RESUMEN
BACKGROUND: The purpose of this study was to evaluate the effects of intravenous zoledronic acid applied systemically on osseointegration of dental implants and the surrounding bone mineral density (BMD) in the ovariectomized rats. MATERIAL AND METHODS: 36 rats were divided into three groups: control (CTRL), ovariectomy (OVX), and ovariectomy-zoledronic acid (OVX/ZOL). The rats in the CTRL group underwent sham surgery, while rats in OVX and OVX / ZOL group underwent ovariectomy. After 12 weeks, rats from OVX / ZOL were injected with 0.04 mg/kg ZOL intravenously once a week for 6 weeks. The rats from CTRL and OVX groups were injected with 0.9% NaCl. Implants were placed in the left tibia. After 8 weeks, rats were sacrificed and tibia bones were removed for radiodensitometric examination. Digital radiographs of bones' lateral surface were taken. The BMD was measured by using radiographic analysis software. RESULTS: Statistically significant differences were found between all groups (p<0.05). While highest mean BMD values were observed in the CTRL group, the lowest were in the OVX group. CONCLUSIONS: The systemic use of ZOL has increased the bone density around the implants inserted osteoporotic rat tibia.
Asunto(s)
Conservadores de la Densidad Ósea/administración & dosificación , Densidad Ósea/efectos de los fármacos , Implantes Dentales , Difosfonatos/administración & dosificación , Imidazoles/administración & dosificación , Oseointegración/efectos de los fármacos , Absorciometría de Fotón , Animales , Femenino , Ovariectomía , Ratas , Ratas Wistar , Ácido ZoledrónicoRESUMEN
The purpose of this study was to evaluate the effect of microgap on clinical and biochemical parameters around dental implants for 1 year. All patients received four implants: group A-Standard Straumann(®) implants, group B-1 mm subcrestal placement of the polished surface of group A implants, group C-esthetic plus Straumann® implants, group D-subcrestal placement of the polished surface of group C implants. Clinical measurements and peri-implant crevicular fluid (PICF) were collected immediately before loading and at 3rd, 6th, and 12th months after loading, and interleukin-1 beta (IL-1ß) and tumor necrosis factor-alpha (TNF-α) have been assessed in the crevicular fluid. No significant differences were found in plaque index, gingival index, and probing between the groups throughout the study. However, the PICF volumes of group D were significantly higher than that in the other groups, and group A were significantly lower than the other groups (P < 0.05). With respect to bleeding on probing values, the percentage of BOP (+) sides in group A implants were fewer than group C and D implants (P < 0.05). With regard to IL-1ß, the levels of IL-1ß in group A were lower than that in the other groups during the study (P < 0.05). In point of TNF-α total amounts, the levels of TNF-α in group A implants were lower than those in group B and D implants (P < 0.05). Moving microgap coronally from alveolar crest could be recommended for the health of periodontal tissues. Most coronal location of microgap can be suggested in order to maintain the peri-implant health status, particularly in implant sites without esthetic priority.
Asunto(s)
Diseño de Implante Dental-Pilar , Líquido del Surco Gingival/inmunología , Interleucina-1beta/análisis , Factor de Necrosis Tumoral alfa/análisis , Implantes Dentales , Índice de Placa Dental , Prótesis Dental de Soporte Implantado , Femenino , Estudios de Seguimiento , Hemorragia Gingival/clasificación , Humanos , Mediadores de Inflamación/análisis , Masculino , Persona de Mediana Edad , Índice Periodontal , Bolsa Periodontal/clasificación , Estudios Prospectivos , Propiedades de SuperficieRESUMEN
PURPOSE: To evaluate effects of mobile phone use on brain tissue and a possible protective role of vitamin C. MATERIALS AND METHODS: Forty female rats were divided into four groups randomly (Control, mobile phone, mobile phone plus vitamin C and, vitamin C alone). The mobile phone group was exposed to a mobile phone signal (900 MHz), the mobile phone plus vitamin C group was exposed to a mobile phone signal (900 MHz) and treated with vitamin C administered orally (per os). The vitamin C group was also treated with vitamin C per os for four weeks. Then, the animals were sacrificed and brain tissues were dissected to be used in the analyses of malondialdehyde (MDA), antioxidant potential (AOP), superoxide dismutase, catalase (CAT), glutathione peroxidase (GSH-Px), xanthine oxidase, adenosine deaminase (ADA) and 5'nucleotidase (5'-NT). RESULTS: Mobile phone use caused an inhibition in 5'-NT and CAT activities as compared to the control group. GSH-Px activity and the MDA level were also found to be reduced in the mobile phone group but not significantly. Vitamin C caused a significant increase in the activity of GSH-Px and non-significant increase in the activities of 5'-NT, ADA and CAT enzymes. CONCLUSION: Our results suggest that vitamin C may play a protective role against detrimental effects of mobile phone radiation in brain tissue.
