RESUMEN

Usefulness of the pH-stat method for assaying the neutralizing activity of antacids was compared with the ones of the methods based on the determination of the action time by dynamic methods. A high level of correlation between the antacid dose and the neutralization capacity has been stated. The found relationships proved to enable optimization of the antacid dosage as well as prediction of the therapeutic effect.

Asunto(s)

Antiácidos/farmacología , Ácido Clorhídrico/antagonistas & inhibidores , Antiácidos/administración & dosificación , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Concentración de Iones de Hidrógeno , Técnicas In Vitro , Métodos , Factores de Tiempo