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Objective: To assess botulinum toxin-A (BTX-A) on mandibular movements and bite force (BF%) in bruxism.Methods: Ten bruxers were divided into 2 groups based on BF% imbalance (G1: >10%, G2: <10%). BTX-A 140U was total injected into the masseter and temporalis muscles. A T-Scan® recorded BF%, occlusion time (OT), right, left, and protrusive disclusion time (DT) before administering BTX-A, as well as 15, 45, 90, and 120 days after injection.Results: The Friedman and Wilcoxon tests found significant differences in BF% in G1 subjects at 15 days (p = 0.028 s), OT at 90 (p = 0.043 s), and 120 (p = 0.027 s) days, DTR at 90 (p = 0.046 s) and 120 (p = 0.028 s) days, DTL at 15 (p = 0.043 s) and 90 (p = 0.027 s) days, and DTP 45-90 days (p = 0.043 s).Conclusion: BTX-A induced BF% starting at 15 days post-injection and influenced lateralities later.
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Toxinas Botulínicas Tipo A , Bruxismo , Fármacos Neuromusculares , Toxinas Botulínicas Tipo A/uso terapéutico , Bruxismo/tratamiento farmacológico , Humanos , Músculo Masetero , Fármacos Neuromusculares/uso terapéutico , Proyectos PilotoRESUMEN
BACKGROUND: This paper aimed to compare the tooth color changes and sensitivity in patients undergoing dental bleaching with 10% hydrogen peroxide using customized trays or strips as delivering systems. METHODS: A total of 50 patients aged between 18-30 years old were assigned into two groups (N.=25) according to the bleaching treatment: tray (TB) or strips (SB). For both techniques, the patients underwent a 30-minute application of 10% hydrogen peroxide twice a day for seven days. Tooth color was evaluated before, 3 and 7 days of treatment, and 14 days after bleaching using a tooth color shade guide (VITA® shade). Tooth sensitivity was assessed using the Visual Analogue Scale (VAS). The values obtained from the color changes and tooth sensitivity were statistically analyzed (α=5%). RESULTS: For both groups, there was a significant difference on the tooth color before and after bleaching (P<0.001), although there was no significant difference between them (P=0.4215). The SB group exhibited a lower frequency of sensitivity (50.2%) compared to the TB group (70.2%) (P<0.001). However, the highest number of individuals reporting score 1 of sensitivity was found in the SB group (37.3%) compared to the TB group (20.9%) (P<0.001). For the other scores, there were no differences between the SB and TB groups, with results of 9.8% and 8.4% for score 2 (P=0.744) and 2.7% and 0.5% for score 3 (P=0.122). CONCLUSIONS: The bleaching effect of 10% hydrogen peroxide is not influenced by the delivering system (tray or strips). Even though the technique with strips was associated to a lower frequency of dental sensitivity, the peak level of pain was greater when compared to the technique using trays.
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Esmalte Dental/efectos de los fármacos , Peróxido de Hidrógeno/farmacología , Blanqueadores Dentales/farmacología , Blanqueamiento de Dientes/instrumentación , Decoloración de Dientes/terapia , Odontalgia/etiología , Adolescente , Adulto , Color , Colorimetría , Femenino , Humanos , Peróxido de Hidrógeno/administración & dosificación , Masculino , Presión , Blanqueamiento de Dientes/efectos adversos , Blanqueamiento de Dientes/métodos , Blanqueadores Dentales/administración & dosificación , Blanqueadores Dentales/efectos adversos , Escala Visual Analógica , Adulto JovenRESUMEN
Laser phototherapy emerges as an alternative or auxiliary therapy for acute ischemic stroke, traumatic brain injury, degenerative brain disease, spinal cord injury, and peripheral nerve regeneration, but its effects are still controversial. We have previously found that laser phototherapy immunomodulates the response to focal brain damage. Following direct cortical cryogenic injury the effects of laser phototherapy on inflammation and repair was assessed after cryogenic injury (CI) to the central nervous system (CNS) of rats. The laser phototherapy was carried out with a 780 nm AlGaAs diode laser. The irradiation parameters were: power of 40 mW, beam area of 0.04 cm(2), energy density of 3 J/cm(2) (3s) in two points (0.12 J per point). Two irradiations were performed at 3 h-intervals, in contact mode. Rats (20 non-irradiated - controls and 20 irradiated) were used. The wound healing in the CNS was followed in 6 h, 1, 7 and 14 days after the last irradiation. The size of the lesions, the neuron cell viability percentages and the amount of positive GFAP labeling were statistically compared by ANOVA complemented by Tukey's test (p<0.05). The distribution of lymphocytes, leukocytes and macrophages were also analyzed. CI created focal lesions in the cortex represented by necrosis, edema, hemorrhage and inflammatory infiltrate. The most striking findings were: lased lesions showed smaller tissue loss than control lesions in 6 h. During the first 24 h the amount of viable neurons was significantly higher in the lased group. There was a remarkable increase in the amount of GFAP in the control group by 14 days. Moreover, the lesions of irradiated animals had fewer leukocytes and lymphocytes in the first 24 h than controls. Considering the experimental conditions of this study it was concluded that laser phototherapy exerts its effect in wound healing following CI by controlling the brain damage, preventing neuron death and severe astrogliosis that could indicate the possibility of a better clinical outcome.
