RESUMEN
This article presents a clinical case of urgent, life-saving surgical intervention in a 69-year-old woman with left atrial myxoma with rapid morphological and clinical progression and a history of COVID-19 and breast cancer in remission. However, the concurrent (perhaps secondary) thrombophilic condition facilitated the complication development in the form of superior vena caval orifice thrombosis in the early postoperative period. For this complication, repeated surgery in the volume of thrombectomy was performed, which resulted in stabilization of the patient's condition.
Asunto(s)
COVID-19 , Neoplasias Cardíacas , Mixoma , Anciano , COVID-19/complicaciones , Femenino , Atrios Cardíacos/diagnóstico por imagen , Atrios Cardíacos/patología , Neoplasias Cardíacas/complicaciones , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/cirugía , Humanos , Mixoma/complicaciones , Mixoma/diagnóstico , Mixoma/cirugía , Trombectomía/métodos , Vena Cava Superior/patologíaAsunto(s)
Amiodarona/farmacología , Antiarrítmicos/farmacología , Frecuencia Cardíaca/efectos de los fármacos , Corazón/fisiopatología , Contracción Miocárdica/efectos de los fármacos , Cardiopatía Reumática/fisiopatología , Estimulación Eléctrica , Corazón/efectos de los fármacos , Válvulas Cardíacas/cirugía , Ventrículos Cardíacos/efectos de los fármacos , Ventrículos Cardíacos/fisiopatología , Ventrículos Cardíacos/cirugía , Humanos , Técnicas In Vitro , Persona de Mediana Edad , Cardiopatía Reumática/cirugíaAsunto(s)
Linfocitos B/virología , Neoplasias de la Mama/virología , Linfoma no Hodgkin/virología , Virus del Tumor Mamario del Ratón/inmunología , Retroviridae/inmunología , Neoplasias de la Mama/sangre , Niño , Humanos , Sueros Inmunes , Linfoma no Hodgkin/sangre , Retroviridae/aislamiento & purificación , Proteínas Virales/inmunologíaRESUMEN
The paper presents a detailed clinical, hematological, morphological, ultrastructural and immunological characterisation of T-cell lymphosarcoma with prolymphocytic-lymphocytic leukemic transformation (PLLT). In PLLT the proportion of T-cell immunological subvariant of lymphosarcoma came to 15% being detected only in 8 out of 52 examinees. The patients (6 males and 2 females) varied in age from 24 to 76 years (median 49 years) and had the following histological forms of primary tumor tissue: lymphoblastic lymphosarcoma (n = 3), pleiomorphic small cell lymphosarcoma (n = 1), large-cell anaplastic lymphosarcoma (n = 1), prolymphocytic lymphosarcoma. Immunological characteristics of these 8 cases were heterogeneous: in lymphoblastic variant there was immature T-immunological phenotype. In pleomorphic small-cell lymphosarcoma there were also signs of T-cell activation. In large-cell anaplastic lymphosarcoma an immunological phenotype of lymphoid cells from the primary tumor tissue and bone marrow differed in more advanced immunological differentiation of bone marrow tumor cells. In prolymphocytic variant tumor cells had features of T-helpers or T-suppressors. Most of the patients received polychemotherapy according to the schemes for high-grade lymphosarcomas despite PLLT though the latter is not a universal indicator of late tumor progression, more aggressive course of the disease and poor prognosis.
