RESUMEN

Alzheimer's disease (AD) is the most common form of dementia that occurs in the brain. This is a chronic neurodegenerative disease which is valid in 60-70% of all dementia patients. Boron, regarded as a potential antioxidant, has the effect of reducing oxidative stress. Taurine, as one of the thiol-containing amino acids, exists at different concentrations in both the neurons and glial cells of the central nervous system. It plays an important role in the protective and adjuvant therapies as an antioxidant due to its characteristics of maintaining the oxidant-antioxidant balance of the body as well as cell integrity and increasing body resistance. Based on this information, our objective was to reveal the effect of boron alone, taurine alone plus co-administration of taurine and boron application on brain tissue protein carbonyls (PC) and serum advanced oxidation protein products (AOPP) levels in the experimental Alzheimer's model. For this purpose, 5 groups were formed in our study which consisted of 30 Wistar albino male rats. The rats were given a single dose of STZ stereotaxically. At the end of this period, the rats were decapitated, plus their brain tissues and blood were removed. Our findings suggested that taurine alone and co-administration of boron and taurine had a decreasing effect on AOPP and PC levels of the experimental Alzheimer model of the rats.

Asunto(s)

Enfermedad de Alzheimer , Enfermedades Neurodegenerativas , Ratas , Animales , Antioxidantes/metabolismo , Taurina/farmacología , Productos Avanzados de Oxidación de Proteínas/metabolismo , Productos Avanzados de Oxidación de Proteínas/farmacología , Ratas Wistar , Boro/farmacología , Enfermedad de Alzheimer/tratamiento farmacológico , Enfermedad de Alzheimer/metabolismo , Carbonilación Proteica , Estrés Oxidativo

RESUMEN

Although 2,4-DNP is claimed to promote fast weight reduction, it is also related with an intolerable high risk of serious side effects to various tissues. On the other hand, it is known to have neuroprotective effects. These different effects of 2,4-DNP may be due to the administration conditions. For this reason, in this study, it was aimed for the first time to clarify the oxidative changes that occur in the brain during the use of 2,4-DNP, depending on the dose, time and gender. For this purpose, 60 Wistar rats (30 male, 30 female) were divided into ten groups: control groups, short-term/long-term groups and low dose/high dose groups. Except for the control groups, 2,4-DNP was administered to the other groups by oral gavage. End of the experiment, thiobarbituric acid-reactive substances (TBARs), glutathione (GSH), nitric oxide (NOx) and ascorbic acid (AA) levels were measured in the brain tissues of sacrificed animals. 2,4-DNP administration showed attenuation impact on oxidative stress depending on both dose, time and gender. It can be said that it is more beneficial in terms of neuroprotection, especially in the short-term and male groups. In conclusion, our findings suggest that, depending on the dose, time, and gender, 2,4-DNP may be beneficial in the treatment of neurodegenerative disorders.

Asunto(s)

2,4-Dinitrofenol , Estrés Oxidativo , Ratas , Animales , Masculino , Femenino , 2,4-Dinitrofenol/farmacología , Ratas Wistar , Factores Sexuales , Glutatión/metabolismo , Sustancias Reactivas al Ácido Tiobarbitúrico

RESUMEN

In this study, some shrinkage estimators using a median ranked set sample in the presence of multicollinearity were studied. Initially, we constructed the multiple regression model using median ranked set sampling. We also adapted the Ridge and Liu-type estimators to these multiple regression model. To investigate the efficiency of these estimators, a simulation study was performed for a different number of explanatory variables, sample sizes, correlation coefficients, and error variances in perfect and imperfect ranking cases. In addition, these estimators were compared with other estimators that are based on ranked set sample using simulation study. It is shown that when the collinearity is moderate, Ridge estimator using median ranked set sample performs better than other estimators and when the collinearity increases, Liu-type estimator using median ranked set sample gets better than all other estimators do. When the collinearity is smaller than 0.95, ridge estimator based on median ranked set sample is more efficient than Liu-type estimator based on same sample. However, this threshold increases as the sample size increases and the number of explanatory variables decreases. In addition, real data example is presented to illustrate how collinearity affects the estimators under median ranked set sampling and ranked set sampling.