RESUMEN

OBJECTIVE: To compare redox imbalance and inflammation biomarkers in umbilical cords from pregnancies with and without preeclampsia (PE) and to analyse their relationships with perinatal outcomes. METHODS: A controlled cross-sectional study was conducted in Maceió, Alagoas, Brazil, that involved pregnant women with PE and a group of women without the disease, through the application of a standardized questionnaire. After delivery, umbilical cord samples were collected to measure antioxidant defense, products from oxidative damage, and inflammation biomarkers such as myeloperoxidase (MPO), interleukin- (IL-) 6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-α). Statistical analyses were performed using Stata version 13.0 software and IBM Statistical Package for the Social Sciences (SPSS) 20.0, adopting a 95% confidence level (α = 0.05), with the chi-square test, the Wilcoxon-Mann-Whitney test, and the multinomial and Poisson regression tests. RESULTS: One hundred PE pregnant women and 50 women without the disease were studied. The umbilical cords from PE pregnancies showed higher levels of reduced glutathione (GSH) (p ≤ 0.001), glutathione peroxidase (GPx) (p = 0.016), and malondialdehyde (MDA) (p = 0.028) and lower levels of IL-6 (p = 0.030) and TNF-α (p ≤ 0.001) than the other group, with some associations among these biomarkers with perinatal outcomes. CONCLUSION: The higher levels of GSH and GPx, in addition to the lower levels of IL-6 and TNF-α, found in the PE umbilical cord, may result from adaptive mechanisms to maintain the oxidative and inflammatory balance; however, despite these changes, the damage to the cell membranes was not minimized, as the MDA level was higher in women with PE than in women without the disease. This implies that a redox imbalance is present, confirming that other physiological and adaptive mechanisms are being activated to preserve foetal health. Therefore, the present work unveils an important role of the umbilical cord in controlling redox imbalance and inflammation in PE pregnancies. Our results reinforce the necessity for continuous research on GSH as a protective compound for the perinatal outcome, especially in PE women.

Asunto(s)

Antioxidantes/metabolismo , Biomarcadores/metabolismo , Enfermedades Fetales/diagnóstico , Inflamación/diagnóstico , Preeclampsia/fisiopatología , Nacimiento Prematuro/diagnóstico , Cordón Umbilical/patología , Adulto , Brasil/epidemiología , Estudios de Casos y Controles , Estudios Transversales , Femenino , Enfermedades Fetales/epidemiología , Enfermedades Fetales/metabolismo , Humanos , Inflamación/epidemiología , Inflamación/metabolismo , Oxidación-Reducción , Estrés Oxidativo , Embarazo , Resultado del Embarazo , Nacimiento Prematuro/epidemiología , Nacimiento Prematuro/metabolismo , Cordón Umbilical/metabolismo , Adulto Joven

RESUMEN

INTRODUCTION: Oxidative stress (OS) is the basis of several diseases. Preeclampsia (PE) is a multisystemic syndrome, considered one of the major causes of maternal and fetal mortality. The placenta is considered the main anatomical pathogenetic substrate for the disease, being the placental OS a likely critical pathway in the pathogenesis of PE. This meta-analysis aimed to verify whether there is OS in the preeclamptic placenta and which markers are altered in this condition. METHODS: The search was conducted in the following databases: MEDLINE (via PubMed), Lilacs and Scopus. Relevant studies were identified until May 2020. The quality of the studies was evaluated according to the Newcastle-Ottawa scale. RESULTS: From the 3998 screened records, 43 were finally included in the systematic review, and 23 in the meta-analysis. The biomarkers evaluated were related to cell and macromolecules' damage, such as malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OH-dG), lipid peroxides, isoprostane, total oxidant status (TOS), carbonylated proteins and some of the reactive oxygen and nitrogen species (RONS), like hydrogen peroxide and nitric oxide. It was also related to antioxidant activity, both enzymatic, including superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione S-transferase and total antioxidant status, and non-enzymatic, through quantification of reduced glutathione, vitamin C and E, zinc and copper. CONCLUSION: It was observed that there was OS in the preeclamptic placentas, based on results, like lower activity of some of the enzymes of the antioxidant system (SOD and GPx) as well as the increase in oxidative damage markers (MDA and lipid peroxide), corroborating literature data.

Asunto(s)

Estrés Oxidativo/fisiología , Placenta/metabolismo , Preeclampsia/metabolismo , Biomarcadores/metabolismo , Catalasa/metabolismo , Femenino , Glutatión Peroxidasa/metabolismo , Humanos , Embarazo , Superóxido Dismutasa/metabolismo

RESUMEN

This article aims to evaluate the associated factors with excessive weight gain in pregnant women from Maceió, the capital of Alagoas, Northeastern Brazil. Cross-sectional study with pregnant women attended in public health in the city of Maceió in 2014, of which socioeconomic, clinical (glycemia, capillary hemoglobin, and blood pressure measurement), dietary, and anthropometric data, including in the latter gestational weight gain, classified as insufficient, adequate and excessive according to the US Institute of Medicine, were collected. The combination of excessive weight gain with the independent variables was tested using the Poisson regression expressed by the Prevalence Ratio (PR) and a 95% confidence interval (CI95%). We studied 403 pregnant women with a mean age of 24.08 ± 6.01 years, with 19.9% of them displayed insufficient weight gain; 14.1% displayed adequate weight gain, and 66.0% displayed excessive weight gain, that was associated with maternal hyperglycemia (PR = 1.35; CI95% = 1.17 to 1.57; p < 0.001). Excessive weight gain is common among pregnant women evaluated with the association of this variable with maternal hyperglycemia.

