RESUMEN
It is shown that cardiotropic drug refracterin promotes recovery of cardiac contraction and relaxation, their coordination destroyed in cardiac failure (CF) caused by 10-day toxico-allergic myocarditis (TAM). Pumping capacity of the heart returns to normal after normalization of functional activity of three systems of cardiomyocyte responsible for contraction-relaxation: contractile proteins, energy supply and calcium transport. The key process is refracterin-related reestablishment of normal content and proportion of adenyl nucleotides and creatininephosphate and regulation role of phosphorylation and energy of metabolic processes in the cells and their interaction. Thus, refracterin effectiveness lies in its ability to interfere in intracellular metabolic processes in the myocardium, to reestablish normal homeostasis of the systems responsible for contraction-relaxation function and eventually to remove left ventricular cardiac dysfunction.
Asunto(s)
Acetildigoxinas/farmacología , Fármacos Cardiovasculares/farmacología , Grupo Citocromo c/farmacología , Insuficiencia Cardíaca/fisiopatología , Corazón/efectos de los fármacos , Contracción Miocárdica/efectos de los fármacos , Miocarditis/fisiopatología , Miocardio/ultraestructura , Oxifedrina/farmacología , Acetildigoxinas/uso terapéutico , Animales , Transporte Biológico/efectos de los fármacos , Calcio/metabolismo , Fármacos Cardiovasculares/uso terapéutico , Grupo Citocromo c/uso terapéutico , Combinación de Medicamentos , Evaluación Preclínica de Medicamentos , Corazón/fisiopatología , Insuficiencia Cardíaca/tratamiento farmacológico , Insuficiencia Cardíaca/etiología , Hemodinámica/efectos de los fármacos , Proteínas Musculares/efectos de los fármacos , Proteínas Musculares/fisiología , Contracción Miocárdica/fisiología , Miocarditis/complicaciones , Miocarditis/tratamiento farmacológico , Miocardio/metabolismo , Oxifedrina/uso terapéutico , Conejos , Factores de TiempoRESUMEN
Heart overloading due to pressure as a result of 8 periodic full aortic constriction in heart failure (HF) caused by 10-day toxic-allergic myocarditis (TAM) leads to deterioration of heart contractility (pump function). This is explained by additional decline in functional activity of all three systems of cardiomyocyte responsible for contraction-relaxation. In particular, by a sharp fall of ATP and CP content in the myocardium, a 400% decrease in myofibril power, 200% reduction in efficiency of contraction and marked deterioration of calcium transport. The resultant exhaustion of myocardial reserve brought 70% lethality among the animals. Under the above conditions coordination between the systolic and diastolic cardiac functions, correlation between myocardial functional activity and subcellular systems of cardiomyocyte are impaired. In pressure heart overloading refracterin initiates profound metabolic rearrangements improving metabolism, remodelling of the system of energy supply, reestablishment of systemic homeostasis, normalization of cardiomyocyte and cardiac reserves.