RESUMEN
OBJECTIVES: According to the trauma hypothesis, women with fibromyalgia syndrome (FMS) are more likely to report a history of sexual and/or physical abuse than women without FMS. In this study, we rely on a community sample to test this hypothesis and the related prediction that women with FMS are more likely to have posttraumatic stress disorder than women without FMS. METHODS: Eligibility for the present study was limited to an existing community sample in which FMS and major depressive disorder were prevalent. The unique composition of the original sample allowed us to recruit women with and without FMS from the community. A total of 52 female participants were enrolled in the present FMS group and 53 in the control (no FMS) group. Sexual and physical abuse were assessed retrospectively using a standardized telephone interview. RESULTS: Except for rape, sexual and physical abuse were reported equally often by women in the FMS and control groups. Women who reported rape were 3.1 times more likely to have FMS than women who did not report rape (P<0.05). There was no evidence of increased childhood abuse in the FMS group. Women with FMS were more likely to have posttraumatic stress disorder symptoms (intrusive thoughts and arousal) as well as posttraumatic stress disorder diagnosis (P<0.01). DISCUSSION: With the exception of rape, no self-reported sexual or physical abuse event was associated with FMS in this community sample. In accord with the trauma hypothesis, however, posttraumatic stress disorder was more prevalent in the FMS group. Chronic stress in the form of posttraumatic stress disorder but not major depressive disorder may mediate the relationship between rape and FMS.
Asunto(s)
Violencia Doméstica/estadística & datos numéricos , Fibromialgia/epidemiología , Medición de Riesgo/métodos , Delitos Sexuales/estadística & datos numéricos , Trastornos por Estrés Postraumático/epidemiología , Adulto , Causalidad , Comorbilidad , Femenino , Humanos , New Jersey/epidemiología , Prevalencia , Factores de Riesgo , SíndromeRESUMEN
To assess the severity of substance use, abuse and dependence in a community sample of high school students, a cross-sectional survey was conducted in a suburban New Jersey community. Participants, a sample of 9th to 12th graders from six high schools (N=1044), completed a self-administered questionnaire after obtaining active parental consent. The measure of substance use disorders was based on 27 specially designed questions that approximate the DSM-IV criteria for abuse and dependence. Equivalent multivariate logit models were used to estimate the significant correlates for both use and dependence/abuse. The prevalence of drug use in this sample was similar to the national average for all drugs except alcohol. A total of 16.4% of the surveyed students reported either abuse or dependence symptoms with alcohol in the past year. The rates of abuse/dependence for marijuana and other illicit drugs were 13.4% and 3.9%. The rate of nicotine dependence was 8.0%. The logit models designed to examine the correlates of substance use showed minimal predictive or correlative value in explaining substance abuse or dependence in adolescence. More research is needed to identify and understand the factors leading adolescents from drug use to abuse or dependence.
Asunto(s)
Estudiantes , Trastornos Relacionados con Sustancias/epidemiología , Adolescente , Adulto , Estudios Transversales , Femenino , Humanos , Modelos Logísticos , Masculino , New Jersey/epidemiología , Prevalencia , Escalas de Valoración Psiquiátrica , Estudiantes/psicología , Salud UrbanaRESUMEN
OBJECTIVE: To examine the effectiveness of external qigong on the in vivo growth of transplantable murine lymphoma cells in mice. BACKGROUND: Qigong is a traditional Chinese health practice that is believed by many to have special preventive and healing power. Underlying the system is the belief in the existence of a subtle energy (qi), which circulates throughout the body, and when strengthened or balanced, can improve health and ward off or slow the progress of disease. To date, much of the literature showing the effects of qi are presented in the non-Western literature, and as such are viewed with considerable skepticism. In an attempt to demonstrate qi in a controlled setting, the effect of external qigong emission from a qigong healer on the in vivo growth of transplantable murine lymphoma cells in mice was explored in two pilot studies. METHODS: In study 1, 30 SJL/J mice were injected intravenously with lymphoma cells that localize and exhibit aggressive growth in the lymphoid tissues of untreated syngeneic recipients. These tumor-injected mice were divided into 3 groups: (1). qigong treatment (administered by a qigong healer); (2). sham treatment; and (3). no-treatment control. The sham group received the same number of treatments from a person without training in qigong, who imitated the motions of the qigong healer. The control group received no treatment at all. In study 1, the mice were sacrificed on the 9th or 11th days after tumor-cell injection, and in study 2, the mice were sacrificed on the 10th and 13th days. Tumor growth in lymph nodes (LN) was estimated by LN weight expressed as a percentage of total body weight. RESULTS: In study 1, LNs from mice in the qigong-treated group were significantly smaller than LN from mice in either the control group or in the sham treatment group (p < 0.05), suggesting that there was less tumor growth in the qigong-treated mice. In study 2, using the same design as study 1, the same pattern of difference found in study 1 emerged: LN ratio from mice in the qigong-treated group was smaller than that in either the control group or in the sham group. However, these results did not reach statistical significance, partially as a result of larger variances in all groups in this study. CONCLUSIONS: These preliminary results, while still inconclusive, suggest that qigong treatment from one particular qigong practitioner might influence the growth of lymphoma cells negatively. Further studies with different practitioners, more repeated trials, and/or different tumor models are needed to further investigate the effects of external qigong on tumor growth in mice.