Asunto(s)

Complicaciones del Embarazo , Mujeres Embarazadas , Adolescente , Adulto , Índice de Masa Corporal , Brasil/epidemiología , Estudios Transversales , Femenino , Humanos , Embarazo , Complicaciones del Embarazo/epidemiología , Aumento de Peso , Adulto Joven

RESUMEN

OBJECTIVES: To assess whether there is a risk of kidney disease during the postpartum period of women who had preeclampsia (PE). STUDY DESIGN: Observational trials were searched in the PubMed, Science Direct, Clinical trials, Cochrane, LILACS and Web of Science databases. The data extracted from the studies were systematized, and the risk of bias was evaluated for each of them. Meta-analyses were performed with studies that evaluated chronic kidney disease (CKD) and end-stage renal disease (ESRD), pooling the natural logarithms of the adjusted risk measures and the confidence intervals of each study in a random effects model. RESULTS: Of the 4149 studies evaluated, 35 articles were included in the review, of which 3 of the CKD and 6 of the ESRD presented the necessary outcomes to compose the meta-analysis. A formal registration protocol was included in the PROSPERO database (number: CRD42019111821). There was a statistically significant difference between the development of CKD (hazard ratio (HR): 1.82, confidence interval to 95% (95% CI): 1.27-2.62, P < 0.01) and ESRD (HR: 3.01, confidence interval to 95% (95% CI): 1.92-4.70, P < 0.01) in postpartum women affected by PE. CONCLUSIONS: PE was considered a risk factor for the onset of CKD and ESRD in the postpartum period. Thus, more research is needed to clarify the underlying mechanisms of this association, and to assist in determining the most appropriate and effective clinical conduct to prevent and/or treat such complications.

Asunto(s)

Fallo Renal Crónico/epidemiología , Preeclampsia/epidemiología , Adulto , Causalidad , Femenino , Humanos , Estudios Observacionales como Asunto , Periodo Posparto , Embarazo , Medición de Riesgo

RESUMEN

Abstract This article aims to evaluate the associated factors with excessive weight gain in pregnant women from Maceió, the capital of Alagoas, Northeastern Brazil. Cross-sectional study with pregnant women attended in public health in the city of Maceió in 2014, of which socioeconomic, clinical (glycemia, capillary hemoglobin, and blood pressure measurement), dietary, and anthropometric data, including in the latter gestational weight gain, classified as insufficient, adequate and excessive according to the US Institute of Medicine, were collected. The combination of excessive weight gain with the independent variables was tested using the Poisson regression expressed by the Prevalence Ratio (PR) and a 95% confidence interval (CI95%). We studied 403 pregnant women with a mean age of 24.08 ± 6.01 years, with 19.9% of them displayed insufficient weight gain; 14.1% displayed adequate weight gain, and 66.0% displayed excessive weight gain, that was associated with maternal hyperglycemia (PR = 1.35; CI95% = 1.17 to 1.57; p < 0.001). Excessive weight gain is common among pregnant women evaluated with the association of this variable with maternal hyperglycemia.

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Resumo O objetivo deste artigo é avaliar os fatores associados ao ganho ponderal excessivo em gestantes de Maceió, capital do estado de Alagoas, Nordeste do Brasil. Estudo transversal realizado com gestantes assistidas pela rede pública de saúde do município de Maceió em 2014, das quais foram coletados dados socioeconômicos, clínicos (dosagens de glicemia, hemoglobina capilar e medida de pressão arterial), dietéticos e antropométricos, incluindo neste último o ganho ponderal gestacional, classificado em insuficiente, adequado e excessivo, segundo o Instituto de Medicina dos Estados Unidos. A associação do ganho ponderal excessivo com as variáveis independentes foi testada por meio de regressão de Poisson expressa pela Razão de Prevalência (RP) e respectivos intervalos de confiança a 95% (IC95%). Foram estudadas 403 gestantes com idade média de 24,08 ± 6,01 anos, sendo que em relação ao ganho ponderal 19,9% delas o tiveram insuficiente; 14,1% adequado e 66,0% excessivo, estando este último associado à hiperglicemia materna (RP = 1,35; IC95% = 1,17-1,57; p < 0,001). O ganho ponderal excessivo foi frequente entre as gestantes avaliadas, com associação dessa variável com a hiperglicemia materna.

Asunto(s)

Humanos , Femenino , Embarazo , Adolescente , Adulto , Adulto Joven , Complicaciones del Embarazo/epidemiología , Mujeres Embarazadas , Brasil/epidemiología , Aumento de Peso , Índice de Masa Corporal , Estudios Transversales

RESUMEN

OBJECTIVE: To compare redox and inflammatory markers between normal and PE-derived placentas and to evaluate the relationship between placental redox imbalance markers and perinatal outcomes in pregnancies with PE. METHODS: This was a cross-sectional study conducted at the maternity hospital of a university hospital in Maceio-Alagoas, Brazil, in 2017, including women diagnosed with PE and healthy pregnant women and their conceptuses. After screening, standardized questionnaires containing socioeconomic, clinical, obstetric and anthropometric data were applied. After delivery, placental samples were collected for quantification of biomarkers of redox imbalance (catalase - CAT; malondialdehyde - MDA; hydrogen peroxide - H2O2; superoxide dismutase - SOD; reduced glutathione - GSH; oxidized glutathione - GSSG; and their ratio - GSH/GSSG) and inflammation (myeloperoxidase - MPO; interleukin (IL)-6; IL-8; IL-10; and tumor necrosis factor-alpha - TNF-α). All biomarkers were evaluated via linear regression with adjustments of variables with measures of weight, length, head circumference (HC), chest circumference (CC) and gestational age of newborns at birth, considering p < 0.05 as significant. RESULTS: A total of 100 pregnant women with PE and 50 healthy pregnant women were studied. Higher placental levels of catalase (p = 0.018), SOD (p = 0.031), the GSH/GSSG ratio (p = 0.019) and IL-6 (p = 0.010) and lower GSSG (p = 0.001) were observed in pregnant women with PE than in the control group. Positive associations between placental GSH levels and body weight, HC, CC and gestational age at birth (p < 0.05) were identified. CONCLUSION: PE-derived placentas had high concentrations of some antioxidants (enzymes and thiols), which might be a compensation mechanism against oxidative stress. Placental GSH levels were the only biomarker, among the studied ones, related positively with beneficial perinatal outcomes, suggesting that this endogenous antioxidant plays an important role in maintaining the health of the conceptus and women with PE.

