RESUMEN

Voriconazole concentrations were determined in autopsy samples of eight patients who had been treated for a median of 7 days (interquartile range [IQR], 5 days). Voriconazole penetrates well into various tissues, with median levels of 6.26 µg/g ((interquartile range [IQR], 7.87 µg/g) in the lung, 3.41 µg/g (IQR, 16.72 µg/g) in the brain, 6.89 µg/g (IQR, 24.16 µg/g) in the liver, 6.47 µg/g (IQR, 6.19 µg/g) in the kidneys, 5.60 µg/g (IQR, 11.49 µg/g) in the spleen, and 7.55 µg/g (IQR, 16.91 µg/g) in the myocardium.

Asunto(s)

Riñón/metabolismo , Hígado/metabolismo , Pulmón/metabolismo , Pirimidinas/farmacocinética , Bazo/metabolismo , Triazoles/farmacocinética , Adulto , Anciano , Aspergilosis/tratamiento farmacológico , Aspergilosis/microbiología , Autopsia , Encéfalo/metabolismo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Miocardio/metabolismo , Pirimidinas/administración & dosificación , Distribución Tisular , Triazoles/administración & dosificación , Voriconazol , Adulto Joven