RESUMEN
To characterize oral sites affected by radiation-induced oral mucositis (OM) and related clinical outcomes in oral cancer patients subjected to prophylactic photobiomodulation therapy (PBMT). This study included advanced oral squamous cell carcinoma (OSCC) patients treated with prophylactic PBMT for OM. The site distribution of OM, OM grading (CTCAE NCI, Version 4.0, 2010), OM-related pain (VAS), analgesic protocol (WHO Analgesic Ladder), and use of enteral nutrition were evaluated weekly during treatment. Data analysis was performed using descriptive statistics expressed as median values and percentages. A total of 145 OSCC patients were included. OM most frequently affected the lateral border of the tongue (44.1%), buccal mucosa (37.2%), and labial mucosa (33.8%). Keratinized oral mucosa sites, including the tongue dorsum (6.21%), retromolar trigone (8.3%), and hard palate (2.76%), were less frequently affected. Peak OM scores were observed at weeks 5, 6, and 7, with severe OM (NCI grades 3 and 4) rates of 11%, 20%, and 25%, respectively. The cumulative occurrence of severe OM was 23%, which developed as early as week 3 and as late as week 7. The highest mean value of OM-related pain (2.7) was observed at the sixth week, and 13.8% of the patients required feeding support. This study showed, compared with studies that did not provide PBMT, reduced severity of mucositis, reduced pain and analgesic use, and reduced tube feeding in patients treated with PBMT. OM involving keratinized and non-keratinized surfaces should be included in the prophylactic PBMT to reduce severe OM in future studies.
Asunto(s)
Carcinoma de Células Escamosas/radioterapia , Terapia por Luz de Baja Intensidad , Neoplasias de la Boca/radioterapia , Estomatitis/etiología , Adulto , Anciano , Anciano de 80 o más Años , Analgesia , Carcinoma de Células Escamosas/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Índice de Severidad de la EnfermedadRESUMEN
Over the last decades, several articles have corroborated the need of using mouthguards in sports activities, manufactured with ethylene vinyl acetate (EVA) as their main material. There are different mouthguards techniques used by dentists worldwide to prevent injuries. A technique has been developed to help athletes, especially the partially edentulous patients, who were not getting the proper protection. The mouthguard technique consists in making EVA fillings to improve the adjustment and esthetics of mouthguard used by athletes. It is the authors' conviction that the technique may prevent injuries in sports activities without impairing the athletes' safety and esthetics.