RESUMEN
Background: Herpes zoster (HZ) is typically characterized by a burning, stabbing pain, hyperalgesia, and allodynia. In some patients, despite the lesions resolving, the pain persists and becomes chronic. If the pain continues for more than 6 months after the onset of the pain phase, this condition is called postherpetic neuralgia (PHN). The frequency and severity of PHN increase with advancing age. The pain in PHN can be severe, sometimes resistant to medications, significantly impacting the patients' quality of life. The elderly patient population cannot tolerate the medications due to their side effects. In this situation, interventional pain treatment should be applied in the elderly patient group who have a high risk of developing PHN compared to other age groups. Method: We included patients over 65 years of age with HZ-related pain who underwent dorsal root ganglion (DRG) pulsed radiofrequency (PRF) within the first 6 months from the onset of pain. We divided these patients into 2 groups: patients who underwent intervention within the first 1 month from the onset of pain and patients who underwent intervention between 1 and 6 months. We recorded medication doses and Numeric Rating Scale (NRS) scores before the procedure and at 1 week, 1 month, 3 months, and 6 months after the procedure. Results: After the DRG PRF treatment, NRS scores improved significantly in both groups (p < 0.05). The mean NRS score in the early DRG PRF group was significantly lower than that in the late DRG PRF group (p < 0.05). The medication doses in the early DRG PRF group were significantly lower than those in the other group (p < 0.05). Conclusions: Interventional pain treatment should be applied as soon as possible in the elderly patient group who do not respond to first-line medical treatment or cannot tolerate medical treatment due to its side effects and who have a high risk of developing PHN compared to other age groups. DRG PRF, applied in the early period of medical treatment-resistant acute HZ, is safe and effective, preventing the progression to PHN.
Asunto(s)
Ganglios Espinales , Herpes Zóster , Neuralgia Posherpética , Tratamiento de Radiofrecuencia Pulsada , Humanos , Anciano , Masculino , Femenino , Tratamiento de Radiofrecuencia Pulsada/métodos , Neuralgia Posherpética/terapia , Herpes Zóster/complicaciones , Anciano de 80 o más Años , Dimensión del Dolor , Resultado del Tratamiento , Manejo del Dolor/métodosRESUMEN
The modern approach to the management of pain involves optimizing all aspects of the process. This includes utilization of pharmacologic and non-pharmacologic modalities, consideration of patient characteristics, proper matching of the physiology of the pain with the analgesic's mechanism of action (pharmacodynamics, PD), and the onset and duration of action (pharmacokinetics, PK). No single agent or formulation satisfies all of the requirements for all patients. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are effective options for inflammatory pain and, as is acetaminophen, for mild pain. Specialized agents are helpful for particular pains, such as for migraine headache. Opioids remain the standard option for severe pain. Although they are generally a safe and effective option, opioids can produce dose-limiting adverse effects and have abuse potential. The goal of pain therapy is thus to achieve the maximum pain relief with the least amount of opioid exposure. Against this background of measured approach to the use of analgesics, an immediate release (IR) oral formulation of the established opioid oxycodone has been developed to provide rapid onset of action and rate of titration, both of which could maximize temporal matching of dose with pain level and reduce total exposure to drug. This article considers the option of an immediate release (IR) oral formulation for the management of pain.
Asunto(s)
Analgésicos Opioides/administración & dosificación , Oxicodona/administración & dosificación , Dolor/prevención & control , Administración Oral , Analgésicos Opioides/efectos adversos , Química Farmacéutica , Preparaciones de Acción Retardada , Humanos , Oxicodona/efectos adversosRESUMEN
Pulsed radiofrequency (PRF) fields applied by an electrode to neural structures, such as the peripheral sensory nociceptor axons and dorsal root ganglion, are clinically effective in reducing pain and other neuropathic syndromes. However, a full understanding of the underlying mechanisms by which this occurs has not yet been clarified. In this study, PRF is applied to the afferent axons of the sciatic nerves of rats. A standard radiofrequency (RF) electrode and RF generator is used to apply the RF signal output to the sciatic nerve using standard PRF parameters that have been successfully used in clinical practice. The ultrastructure of the treated axons is observed after 10 days by electron microscopy. A control, sham application is simultaneously applied to the contralateral sciatic nerve to provide a statistical differential comparison. It is found that the internal ultrastructural components of the axons show microscopic damage after PRF exposure, including: abnormal membranes and morphology of mitochondria, and disruption and disorganization of microfilaments and microtubules. The damage appears to be more pronounced for C-fibers than for A-delta and A-beta fibers. The results are discussed in terms of internal electric field strengths and thermodynamic parameters.
