RESUMEN

PURPOSE: To report a case of conjunctival-corneal intraepithelial neoplasia (CCIN) in an elderly African American patient treated with topical mitomycin C and the subsequent complication of limbal stem cell deficiency. DESIGN: Interventional case report. METHODS: A 92-year-old African American woman was diagnosed with CCIN in the right eye. Following incisional biopsy, the patient received five 1-week courses of 0.04% mitomycin C and was followed over a period of 10 months. RESULTS: The CCIN regressed completely following mitomycin C therapy. Three months later, the patient developed recurrent nonhealing epithelial defects in the right cornea. CONCLUSIONS: Conjunctival-corneal intraepithelial neoplasia may occur in the African American population. Although MMC is effective in eradicating CCIN, a limbal stem cell deficiency may complicate the treatment.

Asunto(s)

Carcinoma in Situ/tratamiento farmacológico , Neoplasias de la Conjuntiva/tratamiento farmacológico , Enfermedades de la Córnea/inducido químicamente , Enfermedades de la Córnea/tratamiento farmacológico , Epitelio Corneal/efectos de los fármacos , Mitomicina/efectos adversos , Células Madre/efectos de los fármacos , Administración Tópica , Anciano , Anciano de 80 o más Años , Antibióticos Antineoplásicos/efectos adversos , Carcinoma in Situ/patología , Neoplasias de la Conjuntiva/patología , Enfermedades de la Córnea/patología , Epitelio Corneal/patología , Neoplasias del Ojo/tratamiento farmacológico , Neoplasias del Ojo/patología , Femenino , Humanos , Limbo de la Córnea/efectos de los fármacos , Limbo de la Córnea/patología , Recurrencia , Células Madre/patología