RESUMEN
[5-(Pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid arylidene-hydrazide derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed a feable activity against a strain of Mycobacterium tuberculosis and a strain of Mycobacterium avium.
Asunto(s)
Antibacterianos/síntesis química , Tiadiazoles/síntesis química , Antibacterianos/química , Antibacterianos/farmacología , Pruebas de Sensibilidad Microbiana , Mycobacterium/efectos de los fármacos , Relación Estructura-Actividad , Tiadiazoles/química , Tiadiazoles/farmacologíaRESUMEN
5-Aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. The compounds showed an interesting activity against a strain of Mycobacterium tuberculosis and a human strain of M. tuberculosis H4.
Asunto(s)
Antibacterianos/síntesis química , Antituberculosos/síntesis química , Pirazoles/síntesis química , Antibacterianos/química , Antibacterianos/farmacología , Antituberculosos/química , Antituberculosos/farmacología , Humanos , Pruebas de Sensibilidad Microbiana , Mycobacterium tuberculosis/efectos de los fármacos , Mycobacterium tuberculosis/aislamiento & purificación , Pirazoles/química , Pirazoles/farmacología , Relación Estructura-ActividadRESUMEN
6-[(Arylmethylenamino)carbonyl]-3-(pyridin-2-yl)-4H-1,2,4-triazin-5-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis.
Asunto(s)
Antituberculosos/farmacología , Triazinas/farmacología , Antituberculosos/síntesis química , Antituberculosos/química , Estructura Molecular , Mycobacterium avium/efectos de los fármacos , Mycobacterium tuberculosis/efectos de los fármacos , Triazinas/síntesis química , Triazinas/químicaRESUMEN
N1-[1-[3-aryl-1-(pyridin-2,3-, and 4-yl)-3-oxo[propyl]-2- pyridinecarboxamidrazone derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis and a strain of Mycobacterium avium.