RESUMEN
Pemphigus vulgaris (PV) is a potentially fatal autoimmune blistering disease of the skin and mucous membranes, characterized by flaccid bullae that rupture and leave erosions. Its treatment is challenging. Although the use of systemic corticosteroids remains the cornerstone of effective therapeutic regimens for PV, their prolonged administration may lead to serious side effects. It is therefore necessary, for many patients, to add immunosuppressive agents or use immunomodulatory procedures to achieve remission. This paper will summarize the treatments available for PV, while focusing on the most recently available therapeutic options.
Asunto(s)
Pénfigo/terapia , Corticoesteroides/uso terapéutico , Antiinflamatorios/uso terapéutico , Quimioterapia Combinada , Humanos , Inmunosupresores/uso terapéutico , Inmunoterapia/métodosAsunto(s)
Erupciones por Medicamentos/etiología , Ibuprofeno/efectos adversos , Interleucina-2/efectos adversos , Penfigoide Ampolloso/inducido químicamente , Penicilinas/efectos adversos , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Adulto , Anciano , Niño , Preescolar , Diagnóstico Diferencial , Erupciones por Medicamentos/complicaciones , Erupciones por Medicamentos/diagnóstico , Erupciones por Medicamentos/terapia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Penfigoide Ampolloso/complicaciones , Penfigoide Ampolloso/diagnóstico , Penfigoide Ampolloso/terapia , Traumatismos por Radiación/etiología , Radioterapia/efectos adversosAsunto(s)
Úlcera de la Pierna/inducido químicamente , Corticoesteroides/efectos adversos , Hipersensibilidad a las Drogas/complicaciones , Humanos , Úlcera de la Pierna/patología , Úlcera de la Pierna/terapia , Levamisol/efectos adversos , Pentamidina/efectos adversos , Abuso de Sustancias por Vía Intravenosa/complicacionesAsunto(s)
Hipersensibilidad a las Drogas/etiología , Penicilinas/efectos adversos , Adolescente , Adulto , Anafilaxia/inducido químicamente , Anemia Hemolítica/inducido químicamente , Niño , Desensibilización Inmunológica , Erupciones por Medicamentos/etiología , Hipersensibilidad a las Drogas/terapia , Femenino , Humanos , Persona de Mediana Edad , Pénfigo/inducido químicamente , Embarazo , Enfermedades Cutáneas Vesiculoampollosas/inducido químicamente , Urticaria/inducido químicamenteRESUMEN
A retrospective study of patients with pemphigus vulgaris, drug eruptions, psoriasis, and normal controls was undertaken in an attempt to determine whether a significant difference in drug exposure and/or drug allergy existed between the various groups. A statistically significant difference in drug exposure was found between pemphigus vulgaris and drug eruption patients, as compared with psoriatics and normal patients. Representative case reports and some possible mechanisms for the induction or exacerbation of pemphigus patients is described and discussed.
Asunto(s)
Hipersensibilidad a las Drogas/complicaciones , Pénfigo/etiología , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Penicilinas/efectos adversos , Psoriasis/tratamiento farmacológico , Estudios Retrospectivos , Cuero Cabelludo/patología , Piel/inmunologíaRESUMEN
Keratoacanthomas have been associated with multiple carcinomas, discoid lupus erythematosus, and multiple sebaceous gland tumors with colonic and gastric carcinoma. Steatocystoma multiplex has been associated with ichthyosis and koilonychia, pachyonychia congenita, multiple hairs and acrokeratosis verruciformis of Hopf, hypertrophic lichen planus, hypohidrosis, hypothyroidism, hidradenitis suppurativa, and hypotrichosis. We report a case of multiple keratoacanthoma associated with steatocystoma multiplex and rheumatoid arthritis.
Asunto(s)
Artritis Reumatoide/complicaciones , Quiste Epidérmico/complicaciones , Queratoacantoma/complicaciones , Enfermedades de la Piel/complicaciones , Quiste Epidérmico/genética , Quiste Epidérmico/patología , Humanos , Queratoacantoma/patología , Masculino , Persona de Mediana Edad , Piel/patología , Enfermedades de la Piel/patologíaRESUMEN
A 39-year-old man developed allergic hypersensitivity to lidocaine hydrochloride and showed urticarial dermographism. Although hypersensitivity reactions to local anesthetics are rare and are usually due to esters of procaine, reaction to the amides of lidocaine can occur. A review of the literature for the past decade revealed only four reported cases of allergic hypersensitivity to lidocaine hydrochloride.
Asunto(s)
Hipersensibilidad a las Drogas/etiología , Lidocaína/inmunología , Adolescente , Adulto , Anestesia Dental/efectos adversos , Niño , Femenino , Humanos , Lidocaína/efectos adversos , Masculino , Persona de Mediana Edad , Pruebas Cutáneas , Urticaria/inducido químicamenteAsunto(s)
Liquen Plano/diagnóstico , Complemento C3/inmunología , Técnica del Anticuerpo Fluorescente , Humanos , Inmunoglobulina G/inmunología , Liquen Plano/tratamiento farmacológico , Liquen Plano/etiología , Enfermedades de la Uña/etiología , Piel/patología , Esteroides/uso terapéutico , Linfocitos T/inmunologíaRESUMEN
The skin of 41 patients including 16 blacks, 15 Caucasians, and 10 Hispanics, was observed using a fluorescent microscope. Three patterns of autofluorescence were observed: intercellular, cytoplasmic, and a combination of intercellular and cytoplasmic. The hair of 75 subjects, including 18 Negroes and 55 Caucasians, was observed. Two patterns were found: medullar and at the cortex. Skin form black patients was associated with the cytoplasmic pattern of autofluorescence. Compared to lighter skin, black skin was also significantly associated with increased intensity of autofluorescence, indicating that autofluorescence of the epidermis parallels the clinical degree of pigmentation. In the hair of 75 subjects, similar results were obtained: Negro hair exhibited more fluorescence than Caucasian hair, and darker hair (brown to black) exhibited more fluorescence than lighter hair (blond). This may be related to melanin and it breakdown products.