Asunto(s)
Enfermedades Pulmonares/fisiopatología , Resistencia Vascular , Adulto , Asma/fisiopatología , Presión Sanguínea , Enfermedad Crónica , Fondo de Ojo , Humanos , Hipotensión/etiología , Hipotensión/fisiopatología , Enfermedades Pulmonares/etiología , Persona de Mediana Edad , Neumonía/fisiopatología , Vasos Retinianos/fisiopatologíaRESUMEN
Blood coagulability was studied in patients with ischaemic heart disease and microthromboses in the microcirculation as seen when examining the vessels of the bulbar conjunctiva. Appearance of single microthrombi in the microcirculatory bed was not accompanied by change of blood coagulability as compared to such patients without microthrombi. With multiple microthrombi increase of haemocoagulation properties and of thrombocyte aggregation was noted, more marked with multiple microthrombi in the venules and capillaries. With further spread of the process to arterioles the hypercoagulation tendencies were retained with signs of utilization of coagulation factors, which can be interpreted as disseminated intravascular coagulation.
Asunto(s)
Conjuntiva/irrigación sanguínea , Enfermedad Coronaria/fisiopatología , Hemostasis , Trombosis/fisiopatología , Adulto , Pruebas de Coagulación Sanguínea , Enfermedad Crónica , Femenino , Humanos , Masculino , Microcirculación/fisiopatología , Persona de Mediana EdadAsunto(s)
Conjuntiva/irrigación sanguínea , Enfermedad Coronaria/fisiopatología , Músculos/irrigación sanguínea , Consumo de Oxígeno , Adulto , Velocidad del Flujo Sanguíneo , Enfermedad Crónica , Humanos , Masculino , Microcirculación/fisiopatología , Persona de Mediana Edad , Infarto del Miocardio/fisiopatología , Flujo Sanguíneo RegionalAsunto(s)
Conjuntiva/irrigación sanguínea , Enfermedad Coronaria/fisiopatología , Adulto , Enfermedad Crónica , Relación Dosis-Respuesta a Droga , Epinefrina , Femenino , Histamina , Humanos , Masculino , Microcirculación/efectos de los fármacos , Microcirculación/fisiopatología , Persona de Mediana Edad , Resistencia Física , Estrés Psicológico/fisiopatología , Sistema Vasomotor/efectos de los fármacosAsunto(s)
Enfermedad Coronaria/tratamiento farmacológico , Hemostasis/efectos de los fármacos , Microcirculación/efectos de los fármacos , Teofilina/análogos & derivados , Niacinato de Xantinol/uso terapéutico , Adulto , Anciano , Enfermedad Crónica , Enfermedad Coronaria/fisiopatología , Evaluación de Medicamentos , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Most of the 104 patients with ischaemic heart disease had distinct functional and structural microcirculation disorders. The slugging syndrome was revealed in 98% of the cases. In 56% of the patients microthrombus formation was noted in the microcirculatory bed, as well as a reduction of the perfusion capillary blood flow and an increase of the shunting flow, the half-resorption of sodium-131I from the skin and muscle depot being decreased. A clear relationship is noticed between the intravascular microcirculatory disorders, the functional state of the erythrocytes and platelets, the increased coagulation potential of the blood, the appearance of components that indicate the possibility of a diffuse intravascular blood coagulation (fibrinogen B, products of fibrinogen and fibrin decomposition), the changes in lipid metabolism. Stasis of the blood flow with distinct signs of the slugging syndrome, microthrombosis, activation of the kallikrein-kinin system and increasing shunting flow were revealed in patient with a severe course of the disease. Criteria for a quantitative assessment of the noted changes were developed.