Asunto(s)
Axones/ultraestructura , Ondas de Radio , Nervio Ciático/citología , Nervio Ciático/efectos de la radiación , Citoesqueleto de Actina/efectos de la radiación , Citoesqueleto de Actina/ultraestructura , Animales , Axones/efectos de la radiación , Masculino , Microscopía Electrónica de Transmisión/métodos , Microtúbulos/efectos de la radiación , Microtúbulos/ultraestructura , Mitocondrias/efectos de la radiación , Fibras Nerviosas/efectos de la radiación , Fibras Nerviosas/ultraestructura , Ratas , Ratas WistarRESUMEN
OBJECTIVE: Use of analgesics has been increasingly recognized as a major public health issue with important consequences in Turkey. The objective of the study was to determine the prevalence and patterns of analgesics usage and associated factors in adults with pain complaints. METHODS: A cross-sectional study was conducted in 15 cities selected from five demographic regions in Turkey. The study sample population comprised 1.909 adults 18-65 age groups suffering from pain. The sampling method was multi-step stratified weighted quota-adjusted sampling. Data were collected by face-to-face interviews using a semi-structured survey questionnaire consisting of 28 questions. Odds ratios were produced by logistic regression analyses. RESULTS: The prevalence of analgesic use was 73.1 percent, and it was higher in females (75.7 percent; p<0.05), in subjects 45-54 years (81.4 percent; p<0.05), in subjects in rural areas (74.6 percent; p<0.05), in subjects in northern region (84.3 percent; p<0.05), in illiterate subjects (79.1 percent; p>0.05), and in subjects of lower socioeconomic status (74.1 percent; p>0.05). One in ten of the participants used non-prescription analgesics. Non-prescription analgesics were more prevalent among the 55-65 age groups (18.1 percent; p<0.05), among female (11.6 percent; p>0.05), among the urban population (10.7 percent; p>0.05), and in subjects of lower middle socioeconomic status (13.2 percent; p<0.05). Logistic regression showed statistically significant ORs only for age groups, duration of education, socioeconomic status, and demographic regions (p<0.05). CONCLUSIONS: The results showed that the prevalence of analgesic use and prescription analgesic use is high in Turkey, and their use is related to sociodemographic characteristics.
OBJETIVO: O uso de analgésicos tem sido amplamente reconhecido com um grande problema de saúde pública com importantes conseqüências na Turquia. O objetivo do estudo foi determinar a prevalência e os padrões de uso de analgésicos por adultos e os fatores associados às queixas de dores. MÉTODOS: Estudo transversal conduzido em 15 cidades selecionadas de cinco regiões demográficas da Turquia. A amostra estudada incluiu grupos etários de 1.909 adultos (18-65 anos) que sofrem de dores. O método de amostragem seguiu estratificação com pesos ajustados para cada estrato amostrado. Os dados foram coletados em entrevistas face-a-face, usando um questionário de levantamento semi-estruturado, composto por 28 questões. Foram calculados os odds raios por meio de regressão logística. RESULTADOS: A prevalência de uso de analgésicos foi de 73,1 por cento, sendo significativamente (p<0,05) maior em mulheres (75,7 por cento; p<0,05), em sujeitos de 45-54 anos (81,4 por cento; p<0,05), naqueles residentes em área rural (74,6 por cento; p<0,05), na região norte (84,3 por cento; p<0.05), em analfabetos (79,1 por cento; p>0,05), e em sujeitos de status socioeconômico mais baixo (74,1 por cento; p>0,05). Um em cada dez participantes usou analgésico sem prescrição médica. A não-prescrição foi mais prevalente entre sujeitos do grupo etário 55-65 (18,1 por cento; p<0,05), entre mulheres (11,6 por cento; p>0,05), entre a população urbana (10,7 por cento; p>0,05), e em sujeitos de classe econômica média-baixa (13,2 por cento; p<0,05). A regressão logística mostrou OR significantes apenas para grupos etários, anos de estudo, status socioeconômico e região demográfica (p<0,05). CONCLUSÕES: Os resultados mostraram que a prevalência de uso de analgésico e sua prescrição de uso são altas na Turquia, e esses usos são relacionados a características sociodemográficas.
