RESUMEN
Objectives: This study aimed to explore the correlation between the degree of hearing loss (HL) and the degrees of anxiety and depression in patients with tinnitus. Materials and Methods: This retrospective study involved the use of basic clinical data from 600 enrolled patients with tinnitus who visited the otolaryngology clinic in Affiliated Jinhua Hospital, Zhejiang University School of Medicine from April 2020 to June 2022. The tinnitus handicap inventory (THI) scale was used to assess the tinnitus status among the participants. The pure tone audiometry (PTA) test was used to conduct audiological assessments for all patients to determine their hearing condition. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess the levels of anxiety and depression among the participants, respectively. The correlation between the HL and anxiety/depression scores from the questionnaires was tested through Pearson correlation analysis. Results: Among the 600 enrolled patients with tinnitus, most patients had mild-to-moderate degree of tinnitus, accounting for 248 cases (41.3%) and 179 cases (29.8%), respectively. PTA results showed that a large proportion of patients with tinnitus were accompanied with HL (467 cases, 77.8%). Among them, patients with mild HL accounted for the largest proportion with a total of 241 cases (40.2%). Based on the results of SAS and SDS test, almost half of the patients had symptoms of anxiety and depression, accounting for 52.3% (314 cases) and 48.8% (293 cases), respectively. Similarly, patients with mild anxiety and depression occupy the largest proportion, accounting for 35.8% (215 cases) and 23% (138 cases), respectively. Pearson correlation analysis showed that the degree of HL was closely related to THI/SAS/SDS scores (P < 0.001). Conclusion: These findings indicate a strong positive correlation between the degree of HL and anxiety/depression scores in patients with tinnitus.
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Pérdida Auditiva , Acúfeno , Humanos , Depresión/epidemiología , Depresión/etiología , Acúfeno/complicaciones , Estudios Retrospectivos , Ansiedad/etiología , Encuestas y CuestionariosRESUMEN
OBJECTIVE: This study aimed to analyze the voice characteristics of patients with early vocal fold polyps and to investigate the effects of voice therapy on patients. METHODS: Voice therapy was conducted on 88 patients with early vocal fold polyps in an experimental group. Laryngostroboscopy, the voice handicap index (VHI), and the dysphonia severity index (DSI) were applied to evaluate the patients' voice quality before and after treatment. Thirty-one healthy volunteers also underwent evaluation of voice quality as a control group. The intergroup and intragroup differences in the results of laryngostroboscopy, VHI, and DSI were compared statistically. RESULTS: In the experimental group, 22 patients withdrew from the treatment for various reasons. After voice therapy, the cure rate was 30.3% (20/66). All the VHI values in the experimental group before treatment were statistically worse than the values in the control group. The P and T values of the VHI in the experimental group were still worse after treatment than the values in the control group, although the VHI did improve after treatment in the experimental group. The maximum phonation time (MPT), jitter, I-low, and DSI were statistically different between the control group and the experimental group both before and after treatment. Furthermore, the MPT, jitter, F0-high, I-low, and DSI improved after treatment in the experimental group. CONCLUSIONS: Patients with early vocal fold polyps have some degree of subjective and objective dysphonia. Voice therapy can improve the voice quality in these patients.
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Disfonía/terapia , Enfermedades de la Laringe/complicaciones , Fonación , Pólipos/complicaciones , Pliegues Vocales/fisiopatología , Calidad de la Voz , Entrenamiento de la Voz , Acústica , Adulto , Estudios de Casos y Controles , Evaluación de la Discapacidad , Disfonía/diagnóstico , Disfonía/etiología , Disfonía/fisiopatología , Femenino , Humanos , Enfermedades de la Laringe/diagnóstico , Enfermedades de la Laringe/fisiopatología , Laringoscopía , Masculino , Persona de Mediana Edad , Pólipos/diagnóstico , Pólipos/fisiopatología , Recuperación de la Función , Índice de Severidad de la Enfermedad , Medición de la Producción del Habla , Estroboscopía , Factores de Tiempo , Resultado del TratamientoRESUMEN
Several case-control studies indicated that XRCC3 genetic polymorphism (C722T) was associated with larynx cancer. The present study aimed to further evaluate the relation between the XRCC3 gene C722T polymorphism and larynx cancer. We selected five case-control studies related to XRCC3 gene C722T polymorphism and larynx cancer by searching PubMed, EMBase, Chinese CNKI, and Wanfang database. RevMan 5.0 software was used to perform the analysis. We directly utilized Q test and I (2) test to test the heterogeneity between each study. We utilized the fixed effects model to merge the odds ratio (OR) and 95 % confidence interval. There were 1,507 larynx cancer patients and 3,623 cancer-free control subjects included in the present study. By meta-analysis, we did not find any association of XRCC3 gene C722T polymorphism with larynx cancer [OR=1.54, 95 % CI (0.77-3.08); P=0.22]. The present study indicated that XRCC3 gene C722T polymorphism was not associated with larynx cancer.