Asunto(s)

Biomarcadores/metabolismo , Estrés Oxidativo/fisiología , Placenta/metabolismo , Preeclampsia/metabolismo , Resultado del Embarazo , Adulto , Biomarcadores/análisis , Estudios Transversales , Femenino , Humanos , Recién Nacido , Masculino , Embarazo , Adulto Joven

RESUMEN

The occurrence of hypertensive syndromes during pregnancy leads to high rates of maternal-fetal morbidity and mortality. Amongst them, preeclampsia (PE) is one of the most common. This review aims to describe the relationship between oxidative stress and inflammation in PE, aiming to reinforce its importance in the context of the disease and to discuss perspectives on clinical and nutritional treatment, in this line of research. Despite the still incomplete understanding of the pathophysiology of PE, it is well accepted that there are placental changes in pregnancy, associated with an imbalance between the production of reactive oxygen species and the antioxidant defence system, characterizing the placental oxidative stress that leads to an increase in the production of proinflammatory cytokines. Hence, a generalized inflammatory process occurs, besides the presence of progressive vascular endothelial damage, leading to the dysfunction of the placenta. There is no consensus in the literature on the best strategies for prevention and treatment of the disease, especially for the control of oxidative stress and inflammation. In view of the above, it is evident the important connection between oxidative stress and inflammatory process in the pathogenesis of PE, being that this disease is capable of causing serious implications on both maternal and fetal health. Reports on the use of anti-inflammatory and antioxidant compounds are analysed and still considered controversial. As such, the field is open for new basic and clinical research, aiming the development of innovative therapeutic approaches to prevent and to treat PE.

Asunto(s)

Citocinas/metabolismo , Estrés Oxidativo , Placenta/metabolismo , Preeclampsia/metabolismo , Proteínas Gestacionales/metabolismo , Especies Reactivas de Oxígeno/metabolismo , Animales , Femenino , Humanos , Inflamación/metabolismo , Inflamación/patología , Inflamación/terapia , Placenta/patología , Preeclampsia/patología , Preeclampsia/terapia , Embarazo

RESUMEN

Abstract Objectives: to compare the adverse perinatal outcomes in pregnancies of adolescents and elderly women of public health network. Methods: a cross-sectional study carried out with pregnant women at the extremes of reproductive age according to the classification of the Brazilian Ministry of Health (adolescents those aged ≤19 years and those who were older than 35 years) and their newborns. Socioeconomic data (income, schooling, occupation and marital status), as well as clinical (diseases), anthropometric (maternal BMI) and perinatal (gender, weight, length, Apgar and gestational age) data were collected, and Poisson regression in hierarchical model was performed, with the results in Ratio of Prevalence (PR) and its respective Confidence Interval at 95% (95% CI). Results: when comparing adolescent and elderly women, 38.7% vs 54.6% (PR=0.71, CI=0.54-0.94, p=0.002) were observed, respectively, cesarean deliveries; 37.8% vs 25.2% (PR=0.83, CI=0.58-1.19, p=0.332) preterm births; 16.6% vs 20.5% (RP=1.07, CI=0.78-1.46, p=0.666) births of small infants for gestational age (SGA); 18.0% vs 15.3% (RP=1.01, CI=0.69-1.47, p=0.948) births of large-for-gestational-age newborns (LGA); 32.2% vs 34.7% (RP=1.08, CI=0.82-1.42, p=0.578), low birth weight infants and 28.5% vs 42.9% (RP=1.18, CI=0.91-1.54, p=0.201) with high birth length. Conclusions: When compared with adolescent women, pregnant women of advanced age presented a higher frequency of cesarean deliveries.

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Resumo Objetivos: comparar os resultados perinatais adversos em gestações de adolescentes e mulheres em idade avançada de rede pública de saúde. Métodos: estudo transversal realizado com gestantes nos extremos de idade reprodutiva segundo classificação do Ministério da Saúde do Brasil (adolescentes aquelas com idade ≤19 anos e em idade avançada aquelas com idade ≥35 anos) e seus recém-nascidos. Foram coletados dados socioeconômicos (renda, escolaridade, ocupação e situação conjugal), clínicos (presença de doenças), antropométricos (IMC materno) e perinatais (sexo, peso, comprimento, Apgar e idade gestacional), e realizada regressão de Poisson em modelo hie-rarquizado, com resultados em Razão de Prevalência (RP) e respectivo Intervalo de Confiança a 95% (IC95%). Resultados: quando comparadas gestantes adolescentes e aquelas em idade avançada, foram observados, respectivamente: 38,7% vs 54,6% (RP=0,71; IC=0,54-0,94; p=0,002) partos cesarianos; 37,8% vs 25,2% (RP=0,83; IC=0,58-1,19; p=0,332) nascimentos de pré-termos; 16,6% vs 20,5% (RP=1,07; IC=0,78-1,46; p=0,666) nascimentos de recém-nascidos pequenos para idade gestacional; 18,0% vs 15,3% (RP=1,01; IC=0,69-1,47; p=0,948) nascimentos de recém-nascidos grandes para a idade gestacional; 32,2% vs 34,7% (RP=1,08; IC=0,82-1,42; p=0,578)recém-nascidos com baixo peso ao nascer e28,5% vs 42,9% (RP=1,18; IC=0,91-1,54; p=0,201) com comprimento elevado ao nascer. Conclusões: as gestantes em idade avançada quando comparadas com as adolescentes apresentaram maior frequência de partos cesarianos.

Asunto(s)

Humanos , Femenino , Embarazo , Recién Nacido , Adolescente , Adulto , Complicaciones del Embarazo , Embarazo en Adolescencia , Edad Materna , Puntaje de Apgar , Factores Socioeconómicos , Brasil , Cesárea , Antropometría , Estudios Transversales , Edad Gestacional , Embarazo de Alto Riesgo , Sistemas Públicos de Salud

RESUMEN

The present article aimed to evaluate the consumption of protective foods and predictors of cardiovascular (CV) risk and its relationship with cardiovascular risk factors (CVRF) by hypertensive individuals in the state of Alagoas. A population-based cross-sectional study was carried out from 2013 to 2016 with 655 hypertensive adults of both sexes. Food consumption was assessed by a validated food frequency questionnaire with measurements converted to scores and the foods were divided into three groups: I - processed foods/CV risk predictors; II - ultraprocessed foods/higher CV risk predictors; III - in natura or minimally processed foods/ CV risk protectors. Socioeconomic, demographic, biochemical, clinical and anthropometric variables were also analyzed. The consumption scores of food groups I, II and III were, respectively, 0.11; 0.13 and 0.24 (p = 0.001). The consumption of processed foods was correlated positively with high blood cholesterol (p = 0.045) and negatively with age (p = 0.001); while that of ultraprocessed foods was correlated with the sedentary lifestyle (p = 0.01). Thus, it was observed a relationship between the consumption of CV risk predictors foods with high blood cholesterol and sedentary lifestyle, reflecting the need for nutricional education actions.

