RESUMEN
Retrospective analysis of heparin efficacy (25,000 IU daily for 3 weeks) was carried out in 59 patients with different morphological and clinical forms of glomerulonephritis. The treatment proved to be effective in 32.2% of patients. Among unsuccessfully treated patients those with severe clinical and morphological forms prevailed. Indication for administration of heparin were specified. Disappearance of fibrin/fibrinogen degradation products from urine or fall in their level by 50% or more a week after the start of heparin were considered prognostically favourable. Graphical turbidimetry is recognized to be the best method of haemostasis monitoring during heparin therapy.
Asunto(s)
Glomerulonefritis/tratamiento farmacológico , Heparina/uso terapéutico , Enfermedad Aguda , Adolescente , Adulto , Enfermedad Crónica , Diuresis/efectos de los fármacos , Evaluación de Medicamentos , Femenino , Glomerulonefritis/sangre , Glomerulonefritis/epidemiología , Glomerulonefritis/fisiopatología , Hemostasis/efectos de los fármacos , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Estudios RetrospectivosRESUMEN
Results are compared of glucocorticoid treatment of proliferative, mesangioproliferative and membraneous types of glomerulonephritis with initial levels of T- and B-lymphocytes. Five types of immunodeficiency states were distinguished different frequency of the latter in various types of glomeruli involvement. It was found that glucocorticoid therapy of nephritis is most efficient in cases when the initial number of T-lymphocytes was within normal limits while the content of B-lymphocytes was increased.
Asunto(s)
Glomerulonefritis/tratamiento farmacológico , Glucocorticoides/uso terapéutico , Síndromes de Inmunodeficiencia/tratamiento farmacológico , Síndrome Nefrótico/tratamiento farmacológico , Linfocitos B/efectos de los fármacos , Linfocitos B/inmunología , Evaluación de Medicamentos , Glomerulonefritis/inmunología , Humanos , Inmunidad Celular/efectos de los fármacos , Síndromes de Inmunodeficiencia/inmunología , Síndrome Nefrótico/inmunología , Inducción de Remisión , Formación de Roseta , Linfocitos T/efectos de los fármacos , Linfocitos T/inmunologíaRESUMEN
Immediate results are analyzed of the treatment of 57 glomerulonephritis patients with the urinary syndrome using indomethacin. The treatment proved effective in 65% of patients. It was established that indomethacin had no immunotropic effects in urinary syndrome. Absence of arterial hypertension is not a prognosis-positive factor for treatment of the urinary syndrome with indomethacin.
Asunto(s)
Glomerulonefritis/tratamiento farmacológico , Indometacina/uso terapéutico , Adolescente , Adulto , Evaluación de Medicamentos , Femenino , Glomerulonefritis/complicaciones , Humanos , Masculino , SíndromeRESUMEN
An analysis is presented of direct results of monotherapy with cyclophosphamide of 70 patients suffering of acute and chronic glomerulonephritis. The treatment proved effective in 10% of patients. It was established that the initially reduced levels of immunoglobulins G and A in the blood serum of patients with glomerulonephritis are a prognosis-positive factor for the use of cyclophosphamide.