RESUMEN
We prospectively studied 21 cases of attachment of the lingual frenulum treated with laser excision, and report the results of a questionnaire survey of patients in the immediate postoperative phase.
Asunto(s)
Terapia por Láser/métodos , Láseres de Gas/uso terapéutico , Frenillo Lingual/cirugía , Adolescente , Adulto , Niño , Preescolar , Edema/etiología , Estudios de Seguimiento , Humanos , Higiene Bucal , Dolor Postoperatorio/etiología , Satisfacción del Paciente , Complicaciones Posoperatorias , Hemorragia Posoperatoria/etiología , Estudios Prospectivos , Habla/fisiología , Lengua/fisiología , Adulto JovenRESUMEN
Dental implants have proved to be a useful adjunct in the rehabilitation of oral cancer patients. We describe the case of a 62-year-old woman who presented with a white patch in the oral cavity, diagnosed to be a squamous cell carcinoma. She underwent extensive surgery including microvascular reconstruction, followed by implant rehabilitation. Unfortunately, she suffered from multiple episodes of peri-implantitis and later on went on to develop oral squamous cell carcinoma around two of the dental implants. Here, we highlight the importance of regular follow-up and maintaining a high index of suspicion in high-risk patients.
Asunto(s)
Carcinoma de Células Escamosas/diagnóstico , Implantes Dentales , Neoplasias de la Boca/diagnóstico , Periodontitis/etiología , Carcinoma de Células Escamosas/rehabilitación , Carcinoma de Células Escamosas/cirugía , Resultado Fatal , Femenino , Humanos , Persona de Mediana Edad , Neoplasias de la Boca/rehabilitación , Neoplasias de la Boca/cirugía , Recurrencia Local de Neoplasia , Periodontitis/diagnósticoAsunto(s)
Nariz , Úlcera Cutánea/cirugía , Enfermedades del Nervio Trigémino/cirugía , Anciano , Femenino , Humanos , SíndromeRESUMEN
PURPOSE: There has been much interest in the role that the signaling molecule nitric oxide (NO) plays in cancer. NO has both tumor-promoting and tumor-inhibiting effects that are dependent on its local tissue concentration. In animal studies, the administration of exogenous NO has reduced both tumor growth and dissemination, and in vitro NO administration causes death of oral cancer cell lines. We evaluated the oral administration of the NO donor drug isosorbide mononitrate (ISMO) on cellular proliferation in patients with oral squamous cell carcinoma. MATERIALS AND METHODS: A prospective randomized double-blind study was performed on 31 patients with biopsy-confirmed oral squamous cell carcinoma. Following incisional biopsy, patients were randomized to receive either ISMO (at a dose of 20 mg twice a day) or placebo tablets for 2 weeks before definitive resection. Cellular proliferation was compared between biopsy and resection specimens, using the immunohistochemical marker Ki-67. RESULTS: No statistical difference was found between Ki-67 indices in initial biopsy and resection specimens after ISMO (P =.23) or placebo (P =.5) administration. There were no obvious clinical changes seen in the tumor during the clinical trial as a result of ISMO administration. CONCLUSION: Although high concentrations of NO are cytotoxic, it is unlikely that administration of NO at an increased dose would be useful in the management of oral cancer because this would result in unacceptable systemic side effects. The possible manipulation of NO in oral cancer is discussed.