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O presente artigo teve como objetivo avaliar o consumo de alimentos protetores e preditores de risco cardiovascular (CV) e sua relação com fatores de risco cardiovascular (FRCV) por hipertensos do estado de Alagoas. Estudo transversal, de base populacional, com 655 adultos, hipertensos, de ambos os sexos, estudados no período de 2013 a 2016. O consumo alimentar foi avaliado por um questionário de frequência alimentar validado com mensuração convertida em escores e os alimentos foram divididos em três grupos: I - processados/preditores de risco CV; II - ultraprocessados/maiores preditores de risco CV; III - alimentos in natura ou minimamente processados/protetores de risco CV. Foram também analisadas variáveis socioeconômicas, demográficas, bioquímicas, clínicas e antropométricas. Os escores de consumo dos grupos de alimentos I, II e III foram, respectivamente, 0,11; 0,13 e 0,24 (p = 0,001). O consumo de alimentos processados se correlacionou positivamente com o colesterol sérico elevado (p = 0,045) e negativamente com a idade (p = 0,001); já o de alimentos ultraprocessados correlacionou-se com o sedentarismo (p = 0,01). Assim, observou-se relação entre o consumo de alimentos preditores de risco CV com sedentarismo e colesterol elevado, refletindo a necessidade de ações de educação nutricional.

Asunto(s)

Enfermedades Cardiovasculares/epidemiología , Ingestión de Alimentos , Comida Rápida/estadística & datos numéricos , Hipertensión/epidemiología , Adulto , Factores de Edad , Brasil/epidemiología , Enfermedades Cardiovasculares/etiología , Colesterol/sangre , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Conducta Sedentaria , Encuestas y Cuestionarios , Adulto Joven

RESUMEN

Resumo O presente artigo teve como objetivo avaliar o consumo de alimentos protetores e preditores de risco cardiovascular (CV) e sua relação com fatores de risco cardiovascular (FRCV) por hipertensos do estado de Alagoas. Estudo transversal, de base populacional, com 655 adultos, hipertensos, de ambos os sexos, estudados no período de 2013 a 2016. O consumo alimentar foi avaliado por um questionário de frequência alimentar validado com mensuração convertida em escores e os alimentos foram divididos em três grupos: I - processados/preditores de risco CV; II - ultraprocessados/maiores preditores de risco CV; III - alimentos in natura ou minimamente processados/protetores de risco CV. Foram também analisadas variáveis socioeconômicas, demográficas, bioquímicas, clínicas e antropométricas. Os escores de consumo dos grupos de alimentos I, II e III foram, respectivamente, 0,11; 0,13 e 0,24 (p = 0,001). O consumo de alimentos processados se correlacionou positivamente com o colesterol sérico elevado (p = 0,045) e negativamente com a idade (p = 0,001); já o de alimentos ultraprocessados correlacionou-se com o sedentarismo (p = 0,01). Assim, observou-se relação entre o consumo de alimentos preditores de risco CV com sedentarismo e colesterol elevado, refletindo a necessidade de ações de educação nutricional.

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Abstract The present article aimed to evaluate the consumption of protective foods and predictors of cardiovascular (CV) risk and its relationship with cardiovascular risk factors (CVRF) by hypertensive individuals in the state of Alagoas. A population-based cross-sectional study was carried out from 2013 to 2016 with 655 hypertensive adults of both sexes. Food consumption was assessed by a validated food frequency questionnaire with measurements converted to scores and the foods were divided into three groups: I - processed foods/CV risk predictors; II - ultraprocessed foods/higher CV risk predictors; III - in natura or minimally processed foods/ CV risk protectors. Socioeconomic, demographic, biochemical, clinical and anthropometric variables were also analyzed. The consumption scores of food groups I, II and III were, respectively, 0.11; 0.13 and 0.24 (p = 0.001). The consumption of processed foods was correlated positively with high blood cholesterol (p = 0.045) and negatively with age (p = 0.001); while that of ultraprocessed foods was correlated with the sedentary lifestyle (p = 0.01). Thus, it was observed a relationship between the consumption of CV risk predictors foods with high blood cholesterol and sedentary lifestyle, reflecting the need for nutricional education actions.

Asunto(s)

Humanos , Masculino , Femenino , Adulto , Adulto Joven , Enfermedades Cardiovasculares/epidemiología , Ingestión de Alimentos , Comida Rápida/estadística & datos numéricos , Hipertensión/epidemiología , Brasil/epidemiología , Enfermedades Cardiovasculares/etiología , Colesterol/sangre , Estudios Transversales , Encuestas y Cuestionarios , Factores de Riesgo , Factores de Edad , Conducta Sedentaria , Persona de Mediana Edad

RESUMEN

This article describes a systematic review of the literature on studies that have used the scores method proposed by Fornés et al. (2002) to evaluate food consumption and discuss the method from the perspective of food pattern assessment. The search of the Medline, Lilacs and Scielo databases was limited to the English, Portuguese and Spanish languages and to articles published from 2002 to 2016. The inclusion criterion was studies that used the scores method proposed by Fornés et al. to evaluate food consumption. The original search found 8300 items. After reading titles and abstracts and applying the exclusion criteria, 14 articles were selected. The articles evaluating food pattern used different groupings and examined associations with anthropometric, socioeconomic and biochemical variables. It was concluded that the scores method is able to evaluate food patterns and enables associations to be established between anthropometric, biochemical, socioeconomic and clinical variables and the components of the study diet/food grouping to which the individual was exposed.