Asunto(s)
Proteínas de Unión al ADN/genética , Predisposición Genética a la Enfermedad , Neoplasias Laríngeas/genética , Polimorfismo Genético , Estudios de Casos y Controles , Humanos , Sesgo de PublicaciónRESUMEN
OBJECTIVE: To explore the presence of bacterial biofilms (BF) in patients with CRS and the effect of BF on clinical symptoms and postoperative outcomes. METHODS: Seventy-two patients with chronic sinusitis were enrolled in this study. The control group included 15 patients with deviation of the nasal septum and 10 patients had a fracture of the nasal bone. Mucosa of the uncinate process or ethmoid near the ostium of the maxillary sinus was obtained during endoscopic sinus surgery. The specimens were subjected to scanning electron microscopy. Patients were followed for 1 year and observed by the Lund-Kennedy endoscopy, and the Haikou standard classification (ESS-1997). Statistical analysis was performed by t-test or chi-square test. RESULTS: Three patients were lost to follow-up. The scanning electron microscopy analysis showed bacterial biofilms in 49 of the 69 patients with chronic sinusitis. A marked destruction of the epithelium and cilia was observed in samples positive for bacterial biofilms. No bacterial biofilms were detected in the control group, and scanning electron microscopy showed normal epithelium and cilia in those specimens. There was no significant difference in gender, classification or duration of disease between the BF(-) and BF(+) groups. At six months and one year postoperative, the Lund-Kennedy endoscopy scores for CRS patients with BF (4.78 +/- 1.67; 4.55 +/- 1.61) were significantly higher than those without BF (3.65 +/- 1.39; 3.65 +/- 1.18) (t = -2.654, P < 0.01; t = -2.264, P < 0.05). Based on the Haikou standard classification, there was a significantly difference between patients with BF and those without BF (chi2 = 18.014, 22.063, P < 0.001, respectively). CONCLUSIONS: Different life stages of bacterial biofilms were demonstrated to be present in CRS. Gender, classification or duration of disease did not affect the presence of bacterial biofilms in patients with CRS. There is a correlation between bacterial biofilms and an unfavorable outcome in patients with CRS after ESS.
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Biopelículas , Mucosa Nasal/microbiología , Pólipos Nasales/microbiología , Rinitis/microbiología , Sinusitis/microbiología , Adulto , Estudios de Casos y Controles , Enfermedad Crónica , Femenino , Estudios de Seguimiento , Humanos , Masculino , Microscopía Electrónica de Rastreo , Persona de Mediana Edad , Adulto JovenRESUMEN
PURPOSE: The purpose of the study was to investigate the expression of bacterial biofilm (BF) for chronic rhinosinusitis (CRS) and to find out factors affecting BF expression and the influences on its prognosis. MATERIALS AND METHODS: All specimens were analyzed by a scanning electron microscope and bacterial cultivation from a panel of 93 patients with CRS, 20 with nasal septum deviation, and 17 with nasal bone fractures as the control group. Referring to the grade classification criteria from the sinusitis-specific questionnaire Sino-Nasal Outcome Test-20, patients were assessed preoperatively based on common clinical manifestations. Patients were followed up for condition improvement as assessed by visual analogue scale and nasal endoscopic examination. RESULTS: In the experimental group, among all the patients, 3 were lost (lost 3.2%). Bacterial biofilm was positive in 64 (71.1%) of 90 patients. Mucosal cilia were observed in varying degrees of injury. Bacterial culture was positive in 60 (66.7%) patients. In the control group, no BF was found and no bacterium was cultured. Bacterial biofilm expression was correlated with the bacterial culture. The BF(+) patients' visual analogue scale scores 6 months and 1 year postoperation were lower than the BF(-) patients' scores (P < .05). The BF(+) patients' Lund-Kennedy scores at 6 months and 1 year postoperation were higher than the BF(-) patients' scores (P < .05). CONCLUSIONS: Bacterial biofilm is involved in the pathogenesis of CRS and is associated with the bacterial culture. Bacterial biofilm has a certain impact on patients' prognosis.