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Magnetic nanoparticle-based hyperthermia as a new cancer treatment technology has been applied for some kinds of tumors. To review the different applications and effectiveness of this new cancer treatment technique, PubMed, Science Direct, Web of Science, and Google Scholar databases were explored up to November 2022, using the following keywords combined in different ways: "Magnetic Nanoparticles Based Hyperthermia", "Magnetic Nanoparticles" AND "Hyperthermia" AND "Cancer". The obtained results were screened for the title and abstract and the relevant papers were reviewed for further details. Finally, 24 papers were included in the study. These papers have evaluated the application of magnetic nanoparticle-based hyperthermia for treating different cancers including breast, liver, prostate, pancreas, colon, brain, lung, and stem cell. Various nanoparticles including Iron Oxide (Fe2O3, Fe3O4), Dextran Spermine, Iron Chloride, Magnetic nanoparticles conjugated with Liposomes (MCLs), and Variable Molecular Weight Nanoparticles (VMWNPs) were used in different reviewed studies. The results of reviewed studies revealed that the nanoparticle-based hyperthermia technique as a new progressive modality can significantly improve treatment outcomes for some special cancers. Increasing life expectancy by up to 30% using Iron Oxide magnetic nanoparticle-based hyperthermia for pancreatic cancer and increasing tumor ablation by about 33% for other cancers were reported in reviewed articles. However, further studies are required to extend this new treatment technique to other cancers and for providing more accurate information on nanoparticle-based hyperthermia's effectiveness as a complementary technique in cancer treatment.
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Hipertermia Inducida , Nanopartículas de Magnetita , Neoplasias , Masculino , Humanos , Adulto , Nanopartículas de Magnetita/uso terapéutico , Hipertermia Inducida/métodos , Neoplasias/terapia , PulmónRESUMEN
OBJECTIVE: Although epidemiological studies have failed to show the harmful effects of ultrasound in humans, as a form of energy, ultrasound has the potential to cause bio-effects in tissues. Therefore, clinical guidelines have been established for ultrasound technology related to human safety, which include Thermal (TI) and mechanical (MI) indices. The appropriate TI and MI ranges for embryonic examinations are between 0-1.0 and 0-0.4, respectively. The accepted TI and MI ranges are 0-2.0 and 0-1.9, respectively, for general ultrasound examinations. In addition, the scan duration should be kept as low as possible. Therefore, the present study aimed at evaluating the scan duration, TI, and MI as measures of acoustic output during ultrasound studies. METHODS: A cross-sectional descriptive study was conducted for patients undergoing pregnancy checkups, routine checkups, and initial diagnosis ultrasound examinations. Samples were selected from imaging departments of 4 educational hospitals based on convenience sampling and 321 checklists completed by direct observation of ultrasound examinations. RESULTS: For pregnancy scans, the mean TI and MI were obtained as 0.32 ± 0.27 and 1.15 ± 0.13, respectively. For non-pregnancy examinations, the mean value of TI and MI were 0.30 ± 0.29 and 1.07 ± 0.35, respectively. Therefore, mean TI for pregnancy and non-pregnancy examinations and mean MI for non-pregnancy studies obtained lower than the permitted values, while the mean MI was higher than the permitted level for first trimester of pregnancy. Also, relatively suitable scan durations were seen in reviewed studies. CONCLUSION: From this study, it may be concluded that the reported ultrasound scans were safe.
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Ultrasonografía Prenatal , Estudios Transversales , Femenino , Humanos , Embarazo , Primer Trimestre del Embarazo , Estudios Prospectivos , UltrasonografíaRESUMEN
INTRODUCTION: Producing appropriate diagnostic images along with patient radiation protection is the goal of radiography. Due to the advancements of radiography, concerns about observing the principles of radiation protection exist. Therefore, this study aimed to evaluate the observance of the principles of radiation protection in radiographic examinations with emphasis on field size collimation, suitability of exposure factors and the use of protective equipment for the patients and their companions. METHODS: Using a cross-sectional study design, two radiography students on their final year of study observed 100 radiographic examinations from the imaging departments of five educational hospitals. The SPSS version 24 software was used to analyse the results. RESULTS: The radiation field collimation was obtained in 46% of the studied radiographs. Patients had companions present during the examination in 26% of the studies; however, protective equipment was only used for 4% of the patients' companions, and no protective equipment was applied for patients. The observance rate of the various principles of radiation protection including field size restriction, the use of protective equipment for the patients and their companions, and suitability of the selected exposure factors was on average 44.6%. CONCLUSION: The observance rate of the principles of radiation protection was insufficient in the studied educational hospitals, specifically in field size collimation and the use of protective equipment for the patients and their companions. Therefore, emphasis on the strict implementation of the radiation protection guidelines and continuous training of radiographers are required.
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Exposición a la Radiación/efectos adversos , Protección Radiológica/instrumentación , Humanos , Radiología , Medición de RiesgoRESUMEN
BACKGROUND: Considering the non-invasive nature of magnetic resonance spectroscopy (MRS) and its ability to detect prostate lesions, the present study aimed to investigate the accuracy of MRS techniques in distinguishing between prostate cancer (PCa) and prostatitis. METHODS: Thirty-three patients (18 patients with PCa and 15 patients with prostatitis) were recruited for this study. Magnetic resonance imaging (MRI) and MRS were performed using 1.5-T system GE- modle Optima 450 Discovery (GE Medical Systems, US). The (Cho+Cr)/Cit ratio of hypointense T2 areas were calculated. The diagnostic accuracy including sensitivity and specificity indices, with 0.95 confidence interval as well as PPV and NPV were calculated for each variable. The receiver operating characteristic (ROC) area under the curve (AUC) was outlined and investigated. The mean quantitative values between the two groups (PCa and Prostatitis) were compared using independent t test. RESULTS: The mean ratios of Cho+Cr/Cit in PCa was 1.54 ± 0.63 and 0.83 ± 0.48 for PCa and prostatitis, respectively, indicating a significant statistical difference (P = 0.00). A reduction in citrate was seen in both PCa and prostatitis tissue. Significant elevation in choline peak was shown for PCa. Moreover, creatinine level was low in both normal tissue and PCa without significant difference. Sensitivity, specificity, accuracy, PPV and NPV of MRS were 94.4% (95% CI, 74.2-99), 80% (95% CI, 54.8-93), 96%, 85% and 92.4%, respectively. CONCLUSION: The results of this study indicate an acceptable level of sensitivity, specificity and accuracy of MRS in the differential diagnosis of PCa and prostatitis.