RESUMEN
Chronic sleep deprivation is increasingly common in industrialized societies. Short sleep duration has been associated with a number of negative health outcomes. The objectives of this study were to investigate the association between self-reported sleep duration and the presence of metabolic syndrome (combination of central obesity, triglyceride, high density lipoprotein, blood pressure, fasting plasma glucose) in adults during midlife. The Korean Genomic Rural Cohort (KGRC) is a cohort study of aged 40 to 70 years in rural Korea. This study focuses on the prevalence, incidence, and risk factors for chronic degenerative disorders, such as hypertension, diabetes, osteoporosis, respiratory diseases, and metabolic syndrome. The baseline sample of participants in the KGRC study was recruited in 2005-2006 (phase 1). Respondents were followed until 2008-2009 (phase 2). The final sample included 1,107 subjects: 386 males (34.9%) and 721 females (65.1%). The incidence rate of metabolic syndrome in our sample was 18.4% (21.2% for males and 16.9% for females). Subjects sleeping < 6 hours a day (HR: 1.798; 95% CI: 1.06-3.05) were significantly more likely to experience metabolic syndrome than participants sleeping 6 to 7.9 hours a day after controlling for potential covariates (age, body mass index, menopause, smoking, alcohol and physical activity). Shorter sleep duration was associated with the high incidence of metabolic syndrome among females only. In conclusion, shorter sleep duration may be a significant risk factor for the development of metabolic syndrome in women.
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Síndrome Metabólico/epidemiología , Síndrome Metabólico/fisiopatología , Sueño/fisiología , Adulto , Anciano , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Masculino , Persona de Mediana Edad , República de Corea/epidemiología , Factores de TiempoRESUMEN
BACKGROUND: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). METHODS: This study included 1532 men and 1856 women, aged 40-70 y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. RESULTS: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p<0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). CONCLUSIONS: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.
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Adiponectina/sangre , Resistencia a la Insulina , Leptina/sangre , Síndrome Metabólico/sangre , Adulto , Anciano , Femenino , Homeostasis , Humanos , Masculino , Persona de Mediana Edad , República de CoreaRESUMEN
BACKGROUND AND AIMS: Metabolic syndrome (MetS) is considered to be an insulin-resistance syndrome, but recent evidence suggests that MetS has multiple physiological origins which may be related to atherosclerosis. This study investigated clustering patterns of metabolic risk factors and its association with sub-clinical atherosclerosis. SUBJECTS AND METHODS: This study used factor analysis of 11 metabolic factors in 1374 individuals to define clustering patterns and determine their association with carotid intima-media thickness (CIMT). Eleven metabolic factors were used: body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), fasting blood insulin (FBI), serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), homeostasis model assessment-insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hsCRP) and adiponectin. Two regression analyses were done, the first using individual metabolic variables and the second using each factor from the factor analysis to evaluate their relationships with CIMT. RESULTS: Four clustering patterns, insulin-resistance factor (FBG, FBI, HOMA-IR), obesity-inflammatory factor (BMI, WC, hsCRP), blood pressure factor (SBP, DBP) and lipid metabolic factor (HDL-C, TG, adiponectin) were categorized. In a multivariate regression model after adjustment for age, sex, low-density lipoprotein cholesterol and smoking history (pack year), insulin resistance factor (B = 11.09, p = 0.026), obesity-inflammatory factor (B = 18.50, p < 0.001), blood pressure factor (B = 12.84, p = 0.010) and lipid metabolic factor (B = - 11.55, p = 0.023) were found to be significantly associated with CIMT. CONCLUSION: In conclusion, metabolic risk factors have four distinct clustering patterns that are independently associated with sub-clinical atherosclerosis.
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Pueblo Asiatico , Aterosclerosis/complicaciones , Aterosclerosis/epidemiología , Síndrome Metabólico/complicaciones , Síndrome Metabólico/epidemiología , Análisis por Conglomerados , Estudios de Cohortes , Análisis Factorial , Femenino , Humanos , Modelos Lineales , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , República de Corea/epidemiología , Factores de Riesgo , Túnica Íntima/patología , Túnica Media/patologíaRESUMEN
UNLABELLED: Abstract Background: Chronic inflammation and oxidative stress are associated with the development of metabolic syndrome (MetS). Bilirubin is an antioxidant and has a protective effect against cardiovascular disease (CVD). The purpose of this study was to examine the association between total bilirubin levels and the prevalence of MetS in rural Korean women. METHODS: This cross-sectional study included 5,266 women (>40 years) enrolled in the Korean Genomic Rural Cohort (KGRC). MetS was defined using the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) guidelines. Total bilirubin levels were categorized into quartiles. RESULTS: Subjects in the upper quartiles of total bilirubin were younger and had lower waist circumferences, systolic blood pressure, and triglyceride levels and higher high-density lipoprotein cholesterol (HDL-C) concentrations. The overall prevalence of MetS was 39.0%. When the participants were categorized into quartiles by total bilirubin level, the prevalence of MetS according to increasing total bilirubin quartiles was 47.9%, 41.2%, 34.3%, and 32.7%, respectively. By comparison to the lowest quartile of total bilirubin (<0.61 mg/dL), the odds ratio (OR) (95% confidence interval [CI]) for MetS in the highest quartile of total bilirubin (≥0.94 mg/dL) was 0.63 (0.52-0.77) after adjusting for menopausal status, C-reactive protein (CRP) levels, insulin resistance, and other covariates. CONCLUSIONS: Total bilirubin level appears to be inversely associated with the prevalence of MetS in rural Korean women >40 years of age in the KGRC, even after adjusting for risk factors of MetS, including body mass index (BMI), menopausal status, CRP levels, and homeostasis model assessment of insulin resistance (HOMA-IR).
