RESUMEN

Studies in recent years suggest a role for inflammation, proinflammatory cytokines in particular, the development of microvascular complications of diabetes, including nephropathy. We investigated the expression of IL-6 in the biopsy tissue kidneys (in glomeruli and interstitium) in 24 elderly patients with type 2 diabetes complicated by diabetic nephropathy. The significant influence of intrarenal expression of IL-6 on the development of morphological (glomerular and tubulointerstitial) changes in renal tissue in patients with diabetic nephropathy is shown.

Asunto(s)

Diabetes Mellitus Tipo 2/patología , Nefropatías Diabéticas/patología , Interleucina-6/fisiología , Riñón/patología , Anciano , Diabetes Mellitus Tipo 2/inmunología , Diabetes Mellitus Tipo 2/metabolismo , Nefropatías Diabéticas/inmunología , Nefropatías Diabéticas/metabolismo , Endotelio Vascular/inmunología , Endotelio Vascular/metabolismo , Endotelio Vascular/patología , Femenino , Humanos , Interleucina-6/biosíntesis , Riñón/irrigación sanguínea , Riñón/inmunología , Riñón/metabolismo , Pruebas de Función Renal , Masculino , Microscopía Fluorescente