RESUMEN
Over the period of cadmium poisoning and its counteracting by selenium the activity of erythrocyte enzymes (lactate dehydrogenase and catalase) and the methemoglobin level have been studied. Selenium was found to have protective effect on stabilization of metabolic processes in erythrocytes that prevents the development of oxidation stress and hypoxia.
Asunto(s)
Antioxidantes/uso terapéutico , Intoxicación por Cadmio/sangre , Eritrocitos/metabolismo , Selenito de Sodio/uso terapéutico , Animales , Intoxicación por Cadmio/tratamiento farmacológico , Catalasa/metabolismo , Modelos Animales de Enfermedad , Eritrocitos/efectos de los fármacos , Eritrocitos/enzimología , L-Lactato Deshidrogenasa/metabolismo , Masculino , Metahemoglobina/análisis , RatasRESUMEN
The effect of cadmium chloride on the fatty acid composition of lipids of the erythrocytes and blood plasma has been studied. It has been established that in the process of cadmium intoxication the decrease of the level of unsaturated fatty acids takes place and the most considerable changes in the content of oleic and arachidonic acids. It makes possible to assume the disturbance of both the erythrocytes membrane structure and metabolism in the erythrocyte. Unitiol injection promotes the normalisation of the indices under investigation.
Asunto(s)
Intoxicación por Cadmio/sangre , Quelantes/uso terapéutico , Membrana Eritrocítica/efectos de los fármacos , Ácidos Grasos/sangre , Unitiol/uso terapéutico , Animales , Cloruro de Cadmio/toxicidad , Intoxicación por Cadmio/tratamiento farmacológico , Modelos Animales de Enfermedad , Membrana Eritrocítica/metabolismo , Ácidos Grasos/química , Ácidos Grasos/metabolismo , Masculino , RatasRESUMEN
Cadmium intoxication has been defined to make material changes in hemoglobin system by elevation of sulfhemoglobin and methhemoglobin levels on the back-cloth of lowering of general hemoglobin. Alongside with the latter there is observed a violation of antioxydation protection including the activity of erythrocytic catalase, ceruloplasmin, ferrum saturation of transferrine.