RESUMEN

Head and neck squamous cell carcinoma (HNSCC) is well known as a serious health problem worldwide, especially in low-income countries or those with limited resources, such as most countries in Latin America. International guidelines cannot always be applied to a population from a large region with specific conditions. This study established a Latin American guideline for care of patients with head and neck cancer and presented evidence of HNSCC management considering availability and oncologic benefit. A panel composed of 41 head and neck cancer experts systematically worked according to a modified Delphi process on (1) document compilation of evidence-based answers to different questions contextualized by resource availability and oncologic benefit regarding Latin America (region of limited resources and/or without access to all necessary health care system infrastructure), (2) revision of the answers and the classification of levels of evidence and degrees of recommendations of all recommendations, (3) validation of the consensus through two rounds of online surveys, and (4) manuscript composition. The consensus consists of 12 sections: Head and neck cancer staging, Histopathologic evaluation of head and neck cancer, Head and neck surgery-oral cavity, Clinical oncology-oral cavity, Head and neck surgery-oropharynx, Clinical oncology-oropharynx, Head and neck surgery-larynx, Head and neck surgery-larynx/hypopharynx, Clinical oncology-larynx/hypopharynx, Clinical oncology-recurrent and metastatic head and neck cancer, Head and neck surgery-reconstruction and rehabilitation, and Radiation therapy. The present consensus established 48 recommendations on HNSCC patient care considering the availability of resources and focusing on oncologic benefit. These recommendations could also be used to formulate strategies in other regions like Latin America countries.

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Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello , Humanos , Carcinoma de Células Escamosas de Cabeza y Cuello/terapia , América Latina/epidemiología , Consenso , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma de Células Escamosas/patología , Neoplasias de Cabeza y Cuello/terapia

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Abstract Introduction: The current standard treatment for bifurcation lesions is the provisional stent technique, by implanting only one stent in the main branch; however, in certain cases, the use of more complex techniques that require double stenting should be considered. Objective: To perform a clinical and angiographic assessment of patients with true bifurcation lesions treated with the two-stent culotte technique. Materials and methods: A prospective study was done, which included patients diagnosed with significant obstructive coronary artery disease in bifurcation areas, who were candidates for angioplasty with culotte technique. The study included 44 patients with proved diagnosis of coronary bifurcation lesions; 66% of the treated bifurcation lesions compromised the anterior descending artery and the diagonal branch and 27%, the circumflex artery with the marginal branch. It was found that 68% of the cases had Medina 1,1,1 lesions and 23% had Medina 0,1,1 lesions. Six months later, it was found that 12.5% of the patients followed up by angiography had in-stent restenosis (ISR) > 50% that involved at least one of the bifurcation areas. In 9% of these patients, the ISR was at the origin of the side branch only, and in 3%, the ISR was confined to the distal segment of the main branch stent. Conclusion: The use of the culotte technique with two new-generation stents to treat complex coronary bifurcation lesions is an effective option and does not increase the risk of complications during the procedure nor the risk of the appearance of ISR.

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Resumen Introducción: El tratamiento estándar actual para las lesiones en bifurcaciones es la técnica de stent provisional, implantando solo un stent en la rama principal, sin embargo, en ciertos casos, se debería considerar el uso de técnicas más complejas que requieren de doble stent. Objetivo: Realizar una evaluación clínica y angiográfica de pacientes con verdaderas lesiones en bifurcaciones tratados con la técnica culotte de doble stent. Material y métodos: Se realizó un estudio prospectivo que incluyó pacientes diagnosticados con enfermedad obstructiva significativa de arterias coronarias en bifurcaciones, quienes eran candidatos a angioplastia con la técnica culotte. El estudio incluyó 44 pacientes con un diagnóstico comprobado de lesiones coronarias en bifurcaciones; el 66% de las lesiones en bifurcaciones tratadas comprometían la arteria descendente anterior y la rama diagonal, y el 27% la arteria circunfleja con la rama marginal. Se encontró que el 68% de los casos tenían lesiones Medina 1,1,1 y el 23% tenían lesiones Medina 0,1,1. A los seis meses, se encontró que el 12,5% de los pacientes en seguimiento con angiografía presentaban reestenosis intrastent (RIS) mayor al 50%, que comprometía al menos una de las áreas de bifurcación. En el 9% de estos pacientes, la RIS se ubicaba únicamente en el origen de la rama lateral, y en el 3%, la RIS se restringió al segmento distal del stent de la rama principal. Conclusiones: El uso de la técnica culotte empleando dos stents de nueva generación es una opción efectiva para tratar las lesiones complejas en bifurcaciones coronarias, y no aumenta el riesgo de complicaciones durante el procedimiento ni el riesgo de la aparición de reestenosis intrastent.

