Asunto(s)
Combinación Amoxicilina-Clavulanato de Potasio/uso terapéutico , Antibacterianos/uso terapéutico , Edema/patología , Dolor de la Región Lumbar/tratamiento farmacológico , Dolor de la Región Lumbar/patología , Corticoesteroides/uso terapéutico , Antiinflamatorios no Esteroideos/uso terapéutico , Enfermedad Crónica , Estudios de Cohortes , Terapia Combinada , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Quimioterapia Combinada , Edema/diagnóstico , Edema/tratamiento farmacológico , Terapia por Ejercicio/métodos , Estudios de Seguimiento , Imidazoles , Inyecciones Espinales , Dolor de la Región Lumbar/diagnóstico por imagen , Dolor de la Región Lumbar/rehabilitación , Imagen por Resonancia Magnética/métodos , Placa Motora/diagnóstico por imagen , Placa Motora/fisiopatología , Estudios Prospectivos , Medición de Riesgo , Índice de Severidad de la Enfermedad , Insuficiencia del TratamientoRESUMEN
While rapidly destructive OA is more recognized in hip, we report the case of a 50-year-old woman who presented a rapid chondrolysis in the patellofemoral joint in a context of rapid loss of muscular strength. She had arthralgia, myalgia and proximal muscular deficit of the limbs. Creatine phospho kinase level was elevated and electromyogram exam showed a myogenic syndrome. Neither immune nor visceral disease was highlighted. As we suspected a polymyositis, we started corticosteroids and physiotherapy, then methotrexate and intravenous immunoglobulin. Concomitantly to the worsening of the muscular deficit and atrophy of hamstrings, she developed a persistent and disabling knee pain. Initial radiographs and magnetic resonance imaging (MRI) showed only a patellofemoral dysplasia and tiny cartilage damages. Because of aggravation of myalgia, we treated by mycophenolate mofetyl then rituximab. One year later, the knee remained painful and swollen. MRI showed signs of advanced osteoarthritis including an important loss of cartilage with an atrophy of hamstrings. Several articular corticosteroids injections were done. In the same time, the evolution of the muscular disease was unusual. Another histological analysis of muscle has highlighted a genetic myopathy due to mutation of calpain. Immunosuppressive treatments were stopped and a total joint replacement was performed. We show for the first time a case of rapid chondrolysis of patellofemoral joint related to a severe genetic myopathy.