OBJETIVO: El uso de analgésicos ha sido reconocido como el mayor problema de salud pública con importantes consecuencias en Turquía. El objetivo del estudio fue determinar la prevalencia y patrones de uso de analgésicos y factores asociados en adultos que padecen de dolores. MÉTODOS: Se condujo un estudio transversal en 15 ciudades seleccionadas de cinco regiones demográficas en Turquía. La muestra poblacional comprendió 1.909 adultos agrupados en edades entre 18-65 años que sufrían de dolor. Se realizó un muestreo multi-etapa estratificado ajustado. Los datos fueron colectados en entrevistas cara a cara usando un cuestionario semi-estructurado que consistía de 28 preguntas. Los Odds ratio fueron obtenidos por análisis de regresión logística. RESULTADOS: La prevalencia en el uso de analgésicos fue de 73,1 por ciento y fue superior en mujeres (75,7 por ciento; p<0,05), en individuos con edades entre 45-54 años (81,4 por ciento; p<0,05), en individuos de áreas rurales (74,6 por ciento; p<0,05), en individuos de la región norte (84,3 por ciento; p<0,05), en analfabetas (79,1 por ciento; p<0,05) y en individuos de clase social baja (74,1 por ciento; p<0,05). Uno de cada diez de los participantes usa analgésicos sin prescripción médica. La no prescripción médica fue más prevalente en los grupos entre 55-65 años (18,1 por ciento; p<0,05), entre mujeres (11,6 por ciento; p<0,05), entre la población urbana (10,7 por ciento; p<0,05) y en individuos de clase media y baja (13,2 por ciento; p<0,05). La regresión logística mostró ORs significativos estadísticamente sólo para grupos etarios, duración de la educación, status socioeconómico, y regiones demográficas (p<0,05). CONCLUSIONES: Los resultados mostraron que la prevalencia del uso de analgésico y prescripción para el uso de analgésicos es alta en Turquía, y su uso esta relacionado con características sociodemográficas.
Asunto(s)
Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven , Analgésicos/uso terapéutico , Dolor/tratamiento farmacológico , Distribución por Edad , Demografía , Prescripciones de Medicamentos/estadística & datos numéricos , Escolaridad , Métodos Epidemiológicos , Medicamentos sin Prescripción/uso terapéutico , Dolor/epidemiología , Población Rural/estadística & datos numéricos , Distribución por Sexo , Clase Social , Factores Socioeconómicos , Turquía/epidemiología , Población Urbana/estadística & datos numéricos , Adulto JovenRESUMEN
OBJECTIVE: Use of analgesics has been increasingly recognized as a major public health issue with important consequences in Turkey. The objective of the study was to determine the prevalence and patterns of analgesics usage and associated factors in adults with pain complaints. METHODS: A cross-sectional study was conducted in 15 cities selected from five demographic regions in Turkey. The study sample population comprised 1.909 adults 18-65 age groups suffering from pain. The sampling method was multi-step stratified weighted quota-adjusted sampling. Data were collected by face-to-face interviews using a semi-structured survey questionnaire consisting of 28 questions. Odds ratios were produced by logistic regression analyses. RESULTS: The prevalence of analgesic use was 73.1%, and it was higher in females (75.7%; p<0.05), in subjects 45-54 years (81.4%; p<0.05), in subjects in rural areas (74.6%; p<0.05), in subjects in northern region (84.3%; p<0.05), in illiterate subjects (79.1%; p>0.05), and in subjects of lower socioeconomic status (74.1%; p>0.05). One in ten of the participants used non-prescription analgesics. Non-prescription analgesics were more prevalent among the 55-65 age groups (18.1%; p<0.05), among female (11.6%; p>0.05), among the urban population (10.7%; p>0.05), and in subjects of lower middle socioeconomic status (13.2%; p<0.05). Logistic regression showed statistically significant ORs only for age groups, duration of education, socioeconomic status, and demographic regions (p<0.05). CONCLUSIONS: The results showed that the prevalence of analgesic use and prescription analgesic use is high in Turkey, and their use is related to sociodemographic characteristics.
Asunto(s)
Analgésicos/uso terapéutico , Dolor/tratamiento farmacológico , Adolescente , Adulto , Distribución por Edad , Anciano , Demografía , Prescripciones de Medicamentos/estadística & datos numéricos , Escolaridad , Métodos Epidemiológicos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Medicamentos sin Prescripción/uso terapéutico , Dolor/epidemiología , Población Rural/estadística & datos numéricos , Distribución por Sexo , Clase Social , Factores Socioeconómicos , Turquía/epidemiología , Población Urbana/estadística & datos numéricos , Adulto JovenRESUMEN
Interventional techniques are divided into two categories: neuroablative and neuromodulatory procedures. Neuroablation is the physical interruption of pain pathways either surgically, chemically or thermally. Neuromodulation is the dynamic and functional inhibition of pain pathways either by administration of opioids and other drugs intraspinally or intraventricularly or by stimulation. Neuroablative techniques for cancer pain treatment have been used for more than a century. With the development of imaging facilities such as fluoroscopy, neuroablative techniques can be performed more precisely and efficiently.
