RESUMEN
Although low back pain (LBP) is a widespread and disabling health problem, there is a lack of evidence based medicine with respect to its treatment and rehabilitation. A major reason for this is the poor understanding of the underlying mechanisms of the LBP syndromes. In an attempt to fill this gap, the present review article provides an overview of the sensory-motor control aspects of trunk stabilization and postural control of the trunk, and how they may relate to the evolution of LBP. In particular, the anatomy and physiology of the sensory-motor control mechanisms of the trunk muscles that contribute to general and segmental stability of the lumbar spine will be elucidated. Furthermore, a brief overview of current theories of postural control will be provided with respect to spinal stabilization. Finally, a concept of the pathophysiological changes within the sensory-motor control mechanisms of the lumbar spine in the presence of muscle injury and pain will be presented. The impact of pain and muscle injury on the muscular support for the lumbar motion segment will be discussed along with the deficits in neuromuscular control in LBP patients with decreased segmental lumbar stability.
Asunto(s)
Dolor de la Región Lumbar/fisiopatología , Dolor de la Región Lumbar/rehabilitación , Región Lumbosacra/anatomía & histología , Región Lumbosacra/fisiología , Postura/fisiología , Músculos Abdominales/fisiología , Traumatismos de la Espalda/fisiopatología , Traumatismos de la Espalda/rehabilitación , Diafragma/fisiología , Terapia por Ejercicio/métodos , Humanos , Contracción Muscular/fisiología , Músculo Esquelético/patología , Músculo Esquelético/fisiología , Columna Vertebral/inervación , Columna Vertebral/fisiologíaRESUMEN
OBJECTIVES: The aim of the study was to investigate the effects of different loads on tremor around 10 Hz during fatiguing contractions. METHODS: Eighteen healthy volunteers performed sustained isometric knee extensions at 30%, 50% and 70% maximum voluntary contraction (MVC). During the fatiguing contractions, mechanical recordings were made with a high-resolution force sensor. Tremor-power was calculated for the 6-20 Hz frequency window as a function of time normalized to endurance time. RESULTS: Initial tremor power was different between the high and low load tasks. Changes of tremor with contraction time differed between the three tasks, in that tremor of the 30% MVC contraction showed the least decrease throughout the sustained contraction, whilst that of the 50% and 70% MVC showed progressively higher decreases. At failure, all 3 contractions merged to the same tremor level. CONCLUSION: Load-dependent, fatigue-related 6-20 Hz tremor changes during sustained submaximum voluntary contractions seem mainly the consequence of recruitment of new units and fatigue-related properties of the high threshold motor units of muscles.
Asunto(s)
Contracción Isométrica/fisiología , Fatiga Muscular/fisiología , Desempeño Psicomotor/fisiología , Temblor , Adulto , Femenino , Lateralidad Funcional , Humanos , Articulación de la Rodilla , Masculino , Actividad Motora , Resistencia Física , Valores de Referencia , Descanso , Soporte de PesoRESUMEN
It was hypothesized that the age-related alterations in the morphological properties of a motor unit would be accompanied by modifications in the control aspects of the motor unit, as either an adaptive or compensatory mechanism to preserve smooth force production. In specific, the objective of the study was to investigate the age-related alterations in the concurrent firing behavior of multiple motor units in the first dorsal interosseous (FDI) muscle in isometric contractions at 20 and 50% of the subject's voluntary contraction level. Analysis of the data collected from 10 young (24-37 yr of age) and 10 elderly (65-88 yr of age) subjects led to three novel observations regarding the firing behavior of aged motor units. 1) Among elderly subjects, there is a decrease in the common fluctuations that are observed among the firing rates of motor units in the young. 2) The relationship observed between the firing rate and recruitment threshold of young subjects is disturbed in the elderly. Although in young subjects, at any point in a given submaximal contraction, earlier recruited motor units have higher firing rates than later-recruited units; in aged subjects this dependency of firing rate on recruitment rank is compromised. 3) The progressive decrease observed in the firing rates of concurrently active motor units in constant-force contractions in the young is not seen in the aged. In addition to these original findings, this study provided support for earlier reports of 1) decreased average firing rates probably reflecting the slowing of the muscle, 2) a shift in recruitment thresholds toward lower force levels in line with the shift toward type I fibers, and 3) multiphasic action potential shapes indicative of the reinnervation process that takes place during aging. Taken as a whole, these findings indicate significant age-related modifications in the control properties of human motor units.
