RESUMEN
2 cases of acute dermatitis caused by butterfly Hylesia metabus in an area that so far has not been considered as endemic for this species were presented. The dermatitis observed in these individuals may be described as very circumscribed, pruriginous, erythematous generalized protruding papules that may be compared with urticaria, and with a variable degree oedema. Monomorphic eruption consisting in small hard papules crowned by a little vesicle was also present. The lesions of these 2 patients evolved with intensely pruriginous papules for a week and after that they healed without dermatological sequelae.
Asunto(s)
Dermatitis por Contacto/etiología , Lepidópteros/patogenicidad , Adulto , Animales , Terapia Combinada , Dermatitis por Contacto/patología , Dermatitis por Contacto/terapia , Humanos , Masculino , Prurigo/etiología , Prurigo/patología , Prurigo/terapia , Piel/patología , Factores de Tiempo , VenezuelaRESUMEN
American cutaneous leishmaniasis is characterized by a spectrum of clinical manifestations. These include localized, often self-healing single lesions, intermediate forms which frequently produce mucosal lesions and often show exaggerated delayed-type hypersensitivity (DTH), and the rare diffuse cutaneous leishmaniasis in which no reaction of protective cell-mediated immunity or DTH can be demonstrated. Clinical, pathological and immunological studies have begun to unravel some of the mechanisms associated with different disease manifestations, dependent on complex interactions between the host immune response, measured in terms of indices including lymphocyte subsets and lymphokines in vitro and within active lesions, and different species of Leishmania.
Asunto(s)
Leishmaniasis Cutánea/inmunología , Piel/inmunología , Animales , Antígenos de Protozoos/inmunología , Ensayo de Inmunoadsorción Enzimática , Femenino , Humanos , Hipersensibilidad Tardía/inmunología , Leishmania mexicana/inmunología , Leishmaniasis Cutánea/patología , Leishmaniasis Cutánea Difusa/inmunología , Leishmaniasis Mucocutánea/inmunología , Activación de Linfocitos/inmunología , Masculino , Piel/patologíaRESUMEN
The purpose of this study was to evaluate serum levels of TNF-alpha in patients with either of the three clinical forms of American cutaneous leishmaniasis. The 86 patients examined were classified as having either the localized (LCL: 22 patients), mucocutaneous (MCL: 45 patients), or the rare diffuse (DCL: 19 patients) form of the disease. Our results show a significant increase in the mean level of TNF-alpha in the three groups of patients when compared to controls. MCL patients produce significantly higher levels of TNF-alpha than DCL patients. The proportion of individuals positive for serum TNF-alpha was significantly higher in both MCL and DCL patients than in the controls. No significant differences were found in the level of TNF-alpha when compared between before and after cure of 12 patients with MCL. There were no significant correlations between the level of TNF-alpha and the skin test diameter. The results will be discussed in terms of the pathogenesis of the disease in its different clinical forms.