Asunto(s)
Ácido Ascórbico/farmacología , Encéfalo/efectos de los fármacos , Encéfalo/efectos de la radiación , Teléfono Celular , Protectores contra Radiación/farmacología , Ondas de Radio/efectos adversos , 5'-Nucleotidasa/metabolismo , Adenosina Desaminasa/metabolismo , Animales , Antioxidantes/metabolismo , Encéfalo/metabolismo , Catalasa/metabolismo , Femenino , Glutatión Peroxidasa/metabolismo , Malondialdehído/metabolismo , Modelos Animales , Ratas , Ratas Wistar , Superóxido Dismutasa/metabolismo , Xantina Oxidasa/metabolismoRESUMEN
AIM: To examine the possible effects of honey supplementation on hepatic damage due to obstruction of the common bile duct in an experimental rat model. METHODS: The study was performed with 30 male rats divided into three groups: a sham group, an obstructive jaundice group, and an obstructive jaundice plus honey group. At the end of the study period, the animals were sacrificed, and levels of nitric oxide (NO), and NO synthase (NOS) activities were measured in liver tissues, and levels of adenosine deaminase (ADA) and alanine transaminase (ALT) activities were measured in serum. RESULTS: Blood ALT and ADA activities were significantly elevated in the jaundice group as compared to those of the sham group. In the obstructive jaundice plus honey group, blood ALT and ADA activities were significantly decreased as compared to those of the jaundice group. In erythrocytes and liver tissues, NO levels were found to be significantly higher in the obstructive jaundice plus honey group compared to those of the sham group. Additionally, NO levels were found to be significantly higher in liver tissues from the animals in the obstructive jaundice plus honey group than those of the jaundice group. CONCLUSION: Honey was found to be beneficial in the prevention of hepatic damage due to obstruction of the common bile duct.
Asunto(s)
Colestasis/complicaciones , Miel , Ictericia Obstructiva/tratamiento farmacológico , Hígado/efectos de los fármacos , Sustancias Protectoras/farmacología , Adenosina Desaminasa/sangre , Alanina Transaminasa/sangre , Animales , Colestasis/tratamiento farmacológico , Colestasis/metabolismo , Colestasis/patología , Conducto Colédoco/cirugía , Modelos Animales de Enfermedad , Ictericia Obstructiva/etiología , Ictericia Obstructiva/metabolismo , Ictericia Obstructiva/patología , Ligadura , Hígado/enzimología , Hígado/patología , Masculino , Óxido Nítrico/metabolismo , Óxido Nítrico Sintasa/metabolismo , Ratas , Ratas WistarRESUMEN
AIM: Methotrexate (MTX), a folic acid antagonist, is one of the chemotherapeutic agents widely used in the treatment of some types of cancers. Nephrotoxicity is one of the complications of MTX treatment. The aim of this study was to investigate possible effects of MTX treatment on the oxidant/antioxidant status in rat kidney tissues and enzymatic mechanisms leading to nephrotoxicity. METHODS: For this aim, 10 Sprague-Dawley type female rats of 4 weeks old were used in the study. The animals were divided into two groups randomly. Five of them were used as control, and the others were treated with MTX intravenously (60 mg/m2 of body surface area per week) for 7 weeks. At the end of this period, they were sacrificed, and kidney tissues were removed to be used in the analyses of malondialdehyde (MDA) levels, antioxidant potential (AOP) values, and superoxide dismutase, catalase, glutathione peroxidase, xanthine oxidase, adenosine deaminase, and 5' nucleotidase enzyme activities. RESULTS: There was significant increase in the MDA level in the MTX group compared with the control group (1.74+/-0.23 nmol/mg vs. 1.04+/-0.30 nmol/mg; p<0.05, respectively). There were however no meaningful differences between enzyme activities and AOP values of the groups. CONCLUSION: It has been suggested that MTX leads to oxidative stress in rat kidney tissues, which might be one of the reasons for MTX-induced nephrotoxicity.