RESUMEN
It is shown that restoration of plasma volume in 3-day-old pigs 6-12 hours after a 33% blood loss is a part of fluid elimination from the body as it occurs due to transfer of interstitial and, probably, intracellular liquid into the circulation and is accompanied by activation of diuresis. Activation of this process is not participated neither by hydrocortisone nor ACTH. Vasopressin and aldosterone have a negative effect on intravasation of interstitial fluid.
Asunto(s)
Fluidoterapia/métodos , Hipovolemia/fisiopatología , Hipovolemia/terapia , Hormona Adrenocorticotrópica/sangre , Aldosterona/sangre , Animales , Animales Recién Nacidos , Diuresis , Hidrocortisona/sangre , Volumen Plasmático , Sodio/orina , Tasa de Supervivencia , Porcinos , Vasopresinas/sangreRESUMEN
We evaluated the efficiency of perfusion with olifen in preventing oxidative stress at the early stage of acute pancreatitis. Transaortic perfusion with olifen prevented clinical and biochemical symptoms of acute pancreatitis, attenuated oxidative stress, reduced peritoneal exudation, and restricts the area of pancreatic necrosis to 6% tissue.
Asunto(s)
Antioxidantes/farmacología , Pancreatitis Aguda Necrotizante/prevención & control , Éteres Fenílicos/farmacología , Amilasas/sangre , Animales , Gatos , Modelos Animales de Enfermedad , Ácido Láctico/sangre , Estrés Oxidativo , Pancreatitis Aguda Necrotizante/sangre , Pancreatitis Aguda Necrotizante/patologíaRESUMEN
It was established in experiments on narcotized adult cats and pigs of different age that postnatal mammal development is characterized by the presence of a period of the smallest resistance to massive blood loss (33% of circulating blood volume) when the ability for fast spontaneous restitution of plasma volume is already lost but the mechanism of increasing resistance of peripheral vessels to hypovolemia for support of perfusion pressure of adult mammal is still weak.
Asunto(s)
Adaptación Fisiológica , Envejecimiento/fisiología , Circulación Sanguínea/fisiología , Hipovolemia/fisiopatología , Animales , Gatos , Hemodinámica , Hemorragia/fisiopatología , Porcinos , Factores de TiempoAsunto(s)
Volumen Sanguíneo , Hemorragia , Factores de Edad , Animales , Animales Recién Nacidos , Gatos , Mamíferos , PorcinosRESUMEN
The experiments on 28 unconscious male cats revealed the antishock effect of thyroidin (0.15 g/kg, intraperitoneally) through the positive myocardial inotropic effect, which, in addition to enhanced total peripheral vascular resistance, caused elevated blood pressure (BP). The antishock effect of thyroidin was substantially enhanced after a single intravenous injection of lactin (50 U/kg), as expressed by the recovery of plasma volumes, cardiac output at the expense of cardiac systolic volumes, and elevated BP. Thyroidin may be used only as an ingredient of combined antishock therapy as it induces intensive of oxidative process, as evidenced by higher utilization co-efficient for oxygen and its uptake at the baseline levels in shock, and by short-term elevations of blood temperatures.
Asunto(s)
Hemodinámica/efectos de los fármacos , Lactosa/uso terapéutico , Oxígeno/metabolismo , Choque Hemorrágico/tratamiento farmacológico , Hormonas Tiroideas/uso terapéutico , Animales , Gatos , Choque Hemorrágico/metabolismo , Choque Hemorrágico/fisiopatologíaRESUMEN
Experiments on 52 unconscious male cats have established that intravenous administration of lactin in a dose of 50 U/kg 1.5 hrs after 30% blood loss causes intracellular fluid to move into the extracellular space, which is accompanied by restoration of the plasma volume up to 94% of the baseline value and by enhancement of diuresis without substantial changes in the tissue hydrostatic pressure and osmolar concentration of plasma. The simultaneous use of lactin and verospiron, (3 mg/kg, i.p.), unlike lactin alone, retained the restored plasma volume in survived animals in the first 24 hours of blood loss.
Asunto(s)
Lactosa/farmacología , Volumen Plasmático/efectos de los fármacos , Choque Hemorrágico/tratamiento farmacológico , Animales , Gatos , Masculino , Choque Hemorrágico/sangreRESUMEN
Experiments on 49 unconscious have established that a considerable decrease in hematocrit values from 47 to 36% within the first 4-5 hours after blood loss (20 ml/kg) is associated with less longevity (r = 0.74; p < 0.01) and progressive hypovolemia (r = 0.30; p < 0.05) by depoting blood. A decrease in hematocrit values from 47 to 40% at min 20 following blood loss is an unfavourable predictor (r = 0.64; p < 0.01). The animals' longevity after blood flow is directly proportional to the volume of blood (r = 0.56; p < 0.01) and inversely proportionally to the baseline hematocrit values (r = 0.34; p < 0.05).
Asunto(s)
Volumen Sanguíneo/fisiología , Hematócrito , Hemorragia/fisiopatología , Animales , GatosRESUMEN
The possibility of increasing the efficacy of restoration of the circulating blood volume (CBV) in shock was demonstrated in experiments on 33 anesthesized female cats. Intramuscular injection of lactin one hour before blood loss (2% of body mass) in a dose of 5 U/kg or its intravenous infusion 90 minutes after blood loss in a dose of 50 U/kg was attended by restoration of the plasma volume in 5 hours. The prospects of further research into improvement of the efficacy of CBV in shock through activation of the body's reserves are substantiated.
Asunto(s)
Volumen Sanguíneo/efectos de los fármacos , Choque/tratamiento farmacológico , Animales , Gatos , Femenino , Choque/fisiopatologíaRESUMEN
Microsphere shunting technique revealed the shunting effect of the blood flow mainly in the distal part of the hind-limb skin, less evident in other parts of the limbs and no such effect in skeletal muscles.