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[Effect of synthetic antifungal drugs on the adherence of Candida albicans to the mouth mucosa epithelium in vitro]. / Wplyw syntetycznych leków przeciwgrzybiczych na przyleganie grzybów Candida albicans in vitro do nablonka jamy ustnej.

Macura, A B; Dwernicka, B.

Med Dosw Mikrobiol ; 41(1): 67-70, 1989.

Artículo en Polaco | MEDLINE | ID: mdl-2668662

RESUMEN

Ten Candida albicans strains were tested for their adherence to buccal epithelial cells in vitro in the presence of synthetic antimycotic drugs as 5-fluorocytosine, clotrimazole and ketoconazole. The drugs when applied in therapeutic concentrations inhibited adherence stronger than when applied in subinhibitory concentrations although in both situations the inhibition was statistically significant in comparison to control experiments without these drugs (p less than 0.01). The highest inhibition of adherence was seen with 5-fluorocytosine and the weakest with clotrimazole. Out of imidazole derived drugs strong inhibition of adherence was achieved with ketoconazole.

Asunto(s)

Candida albicans/efectos de los fármacos , Clotrimazol/farmacología , Flucitosina/farmacología , Imidazoles/farmacología , Cetoconazol/farmacología , Mucosa Bucal/microbiología , Adhesividad , Candida albicans/patogenicidad , Epitelio/microbiología , Femenino , Humanos , Técnicas In Vitro

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