RESUMEN
The aim of the study were the evaluation of generation of oxygen free radical and antioxidative enzymatic activity in blood of patients with carcinoma of larynx (7 persons, aged 48-68) in comparison with healthy persons (15, aged 21-28). The superoxide anion generation of blood granulocytes described by the rate of the reducted cytochrom C at rest and after stimulation with opsonized zymosan according to Bellavite et al. were measured. The enzymatic activity of superoxide dismutase in blood (method of Misra and Fridovich), catalase (method of Beers and Sizer) and malonyl dialdehyde (method of Placer et al.). The obtained data pointed at the growth of generation of oxygen free radical in blood (at rest and after stimulation with opsonized zymosan) of patients with carcinoma of larynx in comparison with the healthy ones. At the same patients with carcinoma of larynx observed at significant reduction of antioxidative enzymatic activity against the oxygen species generation in blood and significant growth of peroxidation lipids and disturbances of function of cells the human body.
Asunto(s)
Catalasa/sangre , Depuradores de Radicales Libres/sangre , Neoplasias Laríngeas/sangre , Malondialdehído/sangre , Superóxido Dismutasa/sangre , Adulto , Grupo Citocromo c/metabolismo , Granulocitos/metabolismo , Humanos , Especies Reactivas de Oxígeno/fisiologíaRESUMEN
Anabolic steroid use is widespread and has been associated with a variety of pathological conditions. The subject of this case is a 22 years old man with cerebral ischaemic stroke. He had no previous medical complaints but had a history of anabolic steroid abuse. This case presents a side effect of long term abuse of these drugs.
Asunto(s)
Anabolizantes/envenenamiento , Infarto Cerebral/inducido químicamente , Ataque Isquémico Transitorio/inducido químicamente , Trastornos Relacionados con Sustancias/complicaciones , Adulto , Humanos , MasculinoRESUMEN
The aim of the study was the assessment of the influence of trimetazidine (TMZ) on echocardiography parameters and oxidative stress markers in hemodialyzed patients with coronary artery disease. The studies were carried out in 9 patients group before and after 3 months of TMZ treatment in doses 3 x 20 mg. Additionally we measured MDA concentration in the blood, as a oxidative stress marker, before and after 2 and 3 months of TMZ treatment. At the start of the study impairment of relaxation as a sign of diastolic dysfunction was detected. This abnormality persisted up to the end of the study. After 3 months of TMZ treatment we observed elevation of ejection fraction from 59.17 +/- 5.99 to 65.33 +/- 8.7% (p = 0.05). Also occurred statistically significant decrease in MDA level after 2 (0.674 +/- 0.029 vs 0.627 +/- 0.034; p < 0.001) and 3 (0.674 +/- 0.029 vs 0.567 +/- 0.063 mumol/L; p = 0.001) months of TMZ treatment. Significant improvement of the left ventricular function and decrease of MDA levels in the blood might be due to intracellular mechanisms of TMZ activity. There were no side effects of the drug in hemodialyzed patients.
Asunto(s)
Enfermedad Coronaria/complicaciones , Enfermedad Coronaria/metabolismo , Ecocardiografía/efectos de los fármacos , Fallo Renal Crónico/complicaciones , Fallo Renal Crónico/terapia , Estrés Oxidativo/fisiología , Trimetazidina/farmacología , Vasodilatadores/farmacología , Enfermedad Coronaria/tratamiento farmacológico , Femenino , Radicales Libres/metabolismo , Humanos , Masculino , Persona de Mediana Edad , Diálisis Renal/métodos , Trimetazidina/uso terapéutico , Vasodilatadores/uso terapéuticoRESUMEN
The hypothesis of Mickel (1975) on multiple sclerosis suggested disturbances of lipid peroxidation in that disease. The purpose of this report was an analysis of oxygen metabolism in platelets in that disease, taking into account the peroxidation of lipids and antioxidant enzymatic protection against oxygen stress. In the reported study the concentration of malonyl dialdehyde (MDA) and the activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD-1) were determined in multiple sclerosis patients. The studied group comprised 20 non-smoking patients (9 men and 11 women) aged 21-61 years during disease exacerbation. The criteria of disease diagnosis were those suggested by Poser et al (1983). The obtained results may suggest abnormal acceleration of lipid peroxidation in platelets in this disease.