Asunto(s)
Envejecimiento/fisiología , Contracción Isométrica/fisiología , Neuronas Motoras/fisiología , Músculo Esquelético/fisiología , Adulto , Anciano , Anciano de 80 o más Años , Electromiografía , Dedos/inervación , Humanos , Tiempo de Reacción/fisiología , Análisis de RegresiónRESUMEN
Daily preferential use was shown to alter physiological and mechanical properties of skeletal muscle. This study was aimed at revealing differences in the control strategy of muscle pairs in humans who show a clear preference for one hand. We compared the motor unit (MU) recruitment and firing behavior in the first dorsal interosseous (FDI) muscle of both hands in eight male volunteers whose hand preference was evaluated with the use of a standard questionnaire. Myoelectric signals were recorded while subjects isometrically abducted the index finger at 30% of the maximal voluntary contraction (MVC) force. A myoelectric signal decomposition technique was used to accurately identify MU firing times from the myoelectric signal. In MUs of the dominant hand, mean values for recruitment threshold, initial firing rate, average firing rate at target force, and discharge variability were lower when compared with the nondominant hand. Analysis of the cross-correlation between mean firing rate and muscle force revealed cross-correlation peaks of longer latency in the dominant hand than in the nondominant side. This lag of the force output with respect to fluctuations in the firing behavior of MUs is indicative of a greater mechanical delay in the dominant FDI muscle. MVC force was not significantly different across muscle pairs, but the variability of force at the submaximal target level was higher in the nondominant side. The presence of lower average firing rates, lower recruitment thresholds, and greater firing rate/force delay in the dominant hand is consistent with the notion of an increased percentage of slow twitch fibers in the preferentially used muscle, allowing twitch fusion and force buildup to occur at lower firing rates. It is suggested that a lifetime of preferred use may cause adaptations in the fiber composition of the dominant muscle such that the mechanical effectiveness of its MUs increased.
Asunto(s)
Dedos/fisiología , Lateralidad Funcional/fisiología , Neuronas Motoras/fisiología , Potenciales de Acción/fisiología , Adulto , Electromiografía , Humanos , Contracción Isométrica/fisiología , Masculino , Fatiga Muscular/fisiología , Músculo Esquelético/fisiologíaRESUMEN
1. The purpose of this study was 1) to characterize the decrease observed in mean firing rates of motor units in the first 8-15 s of isometric constant-force contractions and 2) to investigate possible mechanisms that could account for the ability to maintain force output in the presence of decreasing motor unit firing rates. 2. The decrease in mean firing rates was characterized by investigating myoelectric signals detected with a specialized quadrifilar needle electrode from the first dorsal interosseus (FDI) and the tibialis anterior (TA) muscles of 19 healthy subjects during a total of 85 constant-force isometric contractions at 30, 50, or 80% of maximal effort. The firing times of motor units were obtained from the myoelectric signals with the use of computer algorithms to decompose the signal into the constituent motor unit action potentials. Time-varying mean firing rates and recruitment thresholds were also calculated. 3. Motor units detected from the TA muscle were found to have a continual decrease in their mean firing rates in 36 of 44 trials performed during isometric ankle dorsiflexion at force values ranging from 30 to 80% of maximal effort and a duration of 8-15 s. Likewise, motor units detected in the FDI muscle displayed a decrease in firing rate in 32 of 41 trials performed during constant-force isometric index finger abduction for contractions ranging from 30 to 80% of maximal effort. In 14 contractions (16% of total), firing rates were essentially constant, whereas in 3 contractions (4%), firing rates appeared to increase. 4. Motor units with the higher recruitment thresholds and lower firing rates tended to display the greater decreases in firing rate over the constant-force interval, whereas motor units with lower recruitment thresholds and higher firing rates had lesser rates of decrease. Furthermore, increasing contraction levels tended to intensify the decrease in the motor unit firing rates. 5. Three possible mechanisms were considered as factors responsible for the maintaining of force output while motor units decreased their firing rates: motor unit recruitment, agonist/antagonist interaction, and twitch potentiation. Of these, motor unit recruitment was discarded first because none was observed during the 8-15 s duration of any of the 85 contractions. Furthermore, contractions outside the physiological range of motor unit recruitment (at 80% of maximal effort) revealed the same decreasing trend in firing rates, ruling out recruitment as the means of sustaining force output. 6. The role of agonist or antagonist muscle interaction was investigated with the use of the muscles controlling the wrist joint. Myoelectric signals were recorded with quadrifilar needle electrodes from the wrist extensor muscles while myoelectric activity in the wrist flexor muscles was concurrently monitored with surface electrodes during constant-force isometric wrist extension at 50% of maximal effort. Firing rates of the motor units in the wrist extensor muscles simultaneously decreased while the flexor muscles were determined to be inactive. 7. All the findings of this study regarding the behavior of the firing rates could be well explained by the reported characteristics of twitch potentiation that have been previously documented in animals and humans. 8. The results of this study, combined with the results of other investigators, provide the following scenario to explain how a constant-force isometric contraction is sustained. As the contraction progresses, the twitch force of the muscle fibers undergoes a potentiation followed by a decrease. Simultaneously, the "late adaptation" property of the motoneuron decreases the firing rate of the motor unit. Findings of this study suggest that voluntary reduction in firing rates also cannot be ruled out as a means to augment the adaptation in motoneurons. (ABSTRACT TRUNCATED)