Asunto(s)
Analgésicos Opioides/uso terapéutico , Dolor/tratamiento farmacológico , Dolor/prevención & control , Técnicas de Ablación/métodos , Electrocoagulación , Humanos , Neoplasias/fisiopatología , Bloqueo Nervioso/métodos , Dolor/cirugía , SimpatectomíaRESUMEN
SUMMARY OF CONSENSUS: 1. The use of opioids in cancer pain: The criteria for selecting analgesics for pain treatment in the elderly include, but are not limited to, overall efficacy, overall side-effect profile, onset of action, drug interactions, abuse potential, and practical issues, such as cost and availability of the drug, as well as the severity and type of pain (nociceptive, acute/chronic, etc.). At any given time, the order of choice in the decision-making process can change. This consensus is based on evidence-based literature (extended data are not included and chronic, extended-release opioids are not covered). There are various driving factors relating to prescribing medication, including availability of the compound and cost, which may, at times, be the main driving factor. The transdermal formulation of buprenorphine is available in most European countries, particularly those with high opioid usage, with the exception of France; however, the availability of the sublingual formulation of buprenorphine in Europe is limited, as it is marketed in only a few countries, including Germany and Belgium. The opioid patch is experimental at present in U.S.A. and the sublingual formulation has dispensing restrictions, therefore, its use is limited. It is evident that the population pyramid is upturned. Globally, there is going to be an older population that needs to be cared for in the future. This older population has expectations in life, in that a retiree is no longer an individual who decreases their lifestyle activities. The "baby-boomers" in their 60s and 70s are "baby zoomers"; they want to have a functional active lifestyle. They are willing to make trade-offs regarding treatment choices and understand that they may experience pain, providing that can have increased quality of life and functionality. Therefore, comorbidities--including cancer and noncancer pain, osteoarthritis, rheumatoid arthritis, and postherpetic neuralgia--and patient functional status need to be taken carefully into account when addressing pain in the elderly. World Health Organization step III opioids are the mainstay of pain treatment for cancer patients and morphine has been the most commonly used for decades. In general, high level evidence data (Ib or IIb) exist, although many studies have included only few patients. Based on these studies, all opioids are considered effective in cancer pain management (although parts of cancer pain are not or only partially opioid sensitive), but no well-designed specific studies in the elderly cancer patient are available. Of the 2 opioids that are available in transdermal formulation--fentanyl and buprenorphine--fentanyl is the most investigated, but based on the published data both seem to be effective, with low toxicity and good tolerability profiles, especially at low doses. 2. The use of opioids in noncancer-related pain: Evidence is growing that opioids are efficacious in noncancer pain (treatment data mostly level Ib or IIb), but need individual dose titration and consideration of the respective tolerability profiles. Again no specific studies in the elderly have been performed, but it can be concluded that opioids have shown efficacy in noncancer pain, which is often due to diseases typical for an elderly population. When it is not clear which drugs and which regimes are superior in terms of maintaining analgesic efficacy, the appropriate drug should be chosen based on safety and tolerability considerations. Evidence-based medicine, which has been incorporated into best clinical practice guidelines, should serve as a foundation for the decision-making processes in patient care; however, in practice, the art of medicine is realized when we individualize care to the patient. This strikes a balance between the evidence-based medicine and anecdotal experience. Factual recommendations and expert opinion both have a value when applying guidelines in clinical practice. 3. The use of opioids in neuropathic pain: The role of opioids in neuropathic pain has been under debate in the past but is nowadays more and more accepted; however, higher opioid doses are often needed for neuropathic pain than for nociceptive pain. Most of the treatment data are level II or III, and suggest that incorporation of opioids earlier on might be beneficial. Buprenorphine shows a distinct benefit in improving neuropathic pain symptoms, which is considered a result of its specific pharmacological profile. 4. The use of opioids in elderly patients with impaired hepatic and renal function: Functional impairment of excretory organs is common in the elderly, especially with respect to renal function. For all opioids except buprenorphine, half-life of the active drug and metabolites is increased in the elderly and in patients with renal dysfunction. It is, therefore, recommended that--except for buprenorphine--doses be reduced, a longer time interval be used between doses, and creatinine clearance be monitored. Thus, buprenorphine appears to be the top-line choice for opioid treatment in the elderly. 