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O presente artigo tem como objetivo revisar de forma sistematizada a literatura relativa a estudos que utilizaram o método dos escores proposto por Fornés e colaboradores, em 2002, para avaliar o consumo alimentar e discutir o método na perspectiva de avaliação do padrão alimentar. Foi realizada busca de artigos nas bases de dados Medline, Lilacs e Scielo. Limitou-se a busca aos idiomas inglês, português e espanhol e aos artigos publicados de 2002 até 2016. Os critérios de inclusão foram: estudos que utilizaram o método dos escores proposto por Fornés et al. para avaliar o consumo alimentar. Foram encontrados 8.300 artigos na busca inicial. Após leitura de títulos, resumos e aplicação de critérios de exclusão, 14 artigos foram selecionados. Os artigos avaliaram o padrão alimentar adotando diferentes grupos e verificaram associações com variáveis antropométricas, socioeconômicas e bioquímicas. Concluiu-se que o método dos escores constitui uma ferramenta capaz de avaliar os padrões alimentares e que permite verificar associações entre variáveis antropométricas, bioquímicas, socioeconômicas e clínica com os componentes da dieta/grupo alimentar investigado aos quais o indivíduo foi exposto.

Asunto(s)

Dieta , Conducta Alimentaria , Brasil , Humanos , Factores Socioeconómicos

RESUMEN

Resumo O presente artigo tem como objetivo revisar de forma sistematizada a literatura relativa a estudos que utilizaram o método dos escores proposto por Fornés e colaboradores, em 2002, para avaliar o consumo alimentar e discutir o método na perspectiva de avaliação do padrão alimentar. Foi realizada busca de artigos nas bases de dados Medline, Lilacs e Scielo. Limitou-se a busca aos idiomas inglês, português e espanhol e aos artigos publicados de 2002 até 2016. Os critérios de inclusão foram: estudos que utilizaram o método dos escores proposto por Fornés et al. para avaliar o consumo alimentar. Foram encontrados 8.300 artigos na busca inicial. Após leitura de títulos, resumos e aplicação de critérios de exclusão, 14 artigos foram selecionados. Os artigos avaliaram o padrão alimentar adotando diferentes grupos e verificaram associações com variáveis antropométricas, socioeconômicas e bioquímicas. Concluiu-se que o método dos escores constitui uma ferramenta capaz de avaliar os padrões alimentares e que permite verificar associações entre variáveis antropométricas, bioquímicas, socioeconômicas e clínica com os componentes da dieta/grupo alimentar investigado aos quais o indivíduo foi exposto.

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Abstract This article describes a systematic review of the literature on studies that have used the scores method proposed by Fornés et al. (2002) to evaluate food consumption and discuss the method from the perspective of food pattern assessment. The search of the Medline, Lilacs and Scielo databases was limited to the English, Portuguese and Spanish languages and to articles published from 2002 to 2016. The inclusion criterion was studies that used the scores method proposed by Fornés et al. to evaluate food consumption. The original search found 8300 items. After reading titles and abstracts and applying the exclusion criteria, 14 articles were selected. The articles evaluating food pattern used different groupings and examined associations with anthropometric, socioeconomic and biochemical variables. It was concluded that the scores method is able to evaluate food patterns and enables associations to be established between anthropometric, biochemical, socioeconomic and clinical variables and the components of the study diet/food grouping to which the individual was exposed.

Asunto(s)

Humanos , Dieta , Conducta Alimentaria , Factores Socioeconómicos , Brasil

RESUMEN

Abstract Objectives: to analyze the factors associated with the birth of small for gestational age (SGA)infants, in a Northeastern Brazilian capital. Methods: a cross-sectional study was carried out with 331 pregnant women and their newborns attending the public health network in the city of Maceió, in 2014. Maternal antenatal data were collected (socioeconomic, lifestyle, clinical and nutritional) as well as data of the newborns (gestational age, mode of delivery, sex, birth weight and length), after delivery. Birth weight was classified according to the INTERGROWTH-21st curves, being considered SGA those below the 10th percentile according to gestational age and gender. The results were analyzed by Poisson regression using a hierarchical model and were expressed as prevalence ratios (PR) and their respective 95% confidence intervals (CI95%). Results: it was verified that 5.1% of the newborns were SGA. Regarding the associated factors, after adjustment of the hierarchical model, the variable working outside the home was associated with the endpoint studied [PR = 0.14; (CI95% = 0.02-0.75); p=0.022]. Conclusions: it was verified a low frequency of SGA infants in the evaluated population. The fact that the mother works outside the home proved to be a protective factor for this condition.

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Resumo Objetivos: analisar os fatores associados ao nascimento de recém-nascidos pequenos para a idade gestacional (PIG), em uma capital do Nordeste brasileiro. Métodos: estudo transversal realizado com 331 gestantes e seus recém-nascidos atendidos na rede pública de saúde do município de Maceió, em 2014. Foi realizada a coleta de dados maternos antes do parto (socioeconômicos, de estilo de vida, clínicos e nutricionais) e após o parto os dados dos recém-nascidos (idade gestacional no momento do parto, via de parto, sexo, peso e comprimento ao nascer). O peso ao nascer foi classificado segundo as curvas do INTERGROWTH-21st, sendo considerados PIG aqueles abaixo do percentil 10 de acordo com a idade gestacional e o sexo. Os resultados foram analisados por regressão de Poisson, com emprego de modelo hierarquizado, sendo expressos como razões de prevalência [RP] e seus respectivos intervalos de confiança de 95% (IC95%). Resultados: foi constatado que 5,1% dos recém-nascidos eram PIG. Quanto aos fatores associados, após ajuste do modelo hierarquizado, permaneceu-se associada ao desfecho estudado a variável trabalhar fora do lar [RP=0,14; (IC95%=0,02-0,75); p=0,022]. Conclusões: foi verificada baixa frequência de recém-nascidos PIG na população avaliada. O fato da mãe trabalhar fora do lar mostrou-se como fator protetor para esta condição.

