RESUMEN

Adrenocortical tumours (ACT), which include adenomas, carcinomas and adrenal hyperplasia, may be associated with genetic syndromes, such as Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, multiple endocrine neoplasia type 1, familial adenomatous polyposis and Carney complex. Genetic defects have been found to be responsible for the disease in most of these syndromes, allowing genetic counselling to affected patients and family members. Here, we summarize the clinical criteria of these hereditary syndromes and briefly describe the genetic alterations related to them. In addition, we discuss the involvement of various genetic defects in the development of sporadic adrenocortical tumours.

Asunto(s)

Neoplasias de la Corteza Suprarrenal/genética , Hiperplasia Suprarrenal Congénita/genética , Adenoma Corticosuprarrenal/genética , Síndrome de Beckwith-Wiedemann/genética , Complejo de Carney/genética , Humanos , Síndrome de Li-Fraumeni/genética , Modelos Biológicos , Neoplasia Endocrina Múltiple Tipo 1/genética , Síndromes Neoplásicos Hereditarios/genética