RESUMEN

13,14-Dihydroxy-8,11,13-podocarpatrien-7-one (1) and a series of ring C aromatic diterpene derivatives were synthesised from (+)-manool (4) and evaluated for their cytotoxic, leishmanicidal and trypanocidal activities. Our results indicated that compound 1 and other podocarpane-type intermediates are cytotoxic. Cleavage of C6-C7 bond of compound 7 improved cytotoxic activity, indicating that, in particular, the 6,7-seco-podocarpane-type compound 20 might serve as a lead compound for further development.

Asunto(s)

Antiprotozoarios/farmacología , Diterpenos/química , Diterpenos/síntesis química , Tripanocidas/farmacología , Diterpenos/farmacología , Fibroblastos/efectos de los fármacos , Humanos , Concentración 50 Inhibidora , Leishmania mexicana/efectos de los fármacos , Células MCF-7 , Estructura Molecular , Trypanosoma cruzi/efectos de los fármacos