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There was studied the state of health of females in modern sector employment: office workers (group 1) and managers (group 2), and the health of their newborns. There was established the increase of the risk for the development of extragenital disorders in groups 1 and 2 compared with the control. For adreno-genital syndrome OR = 3.83; (CI: 1.15-12.74) in group 1 and OR = 4,50 (CI: 1.24-16.28) Group 2; for respiratory diseases OR = 2.77-2.98 (CI: 1.82- 4.85) in groups 1 and 2; for digestive diseases OR = 2.45 (CI: 1.39-4.32) in group 1 and 2.77 (CI: 1.46-5.26)--in Group 2. The risk of infertility in the history of the group 2 was OR = 2.56 (CI: 1.33-4.92). The frequency of reproductive loss in the history is signficantly higher in group 1 (12,9 ? 1.28), is increasing in group 2 (20.19 ± 2.75) with 9.74 ± 2.12 in 100 females in the control. In complications of pregnancy the frequency of the threat of its interruption increases from 16.99 ± 2.31 cases per 100 females in the group 1 to 21.60 ± 2.82 in Group 2, with 11.79 ± 2.31 in the control (p < 0.01). In newborn of these female workers there was revealed an increase in the frequency of the congenital defects of development (CDD) of the circulatory system in group 1 by 1.5 times in the group 2-2.5 times if compared to the control (16.38 ± 1.41 and 24.88 ± 2.96, with 9.74 ± 2.12 cases per 100 infants (p < 0.01; p < 0.001), respectively, the frequency of congenital malformations of the urinary system in groups 1 and 2 (10.00 ± 1.14 and 10.80 ± 2.13), was significantly higher than in control--3.08 ± 1.24 per 100 births (p < 0.01); CDD of genitalia was significantly higher in group 1 (11.01 ± 1.19) with 5.13 ± 1.58 per 100 infants in the control (p < 0.01). Thus, disorders of reproductive health in females involved in modern sector employment depend on the degree of occupational hazard factors; can lead to congenital disease in their newborn, which requires the development of preventive measures.

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The article mentiones issues of preserving and strengthening the reproductive health of women workers, dealed by researchers of the laboratory, established in 1974. It describes the developed concept of the reproductive health problems and scientific research areas, developed documents, including legislative fields, formulates main prospects of the laboratory to meet the requirements of the present moment. Noted the role of the Problem Commission "Scientific basis for the reproductive health of workers", in the work of the Scientific Council on medical and environmental issues of workers' health.

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The problem of workers reproductive health protection from harmful occupational and environmental exposures is amongst the national priorities due to demographic situation in Russia and decrease of the manpower. Some issues of women's reproductive health disorders are considered from occupational health standpoint. The demographic and epidemiological data on pregnancy course and outcome, birth defects, children's morbidity etc. are presented and discussed. Some proposal as to risk management and medical surveillance of reproductive health, including legal instruments are put forward.

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The article covers problem of occupational and environmental hazards' influence on reproductive health. The authors present topics on preservation of reproductive health in international systems of chemical safety.

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The article covers analysis and summary of data on occupational traumatism among female workers engaged into various economic branches of RF. The authors analysed distribution of victims according to occupational accident types, causes of traumatism, studied dependence on the victims' age and length of service, followed the relationships with possible reproductive disorders.

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The article contains a comparative analysis of experimental data on the assessment of the general toxicological, gonadotrophic effects and morphofunctional reactions of tissue basophils under the influence of 4-bromine-o-xylene, carbon disulfide and pyracryl. Established was the gonadotrophic action of pyracryl against the growing activity of tissue basophils manifested through increased infiltration and high-level degranulation in female rats' reproductive organs. Demonstrated was that, under the influence of low-intensity chemical factors, tissue basophils morphofunctional reactions were those of organ-related nature. The quantitative assessment of tissue basophils was proposed as an informative model for studies of selective (gonadotrophic) actions of low-intensity chemical substances.

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Morphofunctional indices of pyracryl (phosphate poly-2-pyridylethylmethacrilate) effecting reproduction system of Wistar rats have been studied. It has been shown that monthly administration of pyracryl in doses 1 mg/kg and 5 mg/kg lead to infiltration of mast cells and their pronounced degranulation and impairment of blood and lymph microcirculation. As far as gonadotropic effect is concerned, its parametres depend on the administration of pyracryl. Pyracryl in doses of 1 mg/kg stimulates folliculogenesis in ovaries, a dose of 5 mg/kg may cause expressed atresia of growing follicules and changes of oestrous cycle. It is suggested that biologically active substances of mast cells in female reproduction system play an important role in realization of gonadotropic effects of pyracryl.

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