Asunto(s)

Humanos , Femenino , Embarazo , Recién Nacido , Peso al Nacer , Recién Nacido Pequeño para la Edad Gestacional , Factores de Riesgo , Atención Prenatal , Sistema Único de Salud , Brasil , Distribución de Poisson , Edad Gestacional , Mujeres Embarazadas , Periodo Posparto , Factores Protectores

RESUMEN

ABSTRACT Objective To evaluate the intake of antioxidant nutrients by pregnant women being cared for in the Brazilian public health system and associated factors. Methods A cross-sectional study was carried out with pregnant women cared for in the public health system in the city of Maceió, Brazil, in 2014, including 385 pregnant women and their newborns, and the collection of maternal information (socioeconomic, personal, prenatal, dietary and anthropometric data), and after the babies' birth (gestational age, birth weight and length). Food intake was assessed by two 24-hour dietary reminders per pregnant woman with subsequent adjustments by the Estimated Average Requirement method. Data were processed and Pearson's correlation was used to evaluate associations, considering p<0.05 as significant. Results A total of 388 pregnant women with a mean age of 24.06±5.92 years were studied, with inadequate intake and high variation of the following antioxidants: vitamin A (83.2%/62.7%), vitamin C (50.5%/75.7%), vitamin E (76.5%/60.2%), Selenium (60.8%/50.3%), Copper (98.5%/42.8%) and Zinc (79.6%/43.4%), respectively. Additionally, the following associations were observed: the intake of vitamin A (p=0.02), Copper (p=0.01), and Selenium (p=0.01) with the maternal Body Mass Index; the intake of vitamin A (0.04) and Selenium (p=0.02) with the birth weight; and between vitamin A (p=0.04) with the birth length. Conclusion The low intake of antioxidant nutrients by pregnant women is a reality, being associated to the maternal Body Mass Index and the birth weight and length of the newborn.

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RESUMO Objetivo O objetivo deste estudo foi avaliar a ingestão de nutrientes antioxidantes por gestantes atendidas em rede pública de saúde e os fatores associados. Métodos Trata-se de estudo transversal com gestantes atendidas na rede pública de saúde do município de Maceió no ano de 2014, sendo incluídas 385 gestantes e seus recém-nascidos. Foram coletadas informações acerca das mães (dados socioeconômicos, pessoais, de pré-natal, dietéticos e antropométricos) e, após o parto, dos recém-nascidos (idade gestacional, peso e comprimento ao nascer). A ingestão alimentar foi avaliada por dois recordatórios alimentares de 24h, relatados pela gestante, com posteriores ajustes pelo método Estimativa de Requerimento Médio. Os dados foram processados, sendo utilizada a correlação de Pearson para avaliar associações, com p<0,05 como significativo. Resultados Foram estudadas 388 gestantes, com média de idade de 24,06±5,92 anos, com ingestão inadequada e alta variação da ingestão dos antioxidantes: Vitamina A (83,2%/62,7%), Vitamina C (50,5%/75,7%), Vitamina E (76,5%/60,2%), Selênio (60,8%/ 50,3%), Cobre (98,5%/42,8%) e Zinco (79,6%/43,4%), respectivamente. Adicionalmente, foi observada associação entre a ingestão de vitamina A (p=0,02), Cobre (p=0,01) e Selênio (p=0,01), e o Índice de Massa Corporal materno. Observou-se também associação entre a ingestão de vitamina A (0,04) e selênio (p=0,02) e o peso ao nascer; e de vitamina A (p=0,04) com comprimento ao nascer. Conclusão A baixa ingestão de nutrientes antioxidantes por gestantes é uma realidade, estando associada ao Índice de Massa Corporal materno e ao peso e comprimento do recém-nascido ao nascer.

Asunto(s)

Humanos , Femenino , Embarazo , Mujeres Embarazadas , Embarazo , Nutrientes , Estudios Transversales , Ingestión de Alimentos , Antioxidantes

RESUMEN

The clinical and nutritional status of pregnant women are important variables for birth-weight risk inadequacies. Thus, this study sought to evaluate the nutritional status of high-risk pregnant women and its association with birth weight of their offspring. It involved a cross-sectional study with high-risk pregnant women assisted at the university hospital of Maceio in the State of Alagoas and their newborns. The nutritional status of pregnant women and their offspring was evaluated according to body mass index for gestational age and birth weight, respectively. The association between maternal factors (comorbidities and nutritional status) and birth weight was assessed by the chi-square test and Pearson correlation, by adopting a confidence level of 95%. One hundred and forty-nine pregnant women were studied, 19.7% of whom were of normal weight; 32% were underweight; and 48.3% were overweight. Among newborns, 39.6% referred to as small for gestational age (SGA); 26.8% appropriate for gestational age (AGA) and 33.6% large for gestational age (LGA). LGA offspring were associated with overweight and the presence of metabolic comorbidities and SGA offspring were associated with insufficient gestational weight gain, whereby interventions are needed to reduce these outcomes.

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O estado clínico e o nutricional da gestante representam importantes variáveis para o risco de inadequações de peso ao nascer. Assim, o presente estudo visou avaliar o estado nutricional de gestantes de alto risco e sua associação com o peso ao nascer de seus conceptos. Estudo transversal com gestantes de alto risco assistidas no Hospital Universitário de Maceió-AL e seus recém-nascidos. O estado nutricional das gestantes e de seus conceptos foi avaliado segundo o Índice de Massa Corporal para a idade gestacional e o peso ao nascer, respectivamente. A associação entre fatores maternos (comorbidades e estado nutricional) e o peso ao nascer foram realizadas pelos testes de qui-quadrado e correlação de Pearson, adotando um nível de confiança de 95% (α = 0,05). Foram estudadas 149 gestantes, com 19,7% delas com baixo peso; 32,0% eutróficas e 48,3% com excesso de peso. Entre os recém-nascidos, 39,6% eram pequenos para idade gestacional (PIG); 26,8% adequados para a idade gestacional (AIG) e 33,6% grandes para a idade gestacional (GIG). O excesso de peso gestacional e a presença de comorbidades metabólicas se associaram com o nascimento de recém-nascidos GIG e o ganho ponderal gestacional insuficiente com o nascimento de recém-nascidos PIG, sendo fundamentais intervenções para redução desses desfechos.