Asunto(s)
Reacción Leucemoide/patología , Linfoma de Células T/patología , Linfocitos T/ultraestructura , Adulto , Anciano , Anciano de 80 o más Años , Antibióticos Antineoplásicos/administración & dosificación , Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Asparaginasa/administración & dosificación , Médula Ósea/inmunología , Médula Ósea/ultraestructura , Ciclofosfamida/administración & dosificación , Doxorrubicina/administración & dosificación , Femenino , Humanos , Inmunofenotipificación , Reacción Leucemoide/sangre , Reacción Leucemoide/tratamiento farmacológico , Reacción Leucemoide/inmunología , Linfoma de Células T/sangre , Linfoma de Células T/tratamiento farmacológico , Linfoma de Células T/inmunología , Masculino , Persona de Mediana Edad , Prednisolona/administración & dosificación , Linfocitos T/inmunología , Factores de Tiempo , Vincristina/administración & dosificaciónRESUMEN
This is the first presentation of information on the circulation of human herpes virus type 6 (HHV-6) in the population of the mid-European part of this country. The results of the study indicate that HHV-6 is widely spread both among apparently normal people and among patients with different pathologies. The studies using immunofluorescence test showed that the percentage of HHV-6-infected subjects was practically similar among blood donors, patients with nasopharyngeal cancer, rheumatoid arthritis, hemophilia, and patients with transplanted kidney, varying from 34% to 49%. A significantly higher per cent (66%) and higher antibody titres to HHV-6 were detected in sera from patients with hemoblastoses. A high level of HHV-6 infection among patients with hemoblastoses was also confirmed by the results of immunoblotting showing a wider spectrum and higher intensity of the detectable proteins. It should be noted that the amounts of virus-specific proteins detectable by some sera showed individual variations indicating different levels of expression of viral proteins in different individuals.
Asunto(s)
Herpesvirus Humano 6/aislamiento & purificación , Anticuerpos Antivirales/sangre , Especificidad de Anticuerpos , Artritis Reumatoide/inmunología , Donantes de Sangre/estadística & datos numéricos , Hemofilia A/inmunología , Infecciones por Herpesviridae/epidemiología , Infecciones por Herpesviridae/inmunología , Infecciones por Herpesviridae/microbiología , Herpesvirus Humano 6/inmunología , Humanos , Trasplante de Riñón/inmunología , Leucemia/inmunología , Neoplasias Nasofaríngeas/inmunología , Prevalencia , Federación de Rusia/epidemiología , Estudios SeroepidemiológicosAsunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Linfoma no Hodgkin/tratamiento farmacológico , Adolescente , Adulto , Anciano , Ciclofosfamida/administración & dosificación , Doxorrubicina/administración & dosificación , Evaluación de Medicamentos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Mitoxantrona/administración & dosificación , Mitoxantrona/efectos adversos , Prednisolona/administración & dosificación , Prednisona/administración & dosificación , Inducción de Remisión , Factores de Tiempo , Vincristina/administración & dosificaciónRESUMEN
Therapeutic-prophylactic measures in 60 patients were directed to remove the main pathogenetic mechanisms of development of lung emphysema (control of the obstructive syndrome, normalization of the sputum rheology, reduction of the protease level, restoration of the surfactant system activity). The efficacy of complex treatment (broncholytic agents, mucus regulators, protease inhibitors, etc.) depended largely on the necessity of active prophylactic medical care of patients with dust-induced bronchitis at early stages of the disease.
Asunto(s)
Bronquitis/terapia , Polvo/efectos adversos , Enfermedades Profesionales/terapia , Enfisema Pulmonar/terapia , Adulto , Anabolizantes/uso terapéutico , Bronquitis/complicaciones , Bronquitis/etiología , Bronquitis/prevención & control , Broncodilatadores/uso terapéutico , Terapia Combinada/métodos , Quimioterapia Combinada , Humanos , Persona de Mediana Edad , Enfermedades Profesionales/etiología , Enfermedades Profesionales/prevención & control , Terapia por Inhalación de Oxígeno , Inhibidores de Proteasas/uso terapéutico , Enfisema Pulmonar/etiología , Enfisema Pulmonar/prevención & controlRESUMEN
The study of surfactant effects and their biochemical composition in the expiration condensate covered 102 patients with dust bronchitis (DB). Decrease of surfactant effects and violation of the proportion of surfactant lipid fractions (increase in the percentage of free fat acids, triacylglyceride decrease) were noted along with the growth of DB severity and clearly defined pulmonary emphysema.