RESUMEN
Changes in the concentration of haptoglobin-glycoprotein-globulin fraction of blood serum were studied in patients with lung cancer. It was found, that haptoglobin concentration increased in accordance to a disease stage. Formation of haptoglobin hemoglobin (Hp-Hb) complex in the sera of patients may be of great importance for neutralization of superoxidative products.
Asunto(s)
Haptoglobinas/metabolismo , Neoplasias Pulmonares/sangre , Proteínas de Neoplasias/sangre , Donantes de Sangre , Estudios de Casos y Controles , Globulinas/metabolismo , Glicoproteínas/sangre , HumanosRESUMEN
117 patients with breast cancer were subjected to a comparative study for immune complexes by the polyethylene glycol precipitation method, T-lymphocytes by the E-rosette test, serum immunoglobulins by immunodiffusion as well as for lymphocyte blast transformation in response to PHA. The level and incidence of immune complexes were elevated. An increase in the tumour mass with stages is associated with high levels of circulating immune complexes. No relationship was found between morphology of the tumour and the level or incidence of immune complexes. In latest stages (III-IV) the level of immune complexes correlated significantly with depletion of T lymphocytes or their response to PHA, and also with concentration of serum IgM. The results suggest that immune complexes may function as a specific blocking factor in the course of oncological disease.
Asunto(s)
Complejo Antígeno-Anticuerpo/análisis , Neoplasias de la Mama/inmunología , Adulto , Anciano , Formación de Anticuerpos , Femenino , Humanos , Inmunidad Celular , Inmunoglobulina M/análisis , Persona de Mediana Edad , Formación de Roseta , Linfocitos T/inmunologíaRESUMEN
The level and possible pathologic relevance of circulating immune complexes (ICs) were investigated by polyethylene glycol precipitation method in sera of 109 untreated cancer patients (melanoblastoma, lung and breast cancer) and 118 patients with various immune complex diseases (collagenosis, nephropathia, vasculitis and immune hemocytopenia). The highest level of ICs was established in all patients with melanoblastoma. The raised concentration of ICs was registered in patients with malignancies of lung and breast (42 and 44%, respectively). A relationship between increased level of ICs and the rate of its growth in breast cancer patients, on the one hand, and clinical stage of the disease, on the other, was shown. The pathogenic effects of ICs in malignancies and immune complex diseases are compared.