RESUMEN
Patients with system lupus erythematosus, rheumatic arthritis, chronic active hepatitis and gout were found to have considerable hyperuricemia and be decreased in aminoacides content, which are the predecessors of purine. Hyperactivity of xanthineoxidase and POL content were also revealed. The close correlation relation of purine indices of such patients has been observed. The obtained data allow applying methods of correction of immunity system and purine metabolism to these patients by introducing in a complex therapy inhibitors of xanthineoxidase.
Asunto(s)
Aminoácidos/sangre , Enfermedades Autoinmunes/metabolismo , Gota/metabolismo , Hiperuricemia/metabolismo , Purinas/metabolismo , Aminoácidos/metabolismo , Enfermedades Autoinmunes/sangre , Enfermedades Autoinmunes/complicaciones , Gota/sangre , Gota/complicaciones , Humanos , Hiperuricemia/sangre , Hiperuricemia/etiología , Peróxidos Lipídicos/sangre , Ácido Úrico/sangre , Xantina Oxidasa/sangreRESUMEN
The condition was studied of the immune and nervous system in 72 miners who took part in the elimination of the aftermaths of the Chernobyl accident and in 30 miners of the control group. Ascertained in the miners-liquidators was the presence of imbalance of T-cells of the immune system and disorder of the humoral immunity. The patients displayed changes in the blood content of sodium, increased concentrations of iron, zink, and lead, and diminished amounts of cuprum. In this group pathology of the vegetative nervous system, vascular and vestibular abnormalities were found with high frequency. The findings secured attest to the need for taking account of particular features of disordered immunity, abnormalities of metabolism and nervous regulation in instituting a complex therapy in miners-liquidators.