RESUMEN

OBJECTIVE: Evaluation of serum and synovial fluid OPG and sRANKL in 37 patients with primary knee osteoarthritis. DESIGN AND METHOD: OPG and sRANKL were measured using ELISA. RESULTS: OPG, sRANKL and sRANKL/OPG were increased in osteoarthritis patients' serum. Synovial OPG was higher than serum OPG, while sRANKL/OPG was higher in the serum; both correlated with disease severity. DISCUSSION: RANKL/OPG pathway is implicated in the pathogenesis of knee osteoarthritis being a suitable target for therapeutic intervention.

Asunto(s)

Osteoartritis de la Rodilla/sangre , Osteoprotegerina/sangre , Ligando RANK/sangre , Receptor Activador del Factor Nuclear kappa-B/metabolismo , Índice de Severidad de la Enfermedad , Líquido Sinovial/metabolismo , Anciano , Anciano de 80 o más Años , Biomarcadores/sangre , Biomarcadores/metabolismo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Osteoartritis de la Rodilla/diagnóstico por imagen , Osteoartritis de la Rodilla/metabolismo , Osteoprotegerina/metabolismo , Ligando RANK/metabolismo , Radiografía , Líquido Sinovial/química