1.
Org Lett
; 25(32): 6052-6056, 2023 Aug 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37560921
RESUMEN
A new methodology to afford α-amino nitriles through oxidative cyanomethylation of amines using nitromethane as the methylene source in the presence of Me3SiCN without the addition of an external oxidant was developed. A catalytic amount of AgCN and a stoichiometric amount of LiBF4 cooperatively promoted the transformation. A wide variety of the amines, including both aromatic compounds and aliphatic ones, which are labile under oxidative conditions, were applicable to the reaction.