RESUMEN
This observational study was conducted in 235 patients undergoing IVF who had a cervical swab positive for Chlamydia trachomatis and who underwent antibiotic treatment until a negative cervical swab before IVF attempt. After oocyte retrieval, follicular fluids of 109 patients out of 228 still showed the presence of IgA antichlamydia antibodies and a significantly lower pregnancy and implantation rate; therefore we conclude that patients should undergo IVF procedure after serum antichlamydia IgA tests negative.
Asunto(s)
Autoinmunidad , Cuello del Útero/microbiología , Infecciones por Chlamydia/microbiología , Chlamydia trachomatis/aislamiento & purificación , Implantación del Embrión , Fertilización In Vitro , Índice de Embarazo , Antibacterianos/uso terapéutico , Anticuerpos Antibacterianos/metabolismo , Infecciones por Chlamydia/tratamiento farmacológico , Infecciones por Chlamydia/inmunología , Chlamydia trachomatis/inmunología , Femenino , Líquido Folicular/inmunología , Líquido Folicular/microbiología , Humanos , Inmunoglobulina A/sangre , Italia , Recuperación del Oocito , Embarazo , Factores de TiempoRESUMEN
PURPOSE: To evaluate the effect of the depth of embryo transfer replacement on clinical pregnancy rate. METHODS: Data from a total of 104 consecutive embryo transfers performed on 104 women aged 26-37 years were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes retrieval were performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups according to the distance between the tip of the catheter and the uterine fundus at transfer (group A > 10 < 15 mm and group B < or = 10 mm). The same method of loading embryos into the embryo transfer catheter was used. RESULTS: Clinical pregnancy rates varied significantly (p < or = 0.05) between the two groups: 27.7% in group A and 14% in group B. The number and quality of embryos transferred did not differ between the groups. CONCLUSIONS: The results suggest that the depth of embryo replacement may be an important variable in embryo transfer technique.
Asunto(s)
Embrión de Mamíferos/fisiología , Fertilización In Vitro/métodos , Resultado del Embarazo , Adulto , Estradiol/sangre , Femenino , Hormona Folículo Estimulante/sangre , Humanos , Infertilidad Femenina/clasificación , EmbarazoRESUMEN
OBJECTIVE: The following study was conducted to determine which FSH, recombinant or urinary, works better in older women. DESIGN: We conducted a controlled randomized study in a single university IVF center. SETTING: University IVF center. PATIENT(S): Women (N = 257) over 39 years old undergoing IVF. INTERVENTION(S): The patients were randomized into two study groups at their first IVF cycle: 121 patients were treated with recombinant FSH, and 120 patients were treated with urinary FSH. Both groups were suppressed with a long GnRH analog protocol. MAIN OUTCOME MEASURE(S): Days of stimulation, E2 at the day of hCG, total amount of FSH administered, number of oocytes collected, amount of FSH per oocyte, and number of embryos obtained. RESULT(S): Patients treated with urinary FSH required a significantly lower total amount of FSH, and a lower amount of FSH per oocyte than women treated with recombinant FSH. The other measures evaluated did not show any statistically significant differences. CONCLUSION(S): Our study showed that urinary FSH performed better in older women than recombinant FSH when associated with the long protocol.