Asunto(s)

Peso al Nacer , Estado Nutricional , Complicaciones del Embarazo/epidemiología , Fenómenos Fisiologicos de la Nutrición Prenatal/fisiología , Adolescente , Adulto , Índice de Masa Corporal , Brasil , Estudios Transversales , Femenino , Edad Gestacional , Hospitales Universitarios , Humanos , Recién Nacido , Recién Nacido Pequeño para la Edad Gestacional , Masculino , Embarazo , Embarazo de Alto Riesgo , Factores de Riesgo , Aumento de Peso/fisiología , Adulto Joven

RESUMEN

Resumo O estado clínico e o nutricional da gestante representam importantes variáveis para o risco de inadequações de peso ao nascer. Assim, o presente estudo visou avaliar o estado nutricional de gestantes de alto risco e sua associação com o peso ao nascer de seus conceptos. Estudo transversal com gestantes de alto risco assistidas no Hospital Universitário de Maceió-AL e seus recém-nascidos. O estado nutricional das gestantes e de seus conceptos foi avaliado segundo o Índice de Massa Corporal para a idade gestacional e o peso ao nascer, respectivamente. A associação entre fatores maternos (comorbidades e estado nutricional) e o peso ao nascer foram realizadas pelos testes de qui-quadrado e correlação de Pearson, adotando um nível de confiança de 95% (α = 0,05). Foram estudadas 149 gestantes, com 19,7% delas com baixo peso; 32,0% eutróficas e 48,3% com excesso de peso. Entre os recém-nascidos, 39,6% eram pequenos para idade gestacional (PIG); 26,8% adequados para a idade gestacional (AIG) e 33,6% grandes para a idade gestacional (GIG). O excesso de peso gestacional e a presença de comorbidades metabólicas se associaram com o nascimento de recém-nascidos GIG e o ganho ponderal gestacional insuficiente com o nascimento de recém-nascidos PIG, sendo fundamentais intervenções para redução desses desfechos.

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Abstract The clinical and nutritional status of pregnant women are important variables for birth-weight risk inadequacies. Thus, this study sought to evaluate the nutritional status of high-risk pregnant women and its association with birth weight of their offspring. It involved a cross-sectional study with high-risk pregnant women assisted at the university hospital of Maceio in the State of Alagoas and their newborns. The nutritional status of pregnant women and their offspring was evaluated according to body mass index for gestational age and birth weight, respectively. The association between maternal factors (comorbidities and nutritional status) and birth weight was assessed by the chi-square test and Pearson correlation, by adopting a confidence level of 95%. One hundred and forty-nine pregnant women were studied, 19.7% of whom were of normal weight; 32% were underweight; and 48.3% were overweight. Among newborns, 39.6% referred to as small for gestational age (SGA); 26.8% appropriate for gestational age (AGA) and 33.6% large for gestational age (LGA). LGA offspring were associated with overweight and the presence of metabolic comorbidities and SGA offspring were associated with insufficient gestational weight gain, whereby interventions are needed to reduce these outcomes.

Asunto(s)

Humanos , Masculino , Femenino , Embarazo , Recién Nacido , Adolescente , Adulto , Adulto Joven , Complicaciones del Embarazo/epidemiología , Peso al Nacer , Estado Nutricional , Fenómenos Fisiologicos de la Nutrición Prenatal/fisiología , Brasil , Recién Nacido Pequeño para la Edad Gestacional , Aumento de Peso/fisiología , Índice de Masa Corporal , Estudios Transversales , Factores de Riesgo , Edad Gestacional , Embarazo de Alto Riesgo , Hospitales Universitarios

RESUMEN

Restricted sodium intake has been recommended for more than 1 century for the treatment of hypertension. However, restriction seems to increase blood cholesterol. In women with excess weight, blood cholesterol may increase even more because of insulin resistance and the high lipolytic activity of adipose tissue.The aim of this study was to assess the association between blood cholesterol and sodium intake in hypertensive women with and without excess weight.This was a cross-sectional study with hypertensive and nondiabetic women aged 20 to 59 years, recruited at the primary healthcare units of Maceio, Alagoas, Brazilian Northeast. Excess weight was defined as body mass index (BMI) ≥25.0 kg/m. Sodium intake was estimated by the 24-hour urinary excretion of sodium. Blood cholesterol was the primary outcome investigated by this study, and its relationship with sodium intake and other variables was assessed by Pearson correlation and multivariate linear regression using a significance level of 5%.This study included 165 hypertensive women. Of these, 135 (81.8%) were with excess weight. The mean sodium intake was 3.7 g (±1.9) and 3.4 g (±2.4) in hypertensive women with and without excess weight, respectively. The multiple normal linear regression models fitted to the "blood cholesterol" in the 2 groups reveal that for the group of hypertensive women without excess weight only 1 independent variable "age" is statistically significant to explain the variability of the blood cholesterol levels. However, for the group of hypertensive women with excess weight, 2 independent variables, age and sodium intake, can statistically explain variations of the blood cholesterol levels.Blood cholesterol is statistically inversely related to sodium intake for hypertensive women with excess weight, but it is not statistically related to sodium intake for hypertensive women without excess weight.

Asunto(s)

Colesterol/sangre , Hipertensión , Sobrepeso , Sodio en la Dieta/metabolismo , Sodio/orina , Adulto , Índice de Masa Corporal , Brasil/epidemiología , Estudios Transversales , Dieta Hiposódica/métodos , Femenino , Humanos , Hipertensión/dietoterapia , Hipertensión/metabolismo , Hipertensión/fisiopatología , Persona de Mediana Edad , Sobrepeso/diagnóstico , Sobrepeso/metabolismo , Sobrepeso/fisiopatología , Estadística como Asunto

RESUMEN

Introdução: Apesar das estratégias e da implementação de guias e políticas para o combate à anemia carencial terem sido adotadas há bastante tempo, a sua prevalência no país vem se mantendo elevada, especialmente em grupos especiais, sendo esta carência considerada um problema de saúde pública. Assim, o objetivo desse estudo foi avaliar a prevalência e os fatores associados à não utilização de suplemento antianêmico por gestantes de alto risco de Alagoas. Método: Estudo transversal, realizado com gestantes assistidas no hospital universitário de Maceió, sendo estudadas variáveis socioeconômicas, de estilo de vida, antropométricas, e investigado o uso de suplementação ferrosa, com utilização da regressão de Poisson, e resultados expressos em razão de prevalência (RP) e intervalos de confiança (IC) de 95%. Resultados: Foram estudadas 210 gestantes na faixa etária de 13 a 43 anos de idade. O não uso de suplemento ferroso foi referido por 37,6% das mesmas, estando associado (gestantes que não utilizavam suplementação profilática versus gestantes que utilizavam suplementação profilática) ao baixo peso na gravidez, sendo, essa variável fator de proteção para esta condição (RP=0,47; IC de 95%= 0,24 a 0,93; p=0,030). Conclusão: A não utilização da suplementação antianêmica por parte de gestantes de alto risco de Alagoas é um problema de magnitude elevada, tornando evidente a necessidade de aumentar a cobertura da suplementação antianêmica entre elas.

