RESUMEN

The association of simian T-cell leukemia virus with baboons malignant lymphoma was studied. Proviral DNA integrated in cells of lymphoid organs was detected in 19 of 21 sick animals examined. Only 4 of 10 monkeys from high risk colony without clinical manifestations had virus-specific sequences in their cellular DNAs. As a rule, S(H)TLV-I-infected cells monoclonally proliferated both in lymphomatous and healthy baboons. The restriction patterns with EcoRI, HindIII, PstI, BamHI of S(H)TLV-I provirus were similar but not identical to those of prototype HTLV-I and STLV-I isolates.

Asunto(s)

Linfoma/veterinaria , Enfermedades de los Monos/microbiología , Recombinación Genética , Retrovirus de los Simios/genética , Virus Linfotrópico T Tipo 1 de los Simios/genética , Animales , ADN Viral/genética , Desoxirribonucleasa BamHI , Desoxirribonucleasa EcoRI , Desoxirribonucleasa HindIII , Virus Linfotrópico T Tipo 1 Humano , Linfoma/microbiología , Hibridación de Ácido Nucleico , Papio/microbiología