RESUMEN

Efficient and general procedures have been developed for the solution-phase preparation of substituted morpholine derivatives, and a library has been produced around generic structure 1. This library was designed with proprietary modeling software for use as a general screening library. The 30 R1 reagents were phenols, and the 275 R2 reagents were taken from five different reagent classes, giving a variety of product classes in the final library of 8250 potential products. All of the library members were generated from a common intermediate, mesylate (5), which was synthesized efficiently, in bulk, in three steps from N-benzylethanolamine (2). High-throughput chemistry using robotics was carried out to produce the 7907 library members, which were individually characterized by reversed-phase LC/MS analysis.

Asunto(s)

Técnicas Químicas Combinatorias/métodos , Morfolinas/síntesis química , Aldehídos/química , Ácidos Carboxílicos/química , Diseño de Fármacos , Cromatografía de Gases y Espectrometría de Masas , Isocianatos/química , Isotiocianatos/química , Espectroscopía de Resonancia Magnética , Morfolinas/química , Fenoles/química , Ácidos Sulfínicos/química