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OBJECTIVE: To identify possible associations between premorbid personality traits and cognitive impairment and affective symptoms in patients who have recovered from COVID-19. MATERIAL AND METHODS: The study included 30 people with the so-called post-COVID syndrome. The diagnosis of COVID-19 was previously confirmed by laboratory tests in each patient. The control group included 15 healthy individuals. The Hospital Anxiety and Depression Scale was used to assess depression and anxiety. Cognitive function was assessed using the Verbal Fluency Test (VF), the Montreal Cognitive Scale (MOCA), and the Wisconsin Card Sorting Test (WCST). The Munich Personality Test (MRT) and the Toronto Alexithymia Scale (TAS-26) were used to assess premorbid personality characteristics. Multiple stepwise regression analysis was used as the main statistical method to identify the relationship between premorbid personality constructs and cognitive test results and affective and anxiety symptoms. RESULTS: The presence of frustration tolerance in the personality structure reduced the number of incorrect answers (beta coefficient -0.811) in WCST and decreased the delay in responses with positive reinforcement (-0.630), and also reduced the level of depression (-0.465). Extraversion decreased the MOCA test score (-0.675) and increased the percentage of perseverative incorrect answers on the WCST test (0.573). The constructs of adherence to social norms and propensity to isolate lowered the final MOCA score (beta coefficients are -0.725 and -0.527, respectively). The esoteric tendencies construct decreased the latency of positive and negative reinforcement responses in WCST (-0.441 and -0.528, respectively). The severity of alexithymia was positively correlated with depression (beta 0.577), while neuroticism was positively correlated with anxiety (0.737). CONCLUSION: Low levels of frustration tolerance and esoteric tendencies have negative effects on cognition in COVID-19 survivors, while high levels of these constructs are protective against cognitive decline and depression.

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OBJECTIVE: The current study has been performed in order to find the influence of premorbid personality traits on psychopathological symptomatology in patients with endogenous depression (ED), schizophrenia and organic anxiety-depressive disorder (OADD). MATERIAL AND METHODS: 191 patients (57 with OADD,93 with schizophrenia and 41 with ED) were included into study. The Munich personality test (MPT) and Toronto alexithymia scale (TAS) were used for the evaluation of premorbid personality; the SCL-90 - for the assessment of psychopathological structure. The multiple regression analysis has been used for the assessment of relationships between premorbid personality constructs and psychopathological status separately in each diagnostic group. RESULTS: The SCL-90 scores were maximal in ED and schizophrenia patients and minimal in OADD patients (p<0.047). Comparison of premorbid personality constructs revealed the maximal values of neuroticism and motivation in ED (p=0.005), rigidity, extraversion and esoteric tendencies in schizophrenia (p<0.007) and frustration tolerance, tendency to isolation and alexithymia in OADD (p<0.02). Regression analysis revealed the positive dependence of anxiety and depression on alexithymia score (TAS-26) (p<0.002) and negative dependence on frustration tolerance in ED and schizophrenia patients (p<0.016). The negative dependence of anxiety Zung scale score on frustration tolerance in OADD patients also has been observed (p=0.003). The rigidity construct has not stochastically significant relationships neither with anxiety, nor with depression in none diagnostic group. CONCLUSION: The analysis revealed the predominance of certain personality constructs in each of the diseases, with a universal negative effect of alexithymia and a positive effect of frustration tolerance in anxiety-depressive disorders of any etiology.

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OBJECTIVE: To compare premorbid personality and structure of psychopathological status of organic anxiety-depressive disorder in comparison with endogenous depression and anxiety neurotic disorders. MATERIAL AND METHODS: One hundred and twelve patients, including 57 with organic anxiety-depressive disorder (OADD), 41 with endogenous depression (ED) and 14 with anxiety neurotic disorder (AND) were studied. have been included into the study. The Munich personality test (MPT) and Toronto alexithymia scale (TAS) were used for the evaluation of premorbid personality. Psychopathological structure was assessed with SCL-90. The correlation between premorbid personality and current structure of psychopathological states was studied. RESULTS: OADD patients were characterized by higher scores of frustration tolerance, rigidity and isolation tendency and less expression of neuroticism, esoteric tendencies and motivation compared with ED. In the AND patients, the values of neuroticism and motivation predominated compared with OADD, while the value of frustration tolerance was higher in OADD. A correlation analysis revealed the strong positive relationships of alexithymia, neuroticism and isolation tendency with depression, anxiety, somatization, obsessions and sensitivity in AND group. CONCLUSION: The comparison of correlations between OADD and ED revealed no significant differences. It implies the similarity in the pathogenesis of OADD and ED.

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This work is concentrated on synthesis and investigation of new core-shell nanocomposites of polystyrene (PS) with doped polyaniline (PANI). The latex containing PS nanoparticles with sizes of 15-30 nm was prepared by microemulsion polymerization of styrene in water media. The PS/PANI nanocomposites were synthesized by chemical oxidative polymerization of aniline in the PS latex media in a presence of lauryl sulfuric acid (LSA), which served as both dopant and plasticizer. The real content of PANI in the synthesized nanocomposites was determined by UV-Vis spectroscopy method. The composition of the nanocomposites and oxidation state of the doped polyaniline were characterized by FTIR spectroscopy. The core-shell morphology of the nanocomposite nanoparticles was proved by transmission and scanning electron microscopy. It was found that conductivity and thermal behavior in air of these nanocomposites not only nonlinearly depended on the doped polyaniline content but also were strongly effected both by plasticizing properties of the acid-dopant and presence of the polyaniline shell. A possibility of application of these nanocomposites as sensor materials has been demonstrated.

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Presented herein are the results of successful surgical treatment by extraanatomic bypass grafting of coarctation of the aorta complicated by septic aortitis and a pseudoaneurysm of the anastomosis between the graft and aortic arch.

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As many as 208 patients with carcinoma of the stomach were examined, with 98 of these, having been victims of Chernobyl accident. It has been established that in spite of the fact that the clinical picture was practically identical in both case groups those patients having been exposed to mixed radiation demonstrated more clearly manifest endogenous intoxication, impairement of erythrocytic membrane function, which fact calls correction of these changes in the preoperative period.

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The results of ultra-violet irradiation of the blood in 207 patients after performance of thoracoabdominal operation for cancer of the esophagus and stomach were analysed. The method permits to reduce the incidence of postoperative complications, manifestations of endogenous intoxication, contributes to improvement in metabolic processes, and normalization of the state of the patients.

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With the aim of diagnosis of postoperative pancreatitis in 88 oncologic patients operated on for malignant tumors of the upper alimentary canal and pancreatoduodenal zone, including those with trauma or resection of the pancreas, the comparative analysis of significance of different biochemical indices was carried out. A high sensitivity and informative value of measuring a content of the middle molecular mass peptides and components of kallikrein-kinin system with calculation of a toxicity coefficient permit to recommend their use as the additional diagnostic criteria.

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