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Argentina is a home to millions of beef and dairy cattle and is one of the world's major exporters of meat. In the present study, Trypanosoma vivax was prevalent (2016-2018) in two major livestock farming regions, the Gran Chaco and the Pampas. In the Gran Chaco, 29% and 51% of animals (n = 72, taurine x zebuine crossbreed) were, respectively, positive by TviCATL-PCR and the more sensitive fluorescent fragment length barcoding (FFLB) method. While 18.4/38.8% of breeding cows (n = 49) tested positive by PCR/FFLB, infection increased to 52.2/78.3% in an outbreak of acute infection in steers (n = 23, taurine breed) brought from a non-endemic area. In the Pampas, overall infection rates in dairy cows (n = 54, taurine breed) were comparable (p > .01) between PCR (66.7%) and FFLB (62.9%) and showed a remarkable increase (PCR / FFLB) from 48.3/44.8% in 2017 to 88/84% in 2018. Infected dairy cattle exhibited anaemia, fever, anorexia, enlarged lymph nodes, emaciation and neurological signs. In contrast, beef cows (taurine x zebuine crossbreed) from the Pampas (n = 30) were asymptomatic despite exhibiting 16.7% (PCR) and 53.3% (FFLB) infection rates. Microsatellite genotyping revealed a remarkable microheterogeneity, seven genotypes in the Gran Chaco, nine in the Pampas and five shared between both regions, consistent with regular movement of T. vivax infected livestock. Data gathered in our study support the Gran Chaco being an endemic area for T. vivax, whereas the Pampas emerged as an outbreak area of acute infection in dairy cattle with critical negative impact in milk production. To the best of our knowledge, this is the first molecular study of T. vivax in Argentina, and results indicated the need for preventive measures to control T. vivax spread from the Gran Chaco to vast livestock farming areas across Argentina.

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Bovinos , Brotes de Enfermedades , Trypanosoma vivax , Tripanosomiasis Africana , Animales , Argentina/epidemiología , Bovinos/parasitología , Brotes de Enfermedades/veterinaria , Femenino , Genotipo , Ganado , Trypanosoma vivax/genética , Tripanosomiasis Africana/veterinaria

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Rehydrated and ensiled mature ground corn has high ruminal starch digestibility, but particle size (PS) and dietary starch proportion (ST) can affect starch digestion and lactating cow performance. We evaluated the effect of rehydrated and ensiled corn (REC), PS, and ST on intake, lactation performance, nutrient digestibility, ruminal fermentation profile, and chewing behavior of dairy cows. Kernels from an 84% vitreousness hybrid were finely (FN) or coarsely (CS) ground, yielding geometric mean particle sizes of 1,591 and 2,185 µm, respectively. Ground kernels were rehydrated [60% dry matter (DM)] and ensiled in 200-L buckets for ≥205 d. The grinding rate (t/h) was 3.9 for FN and 11.7 for CS. The PS did not affect DM loss (11.3% of ensiled) or silage pH (3.8). Samples of each bucket (n = 15/PS) before and after silage fermentation were incubated in situ for 0, 3, 6, 18, and 48 h in 4 rumen-cannulated lactating cows. Ensiling increased the effective ruminal in situ DM degradation (63.7 vs. 34.1%), regardless of PS. Sixteen Holstein cows (152 ± 96 d in milk) in 4 × 4 Latin squares (21-d periods) were individually fed a 2 × 2 factorial combination of low (LO) or high (HI) starch diets with FN or CS. Cows were fed the same REC incubated in situ. Varied concentration of starch in the diet (29.2 vs. 23.5% of DM) was achieved by partial replacement of REC (22.0 vs. 14.2% of DM) with citrus pulp (0 vs. 8.2% of DM). Milk, protein, fat, and lactose yields did not differ. Milk fat percentage was reduced and protein percentage was increased by HI. Treatment FN increased feed efficiency (energy-corrected milk/digestible organic matter intake) when fed with HI. Total-tract starch digestibility tended to be reduced by CS (96.4 vs. 97.2% of starch intake). Serum ß-hydroxybutyrate was increased by LO. High-starch diet reduced the molar proportions of acetate and butyrate in ruminal fluid and increased propionate and isoacids. Particle size did not affect ruminal fermentation profile. Coarse grinding reduced plasma d-lactate concentration with HI. Diet HI reduced the proportion of daily intake from 1900 to 0700 h and induced preferential intake of feed particles <8 mm and greater refusal of particles >19 mm in the morning. Fine REC reduced rumination time per day and increased eating time per DM intake. Milk and plasma urea-N did not differ. Ensiling of mature flint corn for >200 d largely eliminated the effect of the PS of REC on the studied outcomes. The proportion of REC in the diet affected ruminal fermentation profile and milk solids concentration, but did not affect short-term performance and digestibility. Coarse grinding of REC may allow increasing the grinding rate and thus save labor and energy during ensiling.