Asunto(s)
Contracción Isométrica/fisiología , Neuronas Motoras/fisiología , Músculo Esquelético/inervación , Adulto , Brazo/inervación , Brazo/fisiología , Electrofisiología , Humanos , Pierna/inervación , Pierna/fisiología , Músculo Esquelético/citología , Músculo Esquelético/fisiología , Reclutamiento Neurofisiológico/fisiología , Muñeca/inervación , Muñeca/fisiologíaRESUMEN
Myoelectric signals were detected from the tibialis anterior muscle of 5 subjects with a quadrifilar needle electrode while the subjects generated isometric forces that increased linearly with time (10% of maximal voluntary contraction/s) up to maximal voluntary level. Motor unit firing rates were studied as a function of force throughout the full range of muscle force output. The relationship between force and firing rate was found to contain three distinct regions. At recruitment and near maximal force levels, firing rates increased more rapidly with force than in the intermediate region. Furthermore, in the regions with rapid increases, the rate of change of firing rate was correlated to the recruitment threshold, with higher recruitment threshold motor units displaying greater rates of change. In the intermediate region, all motor units had similar rates of change of firing rate. A weak positive correlation was found between initial firing rate and recruitment threshold. Firing rates of motor units at any instant were found to be ordered according to the recruitment order: at any given time in the contraction motor units with lower recruitment thresholds had higher firing rates than units with higher recruitment thresholds. Firing rates of all motor units were observed to converge to the same value at maximal forces. Mechanisms underlying motor unit recruitment and firing rate modulation are discussed in the context of a conceptual model.
Asunto(s)
Neuronas Motoras/fisiología , Potenciales de Acción , Adulto , Umbral Diferencial , Humanos , Pierna , Contracción Muscular/fisiología , Músculos/inervación , Reclutamiento NeurofisiológicoRESUMEN
The neuromuscular system is responsible for all our interactions with our environment. Although recent decades have witnessed numerous discoveries that have shed light into various properties of this system, the basic principles underlying its overall operation still remain poorly understood. In this article, Carlo J. De Luca and Zeynep Erim discuss the concept of common drive of motor units that provides a possible scheme for the control of motor units, unifying various seemingly isolated findings that have been reported. According to this concept, a pool of motor units that makes up a muscle is controlled collectively during a contraction of that muscle. The unique firing patterns of individual motor units are effected, not by separate command signals sent to these units, but by one common drive to which motor units respond differently. The specific architecture of the system and the orderly gradation in the inherent properties of individual elements enable a single source to control the activities of all the motor units in a given pool. Such an arrangement relieves the CNS from the burden of monitoring and regulating each motor unit separately.
Asunto(s)
Neuronas Motoras/fisiología , Músculos/fisiología , Animales , Electrofisiología , Humanos , Modelos Neurológicos , Contracción Muscular/fisiologíaRESUMEN
1. Synchronization of concurrently active motor-unit firings was studied in six human muscles performing isometric constant-force contractions at 30% of the maximal level. The myoelectric signal was detected with a quadrifilar needle electrode and was decomposed into its constituent motor-unit action-potential trains with the Precision Decomposition technique, whose accuracy has been proven previously. 2. Synchronization was considered as the tendency of two motor units to fire at fixed time intervals with respect to each other more often than would be expected if the motor units fired independently. A rigorous statistical technique was used to measure the presence of peaks in the cross-interval histogram of pairs of motor-unit action-potential trains. The location of the center of peak as well as their width and amplitude were measured. A synch index was developed to measure the percentage of firings that were synchronized. The percentage of concurrently active motor-unit pairs that contained synchronized firings was measured. 3. Synchronization of motor-unit firings was observed to occur in two modalities. The short-term modality was seen as a peak in the cross-interval histogram centered about zero-time delay (0.5 +/- 2.9 ms, mean +/- SD) and with an average width of 4.5 +/- 2.5 ms. The long-term modality was seen as a peak centered at latencies ranging from 8 to 76 ms. On the average, the peaks of the long-term synchronization were 36% lower but had approximately the same width as the peaks for the short-term synchronization. Short-term synchronization was seen in 60% of the motor-unit paris, whereas long-term synchronization was seen in 10% of the pairs. 4. Short-term synchronization occurred in bursts of consecutive firings, ranging in number from 1 to 10, with 91% of all synchronized firing occurring in groups of 1 or 2; and the bursts of discharges appeared at sporadic times during the contraction. 5. The amount of synchronization in motor-unit pairs was found to be low. In the six muscles that were tested, an average of 8.0% of all the firings were short-term synchronized, and an average of 1.0% were long-term synchronized. The synch index was statistically indistinguishable (P = 0.07-0.89) among the different muscles and among 9 of the 11 subjects tested. 6. Sixty percent of concurrently active motor-unit pairs displayed short-term synchronization, 10% of the pairs displayed long-term synchronization, and 8% displayed both modalities.(ABSTRACT TRUNCATED AT 400 WORDS)