Asunto(s)

Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Fenómenos Fisiológicos Nutricionales del Lactante , Hierro , Estado Nutricional , Embarazo de Alto Riesgo

RESUMEN

Modelo do estudo: Estudo transversal, de base populacional, descritivo. Objetivo do estudo: Descrever o perfil clínico-epidemiológico dos portadores de hipertensão arterial sistêmica atendidos na atenção básica do estado de Alagoas. Metodologia: Estudo realizado nas Unidades Básicas de Saúde de 12 municípios de Alagoas, entre 2014 e 2015, com indivíduos entre 20 e 60 anos, de ambos os sexos, portadores de hipertensão arterial sistêmica. Foram coletados dados socioeconômicos, demográficos, clínicos, de estilo de vida, antropométricos e bioquímicos. Os dados foram analisados segundo estatística descritiva, no Epi-Info versão 7. Resultados: Foram avaliados 645 indivíduos. Destes, 86,2% eram mulheres, 62,3% estavam com a pressão arterial não controlada, 72,8% tinham baixa escolaridade, 11,1% eram fumantes, 26,3% consumiam bebida alcoólica, 64,7% eram sedentários, 48,4% eram obesos, 73,6% apresentavam risco cardiovascular muito elevado, segundo a circunferência da cintura; 54,4% e 47,2% apesentavam colesterol total e triglicerídeos elevados, respectivamente. Conclusão: Visto que a hipertensão arterial sistêmica é um importante problema de saúde pública e que apresenta consequências graves, o conhecimento do perfil da população hipertensa de Alagoas facilitará o tratamento integral à saúde dos portadores dessa condição. (AU)

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Study design: This was a cross-sectional, population-based and descriptive study. Study objective: To describe the clinical and epidemiological profile of hypertensive patients at the primary health care of Alagoas state. Methods: This study was carried out in the Basic Health Units of 12 cities of Alagoas, between 2014 and 2015, with hypertensive individuals between 20 and 60 years, of both gender. Socioeconomic, demographic, clinical, lifestyle, anthropometric and biochemical data were collected. Data were analyzed using descriptive statistics by Epi-Info version 7. Results: We evaluated 645 individuals. Of these, 86.2% were women, 62.3% had uncontrolled blood pressure, 41.9% had low educational level, 11.1% were smokers, 26.3% were alcohol users, 64.7% were sedentary, 48.4% were obese, 73.6% had high cardiovascular risk, according to waist circumference; 54.4% and 47.2% had elevated total cholesterol and triglycerides, respectively. Conclusion: Since hypertension is an important public health problem that has serious consequences, the knowledge of the hypertensive population profile of Alagoas will facilitate the treatment for the health of patients with this condition. (AU)

Asunto(s)

Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Antropometría , Epidemiología , Hipertensión , Obesidad , Atención Primaria de Salud , Factores de Riesgo

RESUMEN

Introdução: Na gestação, as demandas energéticas estão aumentadas visando à promoção de um adequado desenvolvimento. Tal grupo populacional, quando acometido pela insegurança alimentar (IA), tem comprometimento na qualidade da alimentação, pois há influência no consumo de alimentos. Método: Estudo transversal com gestantes atendidas pela rede pública de saúde de Maceió, AL, em 2014. O padrão de consumo dietético foi avaliado por meio de recordatórios alimentares de 24 horas e de questionário de frequência de consumo alimentar, e a presença da IA no domicílio pela Escala Brasileira de IA, com utilização dos testes do χ2 e o teste T de Student, considerando p<0,05 como significativo. Resultados: Foram estudadas 356 gestantes, sendo 42,7% com IA. A maioria tinha elevado consumo diário de arroz (95,5%), feijão (82,0%) e pães (72,7%). Por outro lado, leite e derivados (53,3%), ovos (26,5%) e as carnes (59,0%) foram alimentos de baixo consumo, sendo o último ainda menor nas gestantes com IA (p=0,025). Adicionalmente, esse padrão de consumo refletiu em uma alimentação com baixo aporte energético, dos micronutrientes ácido fólico, ferro, selênio, zinco e cálcio, e de fibras. Conclusão: O padrão de consumo alimentar das gestantes estudadas é caracterizado pelo baixo consumo energético e de nutrientes essenciais ao bom êxito da gravidez. A presença da IA no domicílio não levou a maior comprometimento desse padrão dietético, exceção ao consumo de carnes.(AU)

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Introduction: During the pregnancy the energy demands are increased aimed at promoting a proper development. This population group when affected by food insecurity (FI) has compromised the quality of food, it influences on food consumption. Methods: Cross-sectional study of pregnant women by the public health Maceió, AL, in 2014. The pattern of dietary intake was assessed by food 24-hour recalls and a questionnaire of food intake frequency, and the presence of FI in home by the Brazilian Scale FI, using the χ2 and Student's t test, considering p<0.05 as significant. Results: We studied 356 pregnant women, being 42.7% FI. Most had high daily consumption of rice (95.5%), beans (82.0%) and bread (72.7%). On the other hand, dairy products (53.3%), eggs (26.5%) and meat (59.0%) were low-energy food, the latter being even lower in pregnant women with FI (p=0.025). In addition, this consumption pattern reflected in a power low energy intake, micronutrients folic acid, iron, selenium, zinc and calcium and fiber. Conclusion: The dietary patterns of pregnant women studied is characterized by low energy and nutrients essential to the successful pregnancy. The presence of FI in the household has not led to greater commitment of this dietary pattern, except to meat consumption, which it was lower in the presence of FI.(AU)

Asunto(s)

Humanos , Femenino , Embarazo , Atención Prenatal , Ingestión de Alimentos , Mujeres Embarazadas/psicología , Dieta , Encuestas sobre Dietas/instrumentación , Estudios Transversales/instrumentación