RESUMEN
BACKGROUND: Mammary analogue secretory carcinoma (MASC) is a newly recognized salivary gland tumor that harbors a characteristic balanced chromosomal translocation t (12; 15) (p13; q25) resulting in an ETV6-NTRK3 fusion gene. METHODS: Retrospective study of 111 salivary gland carcinomas revealed 37 cases with secretory features and growth patterns resembling secretory carcinoma of breast. These 37 cases were originally diagnosed as acinic cell carcinoma, adenocarcinoma not otherwise specified and cystadenocarcinoma. Positive immunostaining for S-100 protein and mammaglobin, followed by detection of ETV6 gene rearrangement by FISH and/or ETV6-NTRK3 fusion transcript by RT-PCR were used to identify MASCs. RESULTS: In the cohort of 37 salivary carcinomas with secretory features we have identified 10 cases of MASC. All 10 MASCs were positive for mammaglobin, S-100 protein and SOX10, while staining for DOG1 and p63 protein were mostly absent. In 7/10 cases, both FISH and RT-PCR were positive while three remaining cases showed break of ETV6 gene by FISH analysis and the RT-PCR was negative. Clinical follow-up data were obtained in 6 out of 10 patients with MASC. In 3 patients cervical lymph node metastases developed, one patient with high grade transformed MASC died with multiple distant bone metastases, and local recurrence was observed in three patients. CONCLUSION: Our clinicopathological data are in keeping with previous studies; in most cases, MASC is a low-grade malignancy with overall favorable prognosis. In rare cases, however, MASC with high-grade transformation may behave aggressively, and these patients could benefit from targeted biological treatment using tyrosine kinase inhibitors.
Asunto(s)
Carcinoma Secretor Análogo al Mamario/genética , Carcinoma Secretor Análogo al Mamario/patología , Neoplasias de las Glándulas Salivales/genética , Neoplasias de las Glándulas Salivales/patología , Adulto , Anciano , Biomarcadores de Tumor/análisis , Femenino , Reordenamiento Génico , Humanos , Masculino , Persona de Mediana Edad , Proteínas de Fusión Oncogénica/genética , Proteínas Proto-Oncogénicas c-ets/genética , Proteínas Represoras/genética , Estudios Retrospectivos , Adulto Joven , Proteína ETS de Variante de Translocación 6RESUMEN
OBJECTIVES: The aim of this survey was to investigate the primary reason for extraction of permanent teeth, its correlations with age, gender and education level, as well as identify the important predictors for dental caries in general dental centers in Tehran, Iran. SUBJECTS AND METHODS: The study was conducted over a period of 6 months; its population consisted of 1,382 patients, aged 9-95 years, who underwent tooth extraction. There were 673 (47.8%) male and 709 (51.3%) female patients. The frequency distribution was calculated using the χ(2) test, ANOVA and t test for differences in mean number of extracted teeth and the logistic regression model to evaluate the variables associated with reasons for tooth extraction. RESULTS: A total of 2,620 teeth were extracted from the 1,382 patients. The highest rate (36.9%) of extraction occurred for those 41-60 years old. Males comprised 48.7% of patients but had more teeth (1,470, 55.3%) extracted than females (1,150, 43.9%). Nine hundred and thirty-six (67.7%) patients had incomplete secondary education or less. Tooth loss due to caries was 51%; periodontal disease was 14.4%; supernumerary and tooth impaction 13.9%. There was a significant association between patient characteristics (age, gender and education level) and number of teeth extracted. CONCLUSION: Dental caries and periodontal disease were the main reasons for tooth extraction in Tehran, Iran.