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Isquemia Encefálica/fisiopatología , Isquemia Encefálica/radioterapia , Frío/efectos adversos , Terapia por Luz de Baja Intensidad , Cicatrización de Heridas/efectos de la radiación , Animales , Isquemia Encefálica/etiología , Isquemia Encefálica/patología , Supervivencia Celular/efectos de la radiación , Leucocitos/inmunología , Leucocitos/efectos de la radiación , Masculino , Neuroglía/patología , Neuroglía/efectos de la radiación , Neuronas/patología , Neuronas/efectos de la radiación , Ratas , Ratas WistarRESUMEN
Surgeries performed with high-intensity laser devices may be improved with accurate protocols, including the air-water spray regulation. Thus, this study sought to investigate the healing process of wounds made on the dorsum of rat tongues using an Er,Cr:YSGG laser device with different air-water spray regulations. The incisions were made on the dorsum of Wistar rat tongues using an Er,Cr:YSGG laser with three different air-water spray regulations (100/0%, 50/50%, 11/7%). Scalpel incisions functioned as controls. The sacrifices occurred between 0 and 14 days after surgery. Morphological, histological, and immunohistochemical (fibronectin and type III collagen) analysis of the wounds were performed. The air-water spray regulation influenced wound healing and the inflammatory response, especially in the earlier stages. Incisions performed using the 100/0% air/water spray regulation had the worst results, expressing a greater amount of fibronectin and type III collagen. The 50/50% air/water spray regulation brought in a non-clear surgical field and poor laser interaction with the tissue. The 11/7% air/water spray regulation showed the best clinical results and less pronounced histological events. According to the results encountered, the air-water spray should be regulated to improve surgery.
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Terapia por Láser/instrumentación , Lengua/lesiones , Cicatrización de Heridas , Aire , Animales , Femenino , Láseres de Estado Sólido , Modelos Animales , Ratas , Ratas Wistar , AguaRESUMEN
PURPOSE: The aim of this in vitro study was to evaluate the microtensile bond strength (microTBS) and hybrid layer morphology of different adhesive systems, either followed by treatment with Nd:YAG laser irradiation or not. Previous studies have shown the effects of Nd:YAG laser irradiation on the dentin surface at restoration margins, but there are few reports about the significance of the irradiation on the hybrid layer. MATERIALS AND METHODS: The flattened coronal and root dentin samples of 24 bovine teeth were randomly divided into 8 groups, according to the adhesive system used -- Scotchbond Multi Purpose (SBMP) or Clearfil SE Bond (CSEB) -- and were either irradiated with Nd:YAG or not, with different parameters: 0.8 W/10 Hz, 0.8 W/20 Hz, 1.2 W/10 Hz, 1.2 W/20 Hz. The left sides of specimens were the control groups, and right sides were irradiated. A composite crown was built over bonded surfaces and stored in water (24 h at 37 degrees C). Specimens were sectioned vertically into slabs that were subjected to microTBS testing and observed by SEM. RESULTS: Control groups (27.81 +/- 1.38) showed statistically higher values than lased groups (21.37 +/- 0.99), and CSEB control group values (31.26 +/- 15.71) were statistically higher than those of SBMP (24.3 +/- 10.66). There were no significant differences between CSEB (20.34 +/- 10.01) and SBMP (22.43 +/- 9.82) lased groups. Among parameters tested, 0.8 W/10 Hz showed the highest value (25.54 +/- 11.74). Nd:YAG laser irradiation caused dentin to melt under the adhesive layer of both adhesive systems tested. CONCLUSION: With the parameters used in this study, Nd:YAG laser irradiation of the hybrid layer promoted morphological changes in dentin and negatively influenced the bond strength of both adhesive systems.