RESUMEN

The indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid were synthesized and tested for diuretic activity in saline-loaded mice. Each analogue was found to be less active than the parent benzisoxazole: the diuretic activity followed the order O greater than S greater than N = SO2 in regard to the heteroatom in the 1-position of the ring.

Asunto(s)

Diuréticos/síntesis química , Isoxazoles , Oxazoles/síntesis química , Animales , Perros , Ratones , Natriuresis/efectos de los fármacos