5. Opioids and respiratory depression: Respiratory depression is a significant threat for opioid-treated patients with underlying pulmonary condition or receiving concomitant central nervous system (CNS) drugs associated with hypoventilation. Not all opioids show equal effects on respiratory depression: buprenorphine is the only opioid demonstrating a ceiling for respiratory depression when used without other CNS depressants. The different features of opioids regarding respiratory effects should be considered when treating patients at risk for respiratory problems, therefore careful dosing must be maintained. 6. Opioids and immunosuppression: Age is related to a gradual decline in the immune system: immunosenescence, which is associated with increased morbidity and mortality from infectious diseases, autoimmune diseases, and cancer, and decreased efficacy of immunotherapy, such as vaccination. The clinical relevance of the immunosuppressant effects of opioids in the elderly is not fully understood, and pain itself may also cause immunosuppression. Providing adequate analgesia can be achieved without significant adverse events, opioids with minimal immunosuppressive characteristics should be used in the elderly. The immunosuppressive effects of most opioids are poorly described and this is one of the problems in assessing true effect of the opioid spectrum, but there is some indication that higher doses of opioids correlate with increased immunosuppressant effects. Taking into consideration all the very limited available evidence from preclinical and clinical work, buprenorphine can be recommended, while morphine and fentanyl cannot. 7. Safety and tolerability profile of opioids: The adverse event profile varies greatly between opioids. As the consequences of adverse events in the elderly can be serious, agents should be used that have a good tolerability profile (especially regarding CNS and gastrointestinal effects) and that are as safe as possible in overdose especially regarding effects on respiration. Slow dose titration helps to reduce the incidence of typical initial adverse events such as nausea and vomiting. Sustained release preparations, including transdermal formulations, increase patient compliance.
Asunto(s)
Analgésicos Opioides/administración & dosificación , Analgésicos Opioides/farmacocinética , Dolor/tratamiento farmacológico , Dolor/metabolismo , Organización Mundial de la Salud , Factores de Edad , Anciano , Anciano de 80 o más Años , Analgésicos Opioides/efectos adversos , Buprenorfina/administración & dosificación , Buprenorfina/efectos adversos , Buprenorfina/farmacocinética , Enfermedad Crónica , Ensayos Clínicos como Asunto/métodos , Manejo de la Enfermedad , Fentanilo/administración & dosificación , Fentanilo/efectos adversos , Fentanilo/farmacocinética , Humanos , Hidromorfona/administración & dosificación , Hidromorfona/efectos adversos , Hidromorfona/farmacocinética , Internacionalidad , Metadona/administración & dosificación , Metadona/efectos adversos , Metadona/farmacocinética , Morfina/administración & dosificación , Morfina/efectos adversos , Morfina/farmacocinética , Oxicodona/administración & dosificación , Oxicodona/efectos adversos , Oxicodona/farmacocinética , Dolor/epidemiología , Dimensión del Dolor/efectos de los fármacos , Dimensión del Dolor/métodos , Dimensión del Dolor/normasAsunto(s)
Dolor , Adulto , Anciano , Enfermedad Crónica , Femenino , Humanos , Masculino , Medicina , Clínicas de Dolor , EspecializaciónRESUMEN
The aim of this prospective, randomized, double-blinded study was to evaluate the effect of pulsed radiofrequency (PRF) in comparison with conventional radiofrequency (CRF) in the treatment of idiopathic trigeminal neuralgia. A total of 40 patients with idiopathic trigeminal neuralgia were included. The 20 patients in each group were randomly assigned to one of the two treatment groups. Each patient in the Group 1 was treated with CRF, whereas each patient in the Group 2 was treated by PRF. Evaluation parameters were: pain intensity using a Visual Analogue Scale (VAS), patient satisfaction using a Patient Satisfaction Scale (PSS), additional pharmacological treatment, side effects, and complications related to the technique. The VAS scores decreased significantly (p<0.001) and PSS improved significantly after the procedure in Group 1. The VAS score decreased in only 2 of 20 patients from the PRF group (Group 2) and pain recurrence occurred 3 months after the procedure. At the end of 3 months, we decided to perform CRF in Group 2, because all patients in this group still had intractable pain. After the CRF treatment, the median VAS score decreased (p<0.001) and PSS improved (p<0.001) significantly. In conclusion, the results of our study demonstrate that unlike CRF, PRF is not an effective method of pain treatment for idiopathic trigeminal neuralgia.
