RESUMEN
Three new oxygenated ergostanoids, 1-3, one known ergostanoid, 4, one new trinoreudesmadienone, 5, one new calamenene type sesquiterpene, 6, and one known aristolane-type sesquiterpene, (-)-aristolone (7), have been isolated from the AcOEt extract of the soft coral Nephthea erecta. The structures of these compounds were determined by extensive spectroscopic and X-ray crystallographic analysis, as well as Mosher's method. We revised the absolute configuration at C(23) in the side chain of some lanostanoids as a result of the Mosher's products of 1 (i.e., 1a and 1b). The cytotoxicities against selected cancer cells and the anti-inflammatory effects of these tested metabolites 1-7 were determined in vitro.
Asunto(s)
Antozoos/química , Lanosterol/análogos & derivados , Animales , Línea Celular , Humanos , Lanosterol/química , Lanosterol/aislamiento & purificación , Lanosterol/farmacología , Espectroscopía de Resonancia Magnética , RatonesRESUMEN
Eleven new xenia diterpenoids, umbellacins A-G (1-7), 14,15-epoxy-xeniolide H (8), 3-acetyl-14,15-epoxy-xeniolide H (9), and umbellacins H and I (10, 11), were isolated from a methylene chloride-soluble fraction of the soft coral Xenia umbellata. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Asunto(s)
Antozoos/química , Antineoplásicos/aislamiento & purificación , Diterpenos/aislamiento & purificación , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Diterpenos/química , Diterpenos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Taiwán , Células Tumorales CultivadasRESUMEN
Eight new nornardosinane sequiterpenoids, laevinols A-H (1-8), a new neolemnane sesquiterpenoid, laevinone A (9), and the previously known 6beta-acetyl-4beta,5beta-dimethyl-1(10)alpha-epoxy-2beta-hydroxy-7-oxodecalin (10) and 11,12-dihydroxy-6,10-eremophiladiene (11) were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia laevis. Their structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Asunto(s)
Antozoos/química , Antineoplásicos/aislamiento & purificación , Sesquiterpenos/aislamiento & purificación , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Leucemia P388 , Ratones , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Sesquiterpenos/química , Sesquiterpenos/farmacología , Taiwán , Células Tumorales CultivadasRESUMEN
Eight new xenia diterpenoids, blumiolide-A (1) (novel carbon skeleton), blumiolide-B (2), 9-deoxy-isoxeniolide-A (3), 9-deoxy-7,8-epoxy-isoxeniolide-A (4), 9-deacetoxy-7,8-epoxy-13-epi-xenicin (5), 9-deoxy-7,8-epoxy-xeniolide-A (6), blumiolide-C (7), and blumicin-A (8), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia blumi. Their structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Asunto(s)
Antozoos/química , Antineoplásicos/aislamiento & purificación , Diterpenos/aislamiento & purificación , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Diterpenos/química , Diterpenos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Leucemia P388 , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Taiwán , Células Tumorales CultivadasRESUMEN
Xenibellols A (1) and B (2), possessing an unprecedented diterpenoid skeleton, were isolated from the soft coral Xenia umbellata. The structures of xenibellols A and B were established by extensive analysis of spectroscopic data.
Asunto(s)
Antozoos/química , Antineoplásicos/aislamiento & purificación , Diterpenos/aislamiento & purificación , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Diterpenos/química , Diterpenos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Leucemia P388 , Estructura Molecular , TaiwánRESUMEN
Ten new prenylbicyclogermacrane diterpenoids, pacificins A-J (1-10), were isolated from the methylene chloride solubles of the Formosan soft coral Nephthea pacifica. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Asunto(s)
Antozoos/química , Antineoplásicos/aislamiento & purificación , Diterpenos/aislamiento & purificación , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Diterpenos/química , Diterpenos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Leucemia P388 , Ratones , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , TaiwánRESUMEN
One new cytotoxic steroid, dendronesterone A (1), two new steroids, dendronesterones B and C (2 and 3), and a known steroid (4) were isolated from the methylene chloride solubles of the Formosan soft coral Dendronephthya gigantea. Two cytotoxic ylangene-type sesquiterpenoids, lemnalol (5) and the new compound cervicol (6), as well as two ylangene-type sesquiterpenoids, isolemnalol (7) (a new compound) and 4-oxo-alpha-ylangene (8), were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia cervicorni. Their structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Asunto(s)
Antozoos/química , Antineoplásicos/aislamiento & purificación , Sesquiterpenos/aislamiento & purificación , Esteroides/aislamiento & purificación , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Células HT29 , Humanos , Leucemia P388 , Ratones , Ratones Endogámicos DBA , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Océanos y Mares , Sesquiterpenos/química , Sesquiterpenos/farmacología , Esteroides/química , Esteroides/farmacología , Células Tumorales CultivadasRESUMEN
Five new nardosinane sesquiterpenoids, armatins A-E, lemnal-1(10)-ene-2,12-dione (a new natural product), and two new cytotoxic 19-oxygenated ergosterols, armatinols A and B, were isolated from the methylene chloride extract of the soft coral Nephthea armata, collected in Taiwan. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity was determined against selected cancer cells.
Asunto(s)
Antozoos/química , Antineoplásicos/aislamiento & purificación , Ergosterol/análogos & derivados , Ergosterol/aislamiento & purificación , Sesquiterpenos/aislamiento & purificación , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Ergosterol/química , Ergosterol/farmacología , Humanos , Leucemia P388 , Ratones , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Sesquiterpenos/química , Sesquiterpenos/farmacología , Estereoisomerismo , Taiwán , Células Tumorales CultivadasRESUMEN
Eight new vibsane-type diterpenoids, vibsanins P-W (1-8), were isolated from the methanol extracts of the leaves and twigs of Viburnum awabuki. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Diterpenos/aislamiento & purificación , Plantas Medicinales/química , Viburnum/química , Animales , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Diterpenos/química , Diterpenos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Leucemia P388 , Ratones , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Hojas de la Planta/química , Taiwán , Células Tumorales CultivadasRESUMEN
Four tetracyclic triterpenoids and lupeol were isolated from the hybrid Parthenium argentatum x P. tomentosa. The new triterpenoids were identified as 16, 24-epoxy-3 alpha-hydroxylanost-8-ene (argentatin E); 16, 24-epoxy-25-hydroxycycloart-1, 11, 22-trien-3-one (argentatin F); 16,24-dihydroxycycloart-20, 25-dien-3-one (argentatin G) and 16, 24-dihydroxycycloart-25-en-3-one (argentatin H). The chemical identities of these compounds were confirmed by the different spectrometric measurements.