RESUMEN

We have evaluated eight p-coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 ((E)-3,4-diprenyl-4-isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC50=45.92 µM) and S. mansoni (IC50=64.25 µM). Data indicated that the number of prenyl groups, the presence of hydroxyl at C9, and a single bond between C7 and C8 are important structural features for the antileishmanial activity of p-coumaric acid prenylated derivatives.

Asunto(s)

Antiprotozoarios , Ácidos Cumáricos , Leishmania , Pruebas de Sensibilidad Parasitaria , Schistosoma mansoni , Animales , Schistosoma mansoni/efectos de los fármacos , Ácidos Cumáricos/farmacología , Ácidos Cumáricos/química , Leishmania/efectos de los fármacos , Antiprotozoarios/farmacología , Antiprotozoarios/química , Antiprotozoarios/síntesis química , Relación Estructura-Actividad , Prenilación , Propionatos/farmacología , Propionatos/química , Estructura Molecular , Esquistosomicidas/farmacología , Esquistosomicidas/química , Esquistosomicidas/síntesis química , Relación Dosis-Respuesta a Droga