Asunto(s)
Ablación por Catéter/métodos , Nervio Trigémino/cirugía , Neuralgia del Trigémino/cirugía , Adulto , Anciano , Anciano de 80 o más Años , Método Doble Ciego , Electrodos/normas , Femenino , Humanos , Masculino , Persona de Mediana Edad , Nociceptores/fisiopatología , Dimensión del Dolor , Umbral del Dolor/fisiología , Estudios Prospectivos , Resultado del Tratamiento , Ganglio del Trigémino/fisiopatología , Nervio Trigémino/fisiopatología , Neuralgia del Trigémino/fisiopatologíaRESUMEN
Intrathecal drug delivery (IDD) is a proven and effective treatment alternative in carefully selected patients with chronic pain that cannot be controlled by a well-tailored drug regime and/or spinal cord stimulation (SCS), and may be specifically trialed in patients who fail to respond to SCS. While the lack of randomized controlled trials is often perceived as a limitation of IDD, many studies attest to the efficacy of this therapy, and a number are large-scale and with follow-up periods of up to five years. Good to excellent pain relief is achieved in many patients who have failed more conservative therapies, and there is often a reduced need for analgesia. The advent of patient-controlled analgesia allows flexibility of dosing according to the patient's needs. Consequently, quality of life improves in many patients and the majority express satisfaction with treatment. Some patients are able to return to work. The benefits of IDD (including a potent analgesic response with a more stable therapeutic drug level, decreased latency, increased duration of action, and decreased pharmacological complications) mean that side effects such as nausea, vomiting, sedation, and constipation are reduced. In addition, IDD demonstrates long-term cost-effectiveness when compared to conventional pain therapies, addressing a concern that affects many physicians in clinical practice today.
Asunto(s)
Analgésicos/administración & dosificación , Sistemas de Liberación de Medicamentos/tendencias , Dolor Intratable/tratamiento farmacológico , Enfermedades del Sistema Nervioso Periférico/tratamiento farmacológico , Analgésicos/efectos adversos , Analgésicos/farmacocinética , Análisis Costo-Beneficio/estadística & datos numéricos , Sistemas de Liberación de Medicamentos/métodos , Sistemas de Liberación de Medicamentos/normas , Humanos , Inyecciones Espinales/métodos , Inyecciones Espinales/normas , Dolor Intratable/fisiopatología , Satisfacción del Paciente , Enfermedades del Sistema Nervioso Periférico/fisiopatología , Autoadministración/normas , Espacio Subaracnoideo/efectos de los fármacos , Espacio Subaracnoideo/fisiología , Resultado del TratamientoRESUMEN
Low-back pain is one of the most common causes for seeking professional medical assistance and the most frequent cause of absence from work. It is not rare that the intervertebral discs are the etiological factor. Degenerated discs with internal disruptions may cause axial back pain whereas protrusion or herniation of a disc may result in radicular pain. Open surgical procedures targeting the intervertebral discs are carried out frequently for years. But especially because of its lack of superiority over the conventional therapies in the long-term and the risk of development of failed back surgery syndrome, the investigators are forced to develop minimally invasive techniques of disc decompression. In the last two decades, better understanding of the spinal anatomy, function and pain generating mechanisms along with the technological achievements, has accelerated the development of many modalities for the treatment of low back pain. Chemonucleolysis, automated percutaneous lumbar discectomy (APLD), intradiscal laser discectomy, intradiscal electrothermal therapy (IDET) and most recently percutaneous nucleoplasty are the minimally invasive techniques developed for this aim. Percutaneous nucleoplasty is a minimally invasive technique which uses radiofrequency energy to ablate the nucleus pulposus in a controlled manner for disc decompression. The current data about this new technique is insufficient yet, but the preliminary reports indicate that the technique is relatively safe and the outcomes are encouraging.
