RESUMEN

Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. In this review article, we critically analyzed the contribution of these scaffolds to medicinal chemistry in the last five years, focusing on tropical infectious diseases, such as Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria. We also present perspectives for their use in drug design in order to contribute to the development of new drugs.

Asunto(s)

Infecciones por Protozoos/tratamiento farmacológico , Semicarbazonas/uso terapéutico , Tiazoles/uso terapéutico , Tiosemicarbazonas/uso terapéutico , Animales , Enfermedad de Chagas/tratamiento farmacológico , Diseño de Fármacos , Humanos , Leishmaniasis/tratamiento farmacológico , Malaria/tratamiento farmacológico , Tripanosomiasis Africana/tratamiento farmacológico