RESUMEN
The effects of serotonin on gut motility have been both excitatory and inhibitory. The purpose of the present study was to elucidate how serotonin influences motor activity in two functionally different parts of the stomach. Pressure recordings were made from fundic and antral pouches of isolated guinea pig whole stomach preparations. In the fundus serotonin induced relaxation, which developed gradually within 3 min. In the antrum serotonin initiated phasic contractions, which culminated within 3 min and then returned to near or below prestimulatory values. Whereas tetrodotoxin did not significantly reduce the fundic relaxation, the antral excitation was strongly inhibited by both atropine and tetrodotoxin, indicating different effect mechanisms in fundus and antrum.
Asunto(s)
Motilidad Gastrointestinal/efectos de los fármacos , Serotonina/farmacología , Animales , Atropina/farmacología , Relación Dosis-Respuesta a Droga , Fundus Gástrico/efectos de los fármacos , Fundus Gástrico/inervación , Cobayas , Vías Nerviosas/efectos de los fármacos , Antro Pilórico/efectos de los fármacos , Antro Pilórico/inervación , Tetrodotoxina/farmacologíaRESUMEN
While guinea-pig stomachs were isolated and oxygenated in organ baths. Continuous pressure recordings were made from separate fundic and antral pouches. Prostaglandin F2 alpha stimulated motor activity in both fundus and antrum mainly by elevation of wall tension, whereas the amplitude or frequency of the rhythmic activity was not significantly affected. The responses were dose-dependent and not significantly inhibited by atropine, mepyramine, or cimetidine. A direct effect mechanism of PGF2 alpha, independent of intramural cholinergic or histaminergic pathways, is indicated for both fundus and antrum.
Asunto(s)
Motilidad Gastrointestinal/efectos de los fármacos , Prostaglandinas F/farmacología , Animales , Atropina/farmacología , Cimetidina/farmacología , Dinoprost , Relación Dosis-Respuesta a Droga , Fundus Gástrico/efectos de los fármacos , Fundus Gástrico/inervación , Cobayas , Vías Nerviosas/efectos de los fármacos , Antro Pilórico/efectos de los fármacos , Antro Pilórico/inervación , Pirilamina/farmacología , Receptores Colinérgicos/efectos de los fármacos , Receptores Histamínicos/efectos de los fármacosRESUMEN
A case of acute jejunogastric intussusception is reported. The patient had suffered intermittent attacks for 7 years, and had an acute fulminating attack prior to the present admission. Chronic recurrent jejunogastric intussusception should be considered a possible cause of pain and vomiting in patients who have had gastrojejunostomy or gastric resection.