Asunto(s)
Discectomía Percutánea/métodos , Desplazamiento del Disco Intervertebral/cirugía , Vértebras Lumbares/cirugía , Humanos , Procedimientos Quirúrgicos Mínimamente Invasivos/métodosRESUMEN
Lesioning using radiofrequency (RF) current has been increasingly used in clinical practice for the treatment of pain syndromes. Although formation of heat causing "thermocoagulation" of the nervous tissues is thought to be responsible of the clinical outcome, a more recent modality of RF application named pulsed radiofrequency (PRF) delivers the RF current without producing destructive levels of heat. In our study, we compared the effects of conventional RF (CRF) and PRF on rabbit dorsal root ganglion (DRG) morphology, including also control and sham operated groups. The setting of the experiment and the RF parameters used were similar to those used in current clinical practice. The specimens were analyzed both with light microscopy and electron microscopy, two weeks after the procedure. At the light microscopic level, all groups had preserved the normal DRG morphology and no differences were observed between them. In the electron microscopic analysis there were no pathological findings in the control and sham operated groups. But the ganglion cells in the RF groups had enlarged endoplasmic reticulum cisterns and increased number of cytoplasmic vacuoles which were more evident in the CRF group. Some of the ganglion cells in the CRF group had mitochondrial degeneration, nuclear membrane disorders or loss of nuclear membrane and neurolemma integrity. The myelinated and unmyelinated nerve fibers were of normal morphology in all groups. Our results suggest that PRF application is less destructive of cellular morphology than CRF at clinically used "doses". Before making certain judgements, more experimental and clinical studies should be planned.
Asunto(s)
Ablación por Catéter/métodos , Ganglios Espinales/efectos de la radiación , Fibras Nerviosas/efectos de la radiación , Animales , Ganglios Espinales/ultraestructura , Vértebras Lumbares , Microscopía Electrónica de Transmisión , Fibras Nerviosas/ultraestructura , ConejosRESUMEN
The percutaneus blockade of the celiac plexus is being performed nearly for a century. The aim of performing celiac plexus and splancnic nerve blocks was surgical anesthesia at the beginning. But because of the technical demands and variable results of celiac plexus and splanchnic nerve blocks as a surgical anesthetic, over time, these techniques were supplanted by spinal anesthesia and segmental blockade of the somatic paravertebral nerves. As celiac plexus and splanchnic nerve blocks were falling into disuse for surgical anesthesia, the clinical utility of these techniques was becoming apparent in the new specialty of pain management. Celiac plexus and splancnic nerve blocks are effective in relieving chronic abdominal pain, especially originating from the malignancies of the pancreas, liver, gallbladder, omentum, mesentery, and alimentary tract from the stomach to the transverse portion of the large colon. The relevant anatomy, indications, cotraindications, different application techniques and results of celiac blockade is reviewed in this paper.
Asunto(s)
Dolor Abdominal/terapia , Bloqueo Nervioso Autónomo/métodos , Plexo Celíaco , Dolor Intratable/terapia , Nervios Esplácnicos , HumanosRESUMEN
Besides the causes and prevention issues, chronic nonmalignant pain must be considered as a combination of multidimensional disorder of neurophysiology, behavior, culture, social, economic aspects.
RESUMEN
Palliative treatment, pain therapy and quality of life (QOL) are very important in pancreatic cancer patients. We evaluated the pain relieving efficacy, side effects and effects on QOL of neurolytic coeliac plexus blockade (NCPB) and splanchnic nerves neurolytic blockade (SNB) in body and tail located pancreatic cancer. The study protocol was approved by the local ethics committee. Patients were randomly divided into two groups. Coeliac group; GC, N = 19 were treated with coeliac plexus blockade, whereas the patients in splanchnic group; GS, N = 20 were treated with bilateral splanchnic nerve blockade. The VAS values, opioid consumption and QOL (Patient satisfaction scale=PSS, performance status scale=PS) were evaluated prior to the procedure and at 2 weeks intervals after the procedure with the survival rates. The demographic features were found to be similar. The VAS differences (difference of every control's value with baseline value) in GS were significantly higher than the VAS differences in GC on every control meaning that VAS values in GS decreased more than the VAS values in GC. GS patients were found to decrease the opioid consumption significantly more than GC till the 6th control. GS patients had significant improvement in PS values at the first control. The mean survival rate was found to be significantly lower in GC. Two patients had severe pain during injection in GC and 5 patients had intractable diarrhoea in GC. Comparing the ease, pain relieving efficacy, QOL-effects of the methods, splanchnic nerve blocks may be an alternative to coeliac plexus blockade in patients with advanced body and tail located pancreatic cancer.