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Bilirrubina/sangre , Síndrome Metabólico/sangre , Síndrome Metabólico/epidemiología , Adulto , Anciano , Análisis de Varianza , Estudios de Cohortes , Femenino , Humanos , Persona de Mediana Edad , República de Corea/epidemiología , Factores de Riesgo , Población RuralRESUMEN
PURPOSE/OBJECTIVES: To determine the feasibility of conducting a study of a tai chi self-help education program in Korean adults with gastric cancer and to describe the effects of a six-month tai chi self-help education program on depression, health-related quality of life (HRQOL), and immune markers. DESIGN: One-group, pre- and post-test design. SETTING: Outpatient clinics of two large hospitals in the Republic of Korea. SAMPLE: Convenience sample of 33 Korean adults with gastric cancer diagnoses after gastrectomy. METHODS: The Korean gastric cancer survivors participated in a 24-week tai chi self-help education program. The participants completed the Center for Epidemiologic Studies-Depression (Korean version) and the Functional Assessment of Cancer Therapy-General (Korean version) for HRQOL and provided blood samples for immune markers. All measurements were conducted at baseline and at one week following the 24-week intervention. MAIN RESEARCH VARIABLES: Feasibility was determined as the percentage of participants completing the 24-week protocol. Preliminary data on depression, HRQOL, and immune markers were obtained. FINDINGS: The dropout rate was 36.4%; 21 of 33 survivors participated in the tai chi self-help education program for 24 weeks. No complications or injuries occurred to the participants during the program. No significant differences were noted in depression, HRQOL, and immune markers before and after the intervention. CONCLUSIONS: Tai chi exercise, in combination with a self-help program, can be safe and feasible for Korean gastric cancer survivors. This feasibility study did not show that the tai chi self-help education program improves depression, HRQOL, and immune markers in Korean gastric cancer survivors. IMPLICATIONS FOR NURSING: Additional studies are needed to determine the long-term impact relative to usual care.
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Educación del Paciente como Asunto/organización & administración , Autocuidado , Neoplasias Gástricas/rehabilitación , Sobrevivientes , Taichi Chuan , Biomarcadores/sangre , Antígenos CD4/sangre , Relación CD4-CD8 , Antígenos CD8/sangre , Depresión/diagnóstico , Depresión/prevención & control , Depresión/psicología , Estudios de Factibilidad , Gastrectomía/psicología , Gastrectomía/rehabilitación , Humanos , Interleucina-6/sangre , Células Asesinas Naturales/metabolismo , Corea (Geográfico) , Investigación en Evaluación de Enfermería , Proyectos Piloto , Evaluación de Programas y Proyectos de Salud , Calidad de Vida/psicología , Autocuidado/métodos , Autocuidado/psicología , Neoplasias Gástricas/sangre , Neoplasias Gástricas/inmunología , Neoplasias Gástricas/psicología , Sobrevivientes/psicología , Taichi Chuan/organización & administración , Taichi Chuan/psicología , Factor de Necrosis Tumoral alfa/sangreRESUMEN
PURPOSE: The purpose of this study was to identify the factors influencing quality of life after analyzing the relationship between depression, health promotion and quality of life in patients with gastrointestinal neoplasms. METHODS: The subjects of this study were 63 people who underwent treatments from 2 general hospitals in Seoul and Daejeon and had no recurrence in stages I & II of gastrointestinal neoplasms. Data was collected from March 1 to April 30, 2006. A questionnaire consisting of Center for Epidemiologic Studies Depression (CES-D), Health Promoting Lifestyle Profile II (HPLP II) and Functional Assessment of Cancer Therapy-Colorectal (FACT-C) was given. The collected data was analyzed with the SPSS program which was used for descriptive statistics, Pearson correlation coefficients and hierarchical multiple regression. RESULTS: The major findings of this study were as follows: 1) There was a significant relationship between depression (r=-.639, p=.000), health promotion (r=.407, p=.001) and quality of life. 2) Significant factors were depression (F=-4.091, p=.000) and health promotion (F=2.375, p=.021) that explained 46% of quality of life (F=10.022, p=.000). CONCLUSION: Cancer patients experienced extreme depression which led to a negative effect on quality of life. Health promotion was an important variable to the quality of life and it gave the patients motivation for having a will and belief for better health.