RESUMEN
One hundred and three patients with small cell lung carcinoma were stratified according to stage of disease (47 limited disease, 56 extensive disease) and then randomised to receive etoposide 300 mg/m2 alone for two days or a combination (VAC) of vincristine 1 mg/m2, doxorubicin (Adriamycin) 50 mg/m2, and cyclophosphamide 1000 mg/m2. The drugs were given at three week intervals. Patients were assessed after three cycles of treatment and continued with the same regimen if in complete remission and with the alternative regimen if in partial remission; they were withdrawn if the disease had progressed. Twenty four patients (23%) achieved complete remission and this occurred more often when patients were receiving VAC (19 of 82) than etoposide (5 of 75). There was no difference, however, in overall survival between those initially treated with etoposide and those having combination chemotherapy, whether for limited disease (both 8 months) or extensive disease (7 and 5.5 months). Toxicity was less with etoposide. Survival was disappointing, especially with limited disease, even in patients who showed a complete response to treatment.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Carcinoma de Células Pequeñas/tratamiento farmacológico , Etopósido/uso terapéutico , Neoplasias Pulmonares/tratamiento farmacológico , Análisis Actuarial , Adulto , Anciano , Carcinoma de Células Pequeñas/mortalidad , Ciclofosfamida/administración & dosificación , Doxorrubicina/administración & dosificación , Femenino , Humanos , Neoplasias Pulmonares/mortalidad , Masculino , Persona de Mediana Edad , Vincristina/administración & dosificaciónAsunto(s)
Mesotelioma/diagnóstico , Enfermedades Profesionales/diagnóstico , Neoplasias Pleurales/diagnóstico , Contaminantes Ocupacionales del Aire/efectos adversos , Amianto/efectos adversos , Humanos , Mesotelioma/etiología , Mesotelioma/terapia , Enfermedades Profesionales/etiología , Enfermedades Profesionales/terapia , Pleura/diagnóstico por imagen , Pleura/patología , Derrame Pleural/citología , Neoplasias Pleurales/etiología , Neoplasias Pleurales/terapia , RadiografíaAsunto(s)
Amianto/efectos adversos , Neoplasias Pulmonares/epidemiología , Enfermedades Profesionales/epidemiología , Enfermedades Pleurales/complicaciones , Navíos , Adulto , Anciano , Inglaterra , Métodos Epidemiológicos , Humanos , Neoplasias Pulmonares/etiología , Masculino , Persona de Mediana Edad , Riesgo , Fumar/complicacionesRESUMEN
Ffty cases of malignant pleural mesothelioma (47 men and 3 women) have been diagnosed during the period 1966-76 in Barrow-in-Furness, all of them histologically proved and accepted by the Pneumoconiosis Panel. At the time of writing only three survive. There was a history of industrial exposure to asbestos in all 47 men, who had worked in various trades in the shipyard, as had one of the women. One of the women was married to a shipyard plumber, who may have brought home asbestos dust on his clothes. Only one patient, a housewife, aged 28 at diagnosis, had no known asbestos contact. The asbestos content of the lungs has been measured in the last 20 cases, in 18 of whom it was found to be substantially greater than the accepted levels for the general population. In a small number studied by electron microscopy, the predominant fibre was crocidolite. A positive histological diagnosis was achieved in 39 subjects during life in the expectation of securing industrial compensation, but, in spite of this, less than half of the dependants are currently receiving payments. Metastases, though never clinically apparent, were frequent at necropsy.
Asunto(s)
Mesotelioma/diagnóstico , Neoplasias Pleurales/diagnóstico , Adulto , Anciano , Amianto/análisis , Asbestosis/complicaciones , Femenino , Humanos , Pulmón/análisis , Pulmón/patología , Masculino , Mesotelioma/etiología , Mesotelioma/patología , Persona de Mediana Edad , Metástasis de la Neoplasia , Enfermedades Profesionales/etiología , Neoplasias Pleurales/etiología , Neoplasias Pleurales/patología , NavíosAsunto(s)
Amianto/efectos adversos , Enfermedades Profesionales/inducido químicamente , Enfermedades Respiratorias/inducido químicamente , Neoplasias de los Bronquios/inducido químicamente , Neoplasias de los Bronquios/mortalidad , Inglaterra , Exposición a Riesgos Ambientales , Humanos , Mesotelioma/inducido químicamente , Mesotelioma/mortalidad , Neoplasias Pleurales/inducido químicamente , Neoplasias Pleurales/mortalidad , NavíosRESUMEN
The paper describes the Toxicology Data Bank, a new system under development that will provide on-line access to chemical, physical, toxicologic, pharmacologic, use, and manufacturing data on 4000-5000 selected chemicals including drugs.
Asunto(s)
Sistemas de Información , National Library of Medicine (U.S.) , Toxicología , Indización y Redacción de Resúmenes , Computadores , Presentación de Datos , Sistemas en Línea , Descriptores , Estados UnidosRESUMEN
A study of the prognostic value of serum fibrin/fibrinogen degradation products (FDP) in 137 consecutive patients with acute myocardial infarction showed a positive correlation between high FDP levels and poor prognosis. Both the frequency of complications and the mortality were related to increased levels of FDP, the highest of which were found between the fourth and eighth days after infarction.