Asunto(s)
Plexo Celíaco , Bloqueo Nervioso , Dolor Intratable/etiología , Dolor Intratable/terapia , Neoplasias Pancreáticas/complicaciones , Nervios Esplácnicos , Adulto , Anciano , Analgésicos Opioides/administración & dosificación , Analgésicos Opioides/uso terapéutico , Anestésicos Locales , Codeína/administración & dosificación , Codeína/uso terapéutico , Femenino , Humanos , Lidocaína , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Dolor Intratable/psicología , Estudios Prospectivos , Calidad de Vida , Método Simple Ciego , Análisis de SupervivenciaRESUMEN
In this study, we have evaluated clinical results of the discTRODE system, in 15 patients with discogenic pain. All procedures were performed under sterile conditions with fluoroscopic guidance. After identifying the disc space under fluoroscopy, the introducer of the discTRODE was introduced using a tunneled vision. After inserting the introducer; navigable, semi-rigid discTRODE catheter was advanced through the introducer and directed medially and contralaterally along the posterior nuclear-annular interface. The SMK Thermocouple Electrode was placed in the outer-annulus on the contralateral side so as to monitor local tissue temperature. The treatment temperature was manually increased in a step-wise progression from 50 degrees C to 65 degrees C. Patient outcomes were evaluated during follow-up visits at 1, 3, 6 and 12th months post-procedure. Before the procedure and at each visit during the follow-up period, patients completed Visual Analogue Pain Scale (VAS) and Short Form-36 Health Status Questionnaire (SF-36). Annuloplasty was performed without difficulty in all patients, there were no complications associated with disc puncture such as discitis or disc rupture. Symptoms improved in 10 of 15 (66.6 %) of the patients on the SF-36 Physical Function subscale, in 9 of 15 (60 %) on the SF-36 Bodily Pain subscale and in 9 of 15 (60 %) on the VAS scores. 5 of 15 of the patients did not show improvement on any scale. This technique seems to be a reliable method for patients complaining of discogenic pain. However, prospective randomized controlled studies comparing different approaches are needed.
Asunto(s)
Electrocirugia/métodos , Desplazamiento del Disco Intervertebral/cirugía , Dolor de la Región Lumbar/cirugía , Adulto , Femenino , Estudios de Seguimiento , Calor , Humanos , Desplazamiento del Disco Intervertebral/patología , Dolor de la Región Lumbar/patología , Masculino , Registros Médicos , Persona de Mediana Edad , Dimensión del Dolor , Estudios Retrospectivos , Encuestas y Cuestionarios , Resultado del TratamientoRESUMEN
Myofascial pain syndrome is a painful musculoskeletal condition, and a quite common cause of chronic pain. It is characterized by the development of trigger points that are locally tender when active, and refer pain through specific patterns to other areas of the body. Its etiological factors are various; trauma, vertebral column diseases, systemic disorders, psychological distress, lack of motion, and chilling of the body parts. Myofascial pain syndrome may be misdiagnosed as arising from a visceral source especially if its probability is not kept in mind and a proper patient examination is lacking. Although there are many therapeutic approaches, trigger point injections can be diagnostic and therapeutic.
Asunto(s)
Síndromes del Dolor Miofascial/diagnóstico , Dolor Abdominal/diagnóstico , Dolor Abdominal/tratamiento farmacológico , Dolor Abdominal/patología , Anciano , Enfermedad Crónica , Diagnóstico Diferencial , Femenino , Humanos , Inyecciones , Síndromes del Dolor Miofascial/tratamiento farmacológico , Síndromes del Dolor Miofascial/patología , Dimensión del DolorRESUMEN
BACKGROUND AND OBJECTIVES: In this study, we have performed hypogastric plexus block using a posterior transdiscal approach in 20 patients diagnosed with pelvic pain because of cancer. METHODS: The L(5)-S(1) interdiscal space was identified with fluoroscopy. A needle attached to a 5-mL syringe was introduced through the disc and advanced under lateral fluoroscopic control until resistance was lost. After verifying proper position, 5 mL of 10% aqueous phenol was administered through the needle. After drawing back the needle, cephazolin 50 mg in 1 mL was administered to the disc to prevent discitis. The visual analog scale (VAS) values, daily analgesic requirements, and patient satisfaction were evaluated before the procedure, at 24 hours and then every month for 3 months after the procedure. RESULTS: Disc puncture was performed without difficulty in all patients, there were no complications associated with disc puncture such as discitis or disc rupture. Twelve patients had statistically significant pain relief immediately after the block (P <.05). Fifteen patients were satisfied after the block, and their daily analgesic requirement decreased significantly. No pain relief was observed in 5 patients. CONCLUSIONS: Transdiscal approach to the hypogastric plexus appears to be a safe and effective procedure. However, prospective randomized controlled studies comparing different approaches are needed to increase our knowledge of hypogastric plexus block.