Asunto(s)

Toxinas Bacterianas/química , Toxinas Bacterianas/aislamiento & purificación , Cinética , Macrólidos , Mycobacterium ulcerans/química , Resonancia Magnética Nuclear Biomolecular , Estereoisomerismo

Asunto(s)

Toxinas Bacterianas/química , Macrólidos , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Estereoisomerismo

RESUMEN

A stereoselective synthesis of (-)-tetrahydrolipstatin is described. The synthesis involves an asymmetric ester derived titanium enolate anti-aldol reaction, a nitro-aldol reaction to append the C-2' C(11) side chain, and a diastereoselective reduction of a beta-hydroxy ketone to an anti-1,3-diol functionality followed by its elaboration to (-)-tetrahydrolipstatin.

Asunto(s)

Inhibidores Enzimáticos/síntesis química , Lactonas/síntesis química , Inhibidores Enzimáticos/química , Indicadores y Reactivos , Lactonas/química , Modelos Moleculares , Conformación Molecular , Orlistat , Streptomyces