RESUMEN
The pharmacokinetics of once a day netilmicin (6 mg/kg) was studied in 21 neonates. The babies were divided into three groups according to gestational age: group I aged > 36 weeks; group II between 34-36 weeks and group III < 34 weeks. Serum concentrations were variable between patients and the concentration 24 h after the first dose ranged from 0.8 to 3.8 mg/L with only two babies having concentrations of < 1 mg/L while seven had concentrations of > 2 mg/L. There were also large patient-to-patient variations in serum half-life, volume of distribution, area under the curve and relative plasma clearance such that these parameters could not be correlated to gestational age or weight. Absolute plasma clearance was correlated with both gestational age and weight. There was evidence of accumulation between the first and second dose for all three patient groups and for patients of gestational age < 34 weeks (group III) these observations were statistically significant. A netilmicin dosage of 4.5 mg/kg once a day may be more suitable for all neonates supported by assay of serum concentrations.
Asunto(s)
Netilmicina/administración & dosificación , Netilmicina/farmacocinética , Femenino , Gentamicinas/administración & dosificación , Gentamicinas/sangre , Gentamicinas/farmacocinética , Edad Gestacional , Humanos , Recién Nacido , Masculino , Netilmicina/sangre , Factores de TiempoRESUMEN
A small number of patients with haemangioma need treatment for serious complications such as Kasabach-Merritt syndrome, cardiac failure and obstruction of the airway. We report on the management of an infant with Kasabach-Merritt syndrome.
Asunto(s)
Antineoplásicos/uso terapéutico , Neoplasias Faciales/terapia , Hemangioma Cavernoso/terapia , Interferón-alfa/uso terapéutico , Trombocitopenia/terapia , Humanos , Recién Nacido , Masculino , SíndromeAsunto(s)
Bacterias Aerobias/aislamiento & purificación , Cateterismo Venoso Central/veterinaria , Enfermedades de los Caballos/microbiología , Tromboflebitis/veterinaria , Animales , Cateterismo Venoso Central/efectos adversos , Corynebacterium/aislamiento & purificación , Enterobacter/aislamiento & purificación , Enfermedades de los Caballos/etiología , Caballos , Staphylococcus/aislamiento & purificación , Streptococcus/aislamiento & purificación , Tromboflebitis/etiología , Tromboflebitis/microbiologíaRESUMEN
Proximal enteritis was diagnosed on the basis of clinical signs of disease in 2 Standard-bred yearlings from the same farm. Large volumes of fluid were repeatedly obtained during gastric decompression. The horses did not respond to treatment with IV administered fluids, antimicrobial agents, cimetidine, and metoclopramide. Postmortem findings confirmed severe focal chronic active duodenitis with stricture formation. An etiologic agent was not identified.