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Bovinos/fisiología , Leche/química , Tamaño de la Partícula , Ensilaje/análisis , Zea mays , Alimentación Animal/análisis , Animales , Dieta/veterinaria , Digestión , Grano Comestible , Femenino , Fermentación , Lactancia , Lactosa/metabolismo , Leche/metabolismo , Distribución Aleatoria , Rumen/metabolismo , Almidón/análisis

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Novel core-shell superparamagnetic nanofluids composed of magnetic iron oxide (Fe3O4, MION) and cobalt-doped (CoxFe3-xO4, Co-MION) nanoparticles functionalized with carboxymethyl cellulose (CMC) ligands were designed and produced via green colloidal aqueous process. The effect of the degree of substitution (DS = 0.7 and 1.2) and molecular mass (Mw) of CMC and cobalt doping concentration on the physicochemical and magnetic properties of these nanoconjugates were comprehensively investigated using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, transmission electron microscopy (TEM) with selected area electron diffraction, X-ray fluorescence, dynamic light scattering (DLS), zeta potential (ZP) analysis, vibrating sample magnetometry (VSM) and electron paramagnetic resonance spectroscopy (EPR). The results demonstrated the effect of concentration of carboxylate groups and Mw of CMC on the hydrodynamic dimension, zeta potential, and generated heat by magnetic hyperthermia of MION nanoconjugates. Co-doping of MION showed significant alteration of the electrostatic balance of charges of the nanoconjugates interpreted as effect of surface interactions. Moreover, the VSM and EPR results proved the superparamagnetic properties of these nanocolloids, which were affected by the presence of CMC and Co-doping of iron oxide nanoparticles. These magnetic nanohybrids behaved as nanoheaters for killing brain cancer cells in vitro with prospective future applications in oncology and nanomedicine.

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Carboximetilcelulosa de Sodio/química , Carboximetilcelulosa de Sodio/farmacología , Nanopartículas de Magnetita/química , Nanocompuestos/química , Carboximetilcelulosa de Sodio/síntesis química , Línea Celular Tumoral , Técnicas de Química Sintética , Humanos , Fenómenos Magnéticos , Nanotecnología

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The supplementation of dairy cows with yeast culture may increase diet digestibility, plasma niacin concentration, heat dissipation, and lactation performance. Our objective was to evaluate the response of Holstein cows in late lactation (234 ± 131 d in milk) to dead yeast culture (YC, 15 g/d, Factor SC, GRASP, Saccharomyces cerevisiae) during Brazilian summer (temperature-humidity index >68 for 92.2% of the time). Thirty-two cows were individually fed a standard total mixed ration for 14 d and control (CTL) or YC treatments for 35 d, in a covariate adjusted complete randomized block design. Response was evaluated in wk 5 or as repeated measures over time. Cows were milked 3 times per day and treatments (YC or placebo) were orally dosed to each cow before each milking. Plasma niacin was 1.50 for CTL and 1.66 µg/mL for YC. The YC reduced rectal temperature, respiration rate, and skin temperature, whereas it tended to increase sweating rate. The proportion of cows with rectal temperature ≥39.2°C on CTL and YC was, respectively, 8 and 0% at 0730 h, 52 and 25% at 1500 h, and 35 and 26% at 2200 h. Plasma glucose was increased by YC. The total-tract apparent digestibility of nutrients, plasma urea N concentration, molar proportion of ruminal VFA, and urinary allantoin excretion were not affected by YC. Cows fed YC were less selective against feed particles >19 mm in the morning, in the afternoon were more selective against long feed particles and in favor of particles <8 mm, and refused short particles at night. Milk yield was not different (30.5 kg/d for CTL and 30.2 kg/d for YC). Feeding YC reduced dry matter intake (20.3 vs. 19.4 kg/d) and the digestible organic matter intake (15.6 vs. 13.9 kg/d). The inclusion of YC increased the ratios of milk to dry matter intake (1.50 vs. 1.64) and energy-corrected milk to dry matter intake (1.81 vs. 1.98). The covariate adjusted body weight (648 kg) and body condition score (3.0) did not differ. Milk solids yields and concentrations, linear somatic cell count, and milk urea N were also similar. The supplementation of YC increased plasma niacin concentration, body heat loss, and feed efficiency of late lactation dairy cows by reducing intake at similar milk yield.

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Bovinos/fisiología , Ingestión de Energía/fisiología , Lactancia/fisiología , Niacina/sangre , Levaduras/metabolismo , Alimentación Animal , Animales , Regulación de la Temperatura Corporal , Brasil , Dieta , Femenino , Leche , Rumen/metabolismo

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Oncolytic virotherapy is a novel strategy for treatment of cancer in humans and companion animals as well. Canine distemper virus (CDV), a paramyxovirus, has proven to be oncolytic through induction of apoptosis in canine-derived tumour cells, yet the mechanism behind this inhibitory action is poorly understood. In this study, three human mammary tumour cell lines and one canine-derived adenofibrosarcoma cell line were tested regarding to their susceptibility to CDV infection, cell proliferation, apoptosis, mitochondrial membrane potential and expression of tumour necrosis factor-alpha-induced protein 8 (TNFAIP8). CDV replication-induced cytopathic effect, decrease of cell proliferation rates, and >45% of infected cells were considered death and/or under late apoptosis/necrosis. TNFAIP8 and CDVM gene expression were positively correlated in all cell lines. In addition, mitochondrial membrane depolarization was associated with increase in virus titres (p < 0.005). Thus, these results strongly suggest that both human and canine mammary tumour cells are potential candidates for studies concerning CDV-induced cancer therapy.

Asunto(s)

Proteínas Reguladoras de la Apoptosis/metabolismo , Virus del Moquillo Canino/metabolismo , Viroterapia Oncolítica/veterinaria , Adenocarcinoma/terapia , Adenocarcinoma/veterinaria , Animales , Apoptosis , Neoplasias de la Mama/terapia , Muerte Celular , Línea Celular Tumoral , Proliferación Celular , Enfermedades de los Perros/terapia , Perros , Femenino , Humanos , Neoplasias Mamarias Animales/terapia , Viroterapia Oncolítica/métodos

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The phenylbenzothiazole compounds show antitumor properties and are highly selective. In this paper, the (99)Tc chemical shifts based on the ((99m)Tc)(CO)3 (NNO) complex conjugated to the antitumor agent 2-(4'-aminophenyl)benzothiazole are reported. Thermal and solvent effects were studied computationally by quantum-chemical methods, using the density functional theory (DFT) (DFT level BPW91/aug-cc-pVTZ for the Tc and BPW91/IGLO-II for the other atoms) to compute the NMR parameters for the complex. We have calculated the (99)Tc NMR chemical shifts of the complex in gas phase and solution using different solvation models (polarizable continuum model and explicit solvation). To evaluate the thermal effect, molecular dynamics simulations were carried, using the atom-centered density matrix propagation method at the DFT level (BP86/LanL2dz). The results highlight that the (99)Tc NMR spectroscopy can be a promising technique for structural investigation of biomolecules, at the molecular level, in different environments.

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Tecnecio/química , Temperatura , Tiazoles/química , Espectroscopía de Resonancia Magnética , Estructura Molecular , Teoría Cuántica , Solventes/química

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The aim of this study was to investigate the effect of Naringin on pre-neoplastic colorectal lesions induced by chemical carcinogen in rats. Female Wistar rats weighing 130.8±27.1 g received weekly one subcutaneous injection of 1,2-dimethylhydrazine (DMH, 20 mg/kg) for 10 weeks. The animals were divided into 5 groups with 6 animals in each group. Group 1: 0.9% saline; Group 2: DMH+0.9% saline; Group 3: DMH+Naringin (10 mg/kg); Group 4: DMH+Naringin (100 mg/kg); Group 5: DMH+Naringin (200 mg/kg). G2 and G3 showed a significant increase in ACF number, AgNOR/nucleus and mitosis compared to G1. G4 and G5 presented a significant reduction in these parameters compared to G2. The number of cells producing acidic and neutral mucins, red blood cells and the level of antioxidant minerals, such as copper, magnesium, selenium and zinc, were significantly reduced in G2 and G3, but similar in G4 and G5 compared to G1. Naringin, especially at 200 mg/kg, was effective in reducing the number of pre-neoplastic lesions in rats exposed to DMH. Some of these effects may be due to reduction in cellular proliferation and tissue levels of iron together with the recovery of antioxidant mineral levels induced by this flavonoid.

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Neoplasias Colorrectales/prevención & control , Flavanonas/farmacología , Lesiones Precancerosas/prevención & control , 1,2-Dimetilhidrazina/toxicidad , Animales , Carcinógenos/toxicidad , Neoplasias Colorrectales/inducido químicamente , Femenino , Ratones , Microscopía Electrónica de Rastreo , Lesiones Precancerosas/inducido químicamente , Ratas , Ratas Wistar

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Robinow syndrome is a genetically heterogeneous condition characterized by mesomelic limb shortening associated with facial and genital anomalies that can be inherited in an autosomal dominant or recessive mode. We characterized these two variants clinically, with the aim of establishing clinical criteria to enhance the differential diagnosis between them or other similar conditions. The frequencies of clinical signs considered important for the discrimination of the dominant or recessive variants were estimated in a sample consisting of 38 patients personally examined by the authors and of 50 affected subjects from the literature. Using the presence of rib fusions as diagnostic of the recessive variant, and also based on the inheritance pattern in familial cases, we classified 37 patients as having the recessive form and other 51 as having the dominant form. The clinical signs present in more than 75% of patients with either form, and therefore the most important for the characterization of this syndrome were hypertelorism, nasal features (large nasal bridge, short upturned nose, and anteverted nares), midface hypoplasia, mesomelic limb shortening, brachydactyly, clinodactyly, micropenis, and short stature. Hemivertebrae and scoliosis were present in more than 75% of patients with the recessive form, but in less than 25% of patients with the dominant form. Umbilical hernia (32.3%) and supernumerary teeth (10.3%) were found exclusively in patients with the dominant form.

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Anomalías Múltiples/diagnóstico , Anomalías Múltiples/genética , Anomalías Craneofaciales/diagnóstico , Genitales/anomalías , Deformidades Congénitas de las Extremidades/diagnóstico , Adolescente , Adulto , Niño , Preescolar , Anomalías Craneofaciales/genética , Diagnóstico Diferencial , Femenino , Genes Dominantes , Genes Recesivos , Humanos , Hipertelorismo/genética , Lactante , Deformidades Congénitas de las Extremidades/genética , Masculino , Síndrome

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Antecedentes: En los últimos años se ha introducido nuevos métodos para el estudio del colon. Objetivo: Analizar las distintas alternativas actuales para el diagnóstico de la patología colónica y el rol que el colon por enema (CxE) tiene en la actualidad, comparado con la videocolonoscopía (VCC), la colonoscopía virtual (CV) y la tomografía computada (TC). Material y métodos: Análisis de distintas series de la literatura que evalúan el papel de los diferentes métodos de estudio del colon. Resultados: Como estudio de catastro, la VCC y la CV fueron superiores en el diagnóstico de adenomas comparados con el CxE, que demostró una sensibilidad de alrededor del 50 por ciento según el tamaño de las lesiones con respecto a la VCC. Para pacientes sintomáticos, los resultados fueron similares. En pacientes ancianos, la TC mostró una sensibilidad comparable al CxE, no mostró el 2 por ciento de las lesiones radiológicas, sin las limitaciones de la preparación y la posibilidad de diagnóstico extracolónico. El CxE tiene utilidad en la colonoscopía incompleta pero compitiendo con la CV que tiene superior sensibilidad (50 contra 89 por ciento). Tiene mejor sensibilidad que la VCC en enfermedad diverticular (42 contra 18 casos), pero en patología asociada en colon sigmoideo, la sensibilidad es del 32 al 49 por ciento según el tamaño de las lesiones. La radiología aventaja a la VCC y CV en costo, siendo un 75 por ciento más económica. En series consultadas la indicación de CxE se ha reducido un 30 por ciento en los últimos 5 años. Conclusiones: El CxE tiene limitadas sus indicaciones en la actualidad y su utilización ha disminuido, siendo su futuro de indicación más restringida por el desarrollo y difusión de la VCC, el mejoramiento de la TC y el desarrollo de nuevos procedimientos como la CV.

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Background: New methods to study the colon have been introduced in recent years. Objective: To assess current different alternatives to study colonic diseases, and the barium enema (BE) role compared to videocolonoscopy (VCO), virtual colonoscopy (VC), and computed tomography (CT). Material and methods: Analysis of different series of the bibliography that evaluate the various methods of colon study. Results: In the screening studies, the VCO and the VC were superior for the diagnosis of adenomas compared with BE which demostrated a sensitivity of around 50 per cent, according to polyp size, with respect to the VCO. For symptomatic patients, the results were similar. In elderly patients, the CT showed a comparable sensitivity with BE, did not show 2 per cent of the radiological injuries, but without the limitations of the preparation and the possibility of extracolonic diagnosis. BE is useful in incomplete colonoscopy, however, compete with VC, which has superior sensitivity (50 vs. 89 per cent). BE has better sensitivity than VCO in diverticular disease (42 vs. 18 cases), but in associated in sigmoid colon pathology, sensitivity is 32 to 49 per cent according to the size of the polyps. Radiology surpasses VCO and VC in cost, being 75 per cent less expensive. According to reviewed series, the indication of BE has been reduced by 30 per cent in the last 5 years. Conclusions: currently, BE has limited indications, which will be more restricted in the future due to the development and diffusion of VCO, the improvement of the CT and the development of new procedures, such as the VC.

Asunto(s)

Humanos , Colon , Enema/métodos , Enfermedades del Colon/diagnóstico , Enfermedades del Colon , Colonografía Tomográfica Computarizada , Colonoscopía/métodos , Diagnóstico por Imagen/economía , Diagnóstico por Imagen/métodos , Divertículo del Colon/diagnóstico , Divertículo del Colon , Sangre Oculta , Sensibilidad y Especificidad , Tomografía Computarizada por Rayos X

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Introducción: La incidencia y la gravedad de las lesiones por proyectiles de armas de fuego (PAF) aumentaron considerablemente en los últimos años, con mayor impacto en las edades tempranas, siendo esta tendencia mundial. Pacientes y métodos: Estudiar los pacientes ingresados en nuestro hospital por PAF y compararlo con otras series. Diseño: retrospectivo. Población: 598 pacientes entre junio 1997 y junio 2004. Se considera: incidencia, sexo, edad, áreas de impacto, con un análisis especial en las lesiones de colón y recto, estudiando: topografía de las lesiones, asociación con otros órganos, estrategia terapéutica y morbimortalidad. Resultados: Total de pacientes 598, masculino: 513 (85,7 por ciento), femenino: 85 (14,3 por ciento). Edad promedio: 32,56 años, rango de 10 a 85. Areas de impacto: tronco 168 (28,08 por ciento), miembros: superiores 8 (14,04 por ciento), inferiores 334 (55,85 por ciento), compromiso colorrectal 29 (20 por ciento de las abdominales). Topografia: ciego 2 pacientes (6,8 por ciento), colon ascendente 1 (3,4 por ciento), ángulo hepático 2 (6,8 por ciento), transverso 4 (13,7 por ciento), ángulo esplénico 1 (3,4 por ciento), descendente 6 (20,6 por ciento), sigmoides 6 (20,6 por ciento) y recto 7 (24 por ciento). Órganos asociados: mesenterio e intestino delgado 8 pacientes, epiplón mayor 6, estómago 4, hígado 3, bazo 2, páncreas 2, vena ilíaca 3; arteria ilíaca 2, arteria aorta 1. Tratamientos realizados: cecostomía 2 pacientes, colostomía sobre varilla 9, exteriorización y cierre primario 4, operación tipo Lahey 4, operación tipo Hartmann 7, resección y anastomosis 3 y drenaje presacro 4 pacientes. Complicaciones: absceso de pared 8 pacientes (27,5 por ciento), peritonitis 4 (13,7 por ciento), evisceración 2 (6,8 por ciento), hemorragia 2 (6,8 por ciento), metabólicos 4 (13,7 por ciento). Mortalidad 2 pacientes. Discusión: en nuestra serie, 1 de cada 1200 admisiones en el servicio de emergencia correspondió a PAF, la mayoría, 69,89

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Humanos , Masculino , Adolescente , Adulto , Femenino , Niño , Persona de Mediana Edad , Anciano de 80 o más Años , Colon/lesiones , Heridas por Arma de Fuego/cirugía , Heridas por Arma de Fuego/diagnóstico , Heridas por Arma de Fuego/epidemiología , Heridas por Arma de Fuego/mortalidad , Recto/lesiones , Protocolos Clínicos , Servicio de Urgencia en Hospital , Tratamiento de Urgencia , Incidencia , Laparotomía , Pronóstico , Resucitación , Estudios Retrospectivos , Traumatismos Abdominales/cirugía , Traumatismos Abdominales/diagnóstico

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Este trabalho teve por objetivo comparar o efeito (uso tópico) da flunixina meglumina e da dexametasona no controle da uveíte anterior em cäes, por meio de avaliaçäo clínica e pela dosagem de proteínas no humor aquoso. Foram utilizados 17 cäes portadores de uveíte anterior de diversas etiologias. Os animais, divididos em dois grupos, foram tratados durante 15 dias. Observou-se maior eficácia da flunixina meglumina na cura clínica das uveítes e na reduçäo significativa da concentraçäo de proteínas no humor aquoso em relaçäo à dexametasona. Concluiu-se que a preparaçäo comercial de uso parenteral pode ser utilizada como colírio no tratamento de doenças inflamatórias da úvea

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Animales , Perros , Dexametasona , Uveítis Anterior , Soluciones Oftálmicas

RESUMEN

Este trabalho teve por objetivo comparar o efeito (uso tópico) da flunixina meglumina e da dexametasona no controle da uveíte anterior em cães, por meio de avaliação clínica e pela dosagem de proteínas no humor aquoso. Foram utilizados 17 cães portadores de uveíte anterior de diversas etiologias. Os animais, divididos em dois grupos, foram tratados durante 15 dias. Observou-se maior eficácia da flunixina meglumina na cura clínica das uveítes e na redução significativa da concentração de proteínas no humor aquoso em relação à dexametasona. Concluiu-se que a preparação comercial de uso parenteral pode ser utilizada como colírio no tratamento de doenças inflamatórias da úvea.(AU)

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The purpose of this study was to compare the effects of flunixin meglumine and dexamethasone topically for control of uveitis in dogs. Clinical evaluation and assessment of aqueous protein concentration were performed. Seventeen dogs with anterior uveitis secondary to variable ethiologies were studied. The animals were allotted in two groups and treated during 15 days. The flunixin meglumine was more efficient for induction of decrease in aqueous protein concentration, and control of uveitis when compared to dexamethasone. Thus, a parenteral solution of flunixin meglumine can be employed for the treatment of inflamatory uveal diseases.(AU)

Asunto(s)

Animales , Masculino , Femenino , Perros , Uveítis Anterior , Dexametasona , Soluciones Oftálmicas