/tratamiento farmacológico , Agregación Plaquetaria/efectos de los fármacos , Adenosina Difosfato/farmacología , Aspirina/uso terapéutico , Dipiridamol/uso terapéutico , Femenino , Humanos , Isoxsuprina/uso terapéutico , Masculino , Oxazoles/uso terapéutico , RecurrenciaRESUMEN
An examination of 80 patients with ischaemic cerebrovascular disease, subdivided into 5 groups according to platelet antiaggregant treatment, demonstrated the effectiveness of resinated Isoxysuprine in preventing recurrences. The drug's success can most probably